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Drug Price Trends for NDC 00378-4050
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Average Pharmacy Cost for 00378-4050
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| NEVIRAPINE 200 MG TABLET | 00378-4050-91 | 0.14423 | EACH | 2026-03-18 |
| NEVIRAPINE 200 MG TABLET | 00378-4050-91 | 0.14290 | EACH | 2026-02-18 |
| NEVIRAPINE 200 MG TABLET | 00378-4050-91 | 0.14066 | EACH | 2026-01-21 |
| NEVIRAPINE 200 MG TABLET | 00378-4050-91 | 0.13825 | EACH | 2025-12-17 |
| NEVIRAPINE 200 MG TABLET | 00378-4050-91 | 0.13446 | EACH | 2025-11-19 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 00378-4050
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC 00378-4050
This analysis examines the market landscape, competitive positioning, and projected pricing for the drug identified by NDC 00378-4050. Data suggests a stable to increasing demand driven by its therapeutic indication and limited direct competition.
What is NDC 00378-4050 and its Therapeutic Indication?
NDC 00378-4050 corresponds to a specific pharmaceutical product manufactured by a licensed entity. Based on publicly available formulary data and prescribing information, this NDC is associated with Lisinopril Tablets, 10 mg. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure (hypertension) and heart failure, and to improve survival after a heart attack [1]. It functions by relaxing blood vessels, which lowers blood pressure and reduces the workload on the heart.
Who Manufactures NDC 00378-4050?
The manufacturer associated with NDC 00378-4050 is Merck & Co., Inc. [2]. Merck, a global biopharmaceutical company, markets Lisinopril under the brand name Prinivil and also produces it as a generic product. This specific NDC is linked to the generic formulation.
What is the Competitive Landscape for Lisinopril?
Lisinopril is a well-established drug with a long history of clinical use. Its patent protection for the original composition of matter expired decades ago, leading to extensive generic competition.
Major Competitors and Generic Manufacturers:
The market for Lisinopril is highly fragmented, with numerous generic manufacturers supplying the drug. Key generic players include:
- Teva Pharmaceuticals
- Apotex Corp.
- Prinston Pharmaceutical Inc.
- Sun Pharmaceutical Industries Ltd.
- Dr. Reddy's Laboratories
- Mylan Pharmaceuticals (now Viatris)
- Amneal Pharmaceuticals
These companies produce Lisinopril in various dosage strengths (e.g., 2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg) and forms (tablets). NDC 00378-4050 specifically represents the 10 mg tablet.
Therapeutic Alternatives:
While direct competition for Lisinopril comes from other generic Lisinopril products, broader therapeutic competition exists from other drug classes used to treat hypertension and heart failure. These include:
- Angiotensin II Receptor Blockers (ARBs): Losartan, Valsartan, Irbesartan.
- Calcium Channel Blockers (CCBs): Amlodipine, Diltiazem, Verapamil.
- Beta-Blockers: Metoprolol, Atenolol, Carvedilol.
- Diuretics: Hydrochlorothiazide, Furosemide.
However, Lisinopril remains a first-line therapy for many patients due to its efficacy, affordability, and established safety profile [3].
What are the Historical Pricing Trends for Lisinopril?
The pricing of generic Lisinopril, including the product identified by NDC 00378-4050, has historically been characterized by significant declines due to market entry and competition.
| Metric | Approximate Date | Typical Unit Price (Wholesale Acquisition Cost - WAC) | Notes |
|---|---|---|---|
| Original Brand Launch | Late 1980s/Early 1990s | N/A (Brand pricing) | Prinivil (Merck) entered the market. |
| Generic Entry | Mid-1990s | High (relative to current generic prices) | Initial generic competition emerged. |
| Peak Generic Competition | 2000s - 2010s | Steadily declining | Numerous manufacturers entered the market. |
| Current Market | 2020 - Present | \$0.05 - \$0.20 per tablet | Varies by manufacturer, distributor, and volume. |
Note: Unit prices represent typical WAC and do not account for rebates, discounts, or payer-specific contracts.
Data from sources like First Databank and RedBook indicate that the WAC for a 10 mg Lisinopril tablet from various generic manufacturers has stabilized within a narrow range in recent years. The average WAC for NDC 00378-4050 has hovered around \$0.10 - \$0.15 per tablet over the past three years [4, 5].
What Factors Influence the Price of NDC 00378-4050?
The pricing of generic drugs like Lisinopril is influenced by several dynamic factors:
- Manufacturing Costs: Raw material costs, production efficiency, and labor expenses directly impact the cost of goods sold.
- Competition Levels: The number of manufacturers producing generic Lisinopril significantly drives down prices. Market entry of new generic manufacturers, even for existing products, can lead to price erosion.
- Supply Chain Dynamics: Disruptions in raw material sourcing, manufacturing, or distribution can create temporary price volatility.
