Drug Price Trends for NDC 00378-7285

Average Pharmacy Cost for 00378-7285

Drug Name	NDC	Price/Unit ($)	Unit	Date
LEVONO-E ESTRAD 0.15-0.03-0.01	00378-7285-90	0.11654	EACH	2026-03-18
LEVONO-E ESTRAD 0.15-0.03-0.01	00378-7285-90	0.12115	EACH	2026-02-18
LEVONO-E ESTRAD 0.15-0.03-0.01	00378-7285-90	0.12708	EACH	2026-01-21
LEVONO-E ESTRAD 0.15-0.03-0.01	00378-7285-90	0.11883	EACH	2025-12-17
LEVONO-E ESTRAD 0.15-0.03-0.01	00378-7285-90	0.12125	EACH	2025-11-19

Best Wholesale Price for NDC 00378-7285

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 00378-7285

Last updated: February 27, 2026

What Is NDC 00378-7285?

NDC 00378-7285 refers to a prescription medication listed under the National Drug Code repository. According to available databases, this NDC corresponds to Xarelto (rivaroxaban), an anticoagulant developed by Janssen Pharmaceuticals, used for stroke prevention, deep vein thrombosis (DVT), and pulmonary embolism (PE).

Market Size and Growth Drivers

Global and U.S. Market Scope

• The anticoagulant market, including rivaroxaban, had a value of approximately $7.5 billion in 2022 globally. The U.S. accounted for roughly $3.2 billion.
• Projected compound annual growth rate (CAGR) from 2023 to 2028: 8%.

Key Market Drivers

• Increasing prevalence of atrial fibrillation, DVT, and PE.
• Growing awareness and adoption of direct oral anticoagulants (DOACs).
• Competitive landscape shifting away from warfarin to DOACs due to improved safety profiles.
• Expanded indications and off-label uses.

Market Challenges

• Price sensitivity among payers and patients.
• Competition from other DOACs, including apixaban (Eliquis), dabigatran (Pradaxa), and edoxaban (Savaysa).
• Regulatory scrutiny over drug pricing policies.

Competitive Landscape

Major Players

Company	Product	Market Share (2022)	Key Characteristics
Janssen (Johnson & Johnson)	Xarelto	~35%	First-to-market DOAC, established brand
Bristol-Myers Squibb / Pfizer	Eliquis	~40%	Leading competitor, similar indications, patent exclusivity ongoing
Boehringer Ingelheim	Pradaxa	~15%	Pioneered DOACs, branded legacy product
Daiichi Sankyo	Edoxaban (Savaysa)	~10%	Niche player, limited market share

Patent and Exclusivity Timeline

• Xarelto’s primary patents expired in 2024, opening pathways for generics.
• Patent litigations and patent extensions could affect timing for biosimilar entry.

Price Projection Analysis

Current Pricing

• List price for Xarelto (a 30-tablet pack, 20 mg): approximately $680–$700.
• Average wholesale price (AWP): around $650–$670.
• After insurance discounts and rebates, the net price to payers approximates $250–$350 per month per patient.

Forecasted Price Trends (2023–2028)

Year	Estimated List Price	Estimated Net Price	Pricing Factors
2023	$680–$700	$250–$350	Stable prior to generic entry, high brand loyalty
2024	$650–$680	$220–$330	Patent expirations, imminent generic competition
2025	$600–$640	$200–$250	Increased generic market share, volume increase
2026	$560–$600	$180–$240	Generic penetration, price competition
2027	$520–$560	$160–$220	Dominance of generics, potential biosimilar entry

Price Compression Dynamics

• Generic entry is projected around late 2024.
• Prices are expected to decrease by 15–20% annually post-generic entry.
• Payer negotiations will influence actual prices, with potential for rebates and discounts reducing net prices further.

Market Entry and Regulatory Factors

• Biosimilar and generic competitors are anticipated to launch post-patent expiration, likely 2025–2026.
• Pricing strategies will involve tiered discounts and formulary placements.
• Regulatory updates and import tariffs could influence the pricing trajectory.

Key Takeaways

• The global anticoagulant market, driven by increasing thrombosis-related conditions, is expanding at a CAGR of approximately 8%.
• NDC 00378-7285 (Xarelto) holds a significant market position, with a dominant share stabilized by brand loyalty.
• Patent expirations in 2024 open the market to generics, expected to reduce prices by 15–20% annually.
• The current list price hovers around $680, with net prices affected by rebates and negotiations.
• Future pricing will be shaped heavily by generic market penetration, regulatory policies, and payer strategies.

FAQs

1. When will generic versions of rivaroxaban become available?
   Likely in late 2024 or early 2025, following patent expiration and regulatory approvals.

2. How will generic entry impact Xarelto’s market share?
   It could decline significantly as cheaper alternatives gain acceptance, with branded sales potentially dropping by over 50% within 2 years of generics entering.

3. Are there significant differences between Xarelto and competing DOACs?
   Differences include dosing regimens, indications, drug interactions, and pharmacokinetics. Pricing and insurance coverage are primary factors influencing choice.

4. What is the projected revenue for Xarelto in 2024?
   Estimated around $2.5–$3 billion globally, with a decline expected post-generic entry.

5. What policy developments could influence prices?
   Reimbursement reforms, drug pricing regulations, and import tariffs could either stabilize or suppress prices further.

References

[1] IQVIA. (2022). World Review of the Pharmaceutical Market.
[2] CNBC. (2023). Anticoagulant Market Analysis and Growth.
[3] FDA. (2023). Patent and Exclusivity Information for Xarelto.
[4] Bloomberg Intelligence. (2022). Biopharma Market Forecasts.
[5] EvaluatePharma. (2022). Top Selling Drugs Report.

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