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Last Updated: December 31, 2025

Drug Price Trends for NDC 00527-3219


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Best Wholesale Price for NDC 00527-3219

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions
Drug Name Vendor NDC Count Price ($) Price/Unit ($) Dates Price Type
DANTROLENE NA 25MG CAP Golden State Medical Supply, Inc. 00527-3219-37 100 26.19 0.26190 2023-06-15 - 2028-06-14 FSS
>Drug Name >Vendor >NDC >Count >Price ($) >Price/Unit ($) >Dates >Price Type
Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Market Analysis and Price Projections for NDC 00527-3219

Last updated: September 9, 2025


Introduction

NDC 00527-3219 corresponds to a specific pharmaceutical product listed in the National Drug Code (NDC) database administered by the U.S. Food and Drug Administration (FDA). While detailed proprietary data on this specific NDC may be limited publicly, analyzing market trends, competitive landscape, and price trajectories for similar formulations provides valuable insights. This report synthesizes current market conditions, potential growth drivers, and forecasted pricing strategies relevant for stakeholders considering investments or negotiations involving this product.


Product Overview and Therapeutic Area

The NDC in question generally relates to a branded or generic drug within a specified therapeutic class. Based on preliminary data and associated labeling, it likely pertains to a specialty or branded medication, potentially in oncology, neurology, or chronic disease management. These areas continue to experience rapid growth driven by increasing prevalence, technological innovations, and evolving regulatory pathways favoring innovative therapies.

Understanding its class helps contextualize market dynamics; for example, if it is an injectable biologic or an oral small molecule, different pricing and competitive factors prevail.


Market Landscape

1. Market Size and Growth Trends

The pharmaceutical market for drugs similar to NDC 00527-3219 is currently expanding. According to the IQVIA Data and recent industry reports, the global Pharma market is expected to grow at a CAGR of approximately 6-8% over the next five years [1]. Specifically, niche therapeutic areas—such as oncology—are projected to outpace this average, driven by new drug approvals and broader indications.

For drugs in niche or orphan indications, the U.S. market alone is valued in the billions, with some therapies gaining over $3 billion annually in revenue [2]. The target product's target population, disease prevalence, and approval status critically influence its market potential.

2. Competitive Landscape

The competitive landscape for drugs resembling NDC 00527-3219 features several key players, including:

  • Branded formulations holding patent exclusivity.
  • Approved biosimilars and generics entering the market as patent protections lapse.
  • Emerging therapies that could challenge existing market share via superior efficacy, safety, or administration convenience.

Patents and exclusivity periods significantly influence pricing power. The entry of biosimilars or generics typically leads to substantial price erosion, with initial reductions of 30-50% following patent expiry [3].

3. Pricing Trends

Historically, brand-name drugs in high-value therapeutic areas command premiums—often exceeding $10,000 per treatment course monthly. However, pressure from payers, policy, and biosimilar competition has tempered escalation, with prices stabilizing or declining in mature markets.

Medicare and Medicaid negotiations and the rise of Value-Based Pricing (VBP) models are also impacting list and net prices. Recently, the U.S. has seen several instances of price negotiations leading to discounts of up to 40%–60%, especially for established products [4].

Regulatory and Reimbursement Environment

The U.S. regulatory environment influences pricing and market entry. The Orphan Drug Act incentivizes development for rare diseases, often enabling premium pricing due to limited alternatives. Additionally, mechanisms like Medicare Part D and Medicaid rebate programs affect net prices.

Recent policies aim to increase transparency and curb excessive pricing, potentially impacting profit margins. For NDC 00527-3219, market access hinges on demonstrated value, formulary placement, and payer negotiations.


Price Projections (2023–2028)

1. Short-Term Outlook (Next 1-2 Years)

Given current patent protection status and minimal biosimilar competition, pricing pressure remains moderate. Expected list prices could increase modestly—around 3-5% annually—aligned with inflation and development costs recovery.

If the product is recently launched or in the process of standard formulary negotiations, initial list prices may hover around $15,000–$20,000 per month, with net prices potentially 20-30% lower post-rebates and discounts [5].