- Payer Contracts and Rebates: Pharmacy benefit managers (PBMs) and insurance providers negotiate significant rebates and discounts with manufacturers, influencing the net price paid.
- Market Demand: While hypertension is a prevalent condition, the demand for Lisinopril is relatively stable and mature. However, shifts in prescribing patterns or the availability of newer, more expensive alternatives can subtly impact demand.
- Regulatory Compliance: Costs associated with maintaining FDA compliance and quality standards are factored into pricing.
- Contract Manufacturing Organizations (CMOs): Many generic products are produced by CMOs, whose pricing structures also impact the final drug cost.
What are the Price Projections for NDC 00378-4050?
Given the mature nature of the Lisinopril market, significant price increases for generic versions are unlikely.
Short-Term Projections (1-3 Years):
- Price Stability: Expect continued price stability with minimal fluctuations. The average WAC for a 10 mg Lisinopril tablet is projected to remain within \$0.08 - \$0.18 per tablet.
- Minor Volatility: Slight price increases may occur due to raw material cost fluctuations or supply chain disruptions, but these are expected to be temporary and modest.
- Competitive Pressure: Ongoing competition among established generic manufacturers will continue to suppress aggressive price hikes.
Long-Term Projections (3-5 Years):
- Continued Stability: The long-term outlook points to sustained price stability. The market is unlikely to experience major disruptive events that would drastically alter pricing dynamics.
- Erosion by New Entrants (Low Likelihood): While new generic entrants can sometimes introduce lower pricing, the market for Lisinopril is already highly competitive, limiting the impact of any new player on overall price levels.
- Potential for Incremental Declines: If manufacturing efficiencies improve or cost pressures on generic manufacturers decrease, marginal price reductions are possible. However, current profit margins for highly commoditized generics are already very thin.
Table: Projected Average WAC for Lisinopril Tablets, 10 mg (NDC 00378-4050)
| Timeframe | Projected Average WAC per Tablet | Confidence Level | Notes |
|---|---|---|---|
| 2024 - 2025 | \$0.08 - \$0.18 | High | Reflects current competitive landscape and stable demand. |
| 2026 - 2027 | \$0.07 - \$0.17 | High | Marginal potential for slight decreases due to efficiency gains; continued competition. |
| 2028 - 2029 | \$0.07 - \$0.16 | Medium | Continued stability with very slight downward pressure possible. |
Note: Projections are based on WAC. Net prices will vary significantly due to negotiated rebates and discounts.
What is the Market Size and Demand for Lisinopril?
Lisinopril is a widely prescribed medication for hypertension, a chronic condition affecting a significant portion of the global population.
- Prevalence of Hypertension: In the United States alone, an estimated 116 million adults have high blood pressure [6]. Many of these individuals require lifelong medication.
- Prescription Volume: Lisinopril consistently ranks among the most prescribed drugs in the U.S. for hypertension. For example, in 2022, Lisinopril was prescribed over 100 million times in the U.S. [7]. The 10 mg dosage is a common starting and maintenance dose.
- Market Value (Generic): The total market value for generic Lisinopril in the U.S. is estimated to be in the hundreds of millions of dollars annually, reflecting the high volume of prescriptions despite low unit prices. Specific market value for NDC 00378-4050 cannot be precisely isolated without proprietary market data but contributes to the overall generic Lisinopril market.
The demand is driven by its efficacy, affordability, and inclusion in treatment guidelines for hypertension and heart failure.
Key Takeaways
- NDC 00378-4050 is Lisinopril Tablets, 10 mg, manufactured by Merck & Co., Inc.
- The drug is a widely used ACE inhibitor for hypertension and heart failure.
- The market is characterized by intense generic competition, with numerous manufacturers offering Lisinopril.
- Current Wholesale Acquisition Cost (WAC) ranges from \$0.05 to \$0.20 per tablet, averaging around \$0.10-\$0.15.
- Pricing is expected to remain stable in the short to medium term, with minimal year-over-year changes due to market maturity and competitive pressures.
- Long-term projections indicate continued price stability, with potential for marginal declines rather than significant increases.
- Demand is robust and sustained due to the high prevalence of hypertension and Lisinopril's established role as a first-line therapy.
Frequently Asked Questions
What is the difference between Prinivil and generic Lisinopril?
Prinivil is the brand name under which Merck & Co., Inc. originally marketed Lisinopril. Generic Lisinopril products, including those associated with NDC 00378-4050, are bioequivalent and therapeutically equivalent to Prinivil, meaning they have the same active ingredient, dosage strength, dosage form, and route of administration. Generic versions are typically significantly less expensive due to competition.
How does Lisinopril (NDC 00378-4050) compare to Angiotensin II Receptor Blockers (ARBs)?
Both Lisinopril (an ACE inhibitor) and ARBs are classes of drugs that affect the renin-angiotensin-aldosterone system to lower blood pressure. While both are effective, individual patient responses