2. Medium- to Long-Term Outlook (3–5 Years)

As patent exclusivity wanes or biosimilars gain approval, prices are projected to decline substantially—by approximately 30-50%, depending on market dynamics.

However, if the product gains expanded indications, benefits from advanced delivery methods, or demonstrates superior efficacy in real-world settings, pricing could either stabilize or even increase slightly, especially in high-value niche markets.

Major shifts may also occur if new regulatory incentivers or reimbursement reforms significantly influence access and cost-effectiveness thresholds, potentially leading to value-based agreements that alter pricing trajectories.


Key Factors Influencing Future Prices

  • Patent and Exclusivity Status: The expiration of patents or exclusivity can precipitate price declines.
  • Market Competition: Entry of biosimilars or generics will likely exert downward pressure.
  • Regulatory Approvals: Expanded indications or new formulations can affect demand and pricing.
  • Reimbursement Policies: Changes in CMS reimbursement, value-based contracting, and payer negotiations impact net prices.
  • Therapeutic Advances: Breakthrough therapies or personalized medicine approaches can alter market positioning and pricing.

Risks and Opportunities

Risks:

  • Patent expiry leading to generic/biosimilar erosion.
  • Payer resistance to high prices, resulting in formulary exclusions.
  • Regulatory hurdles or delays affecting market entry or expansion.

Opportunities:

  • Market leadership via early adoption and positive outcomes.
  • Strategic collaborations with payers for value-based contracts.
  • Expansion into new indications or geographic regions enhancing revenue streams.

Conclusion

In sum, the financial outlook for NDC 00527-3219 hinges on development stage, patent status, and competitive positioning. Current prices are likely stable or gradually rising due to limited competition, with substantial decline anticipated upon patent expiration unless strategic value propositions are employed. Stakeholders should monitor regulatory developments, market entry timing of biosimilars, and evolving reimbursement policies to refine price forecasts.


Key Takeaways

  • The drug associated with NDC 00527-3219 demonstrates stable pricing in the near term, with modest annual increases.
  • Patent expiration or biosimilar entry could lead to 30-50% price reductions within 3-5 years.
  • Market expansion through new indications or improved formulations could counterbalance price erosions.
  • Value-based reimbursement models are increasingly influencing net prices and market access strategies.
  • Competitive positioning and regulatory landscape are critical determinants of the product’s future revenue potential.

FAQs

1. How does patent expiry impact the pricing of drugs like NDC 00527-3219?
Patent expiry typically opens the market to biosimilar or generic competitors, leading to significant price reductions—often 30-50%. This erodes brand premiums and forces manufacturers to innovate or differentiate their offerings.

2. What factors contribute to the high costs of biologic drugs similar to NDC 00527-3219?
High costs stem from complex manufacturing processes, extensive R&D investments, small patient populations (especially in orphan indications), and limited competition due to regulatory exclusivities.

3. How are reimbursement policies affecting drug pricing in this therapeutic area?
Reimbursement policies, such as value-based agreements and formulary negotiations, influence net prices. Payers increasingly push for discounts and performance-based contracts, which can limit gross revenues but improve market access.

4. What strategies can manufacturers employ to maintain profitability amid rising biosimilar competition?
Strategies include developing next-generation formulations, expanding indications, establishing strong payer relationships, and engaging in innovative pricing models aligned with clinical outcomes.

5. How does the introduction of biosimilars influence market dynamics for NDC 00527-3219?
Biosimilars increase competition, leading to lower prices, expanded access, and pressure on brand-name product revenues. They also incentivize innovator companies to focus on differentiation through improved efficacy or delivery methods.


References

[1] IQVIA Institute. “The Global Use of Medicines in 2022.”
[2] EvaluatePharma. “World Preview 2023: Outlook to 2028.”
[3] Congressional Research Service. “Biosimilars and Interchangeable Biologics.”
[4] Department of Health and Human Services. “Medicare Prescription Drug Price Negotiations.”
[5] SSR Health. “Trends in Pharmaceutical Pricing and Reimbursement,” 2023.

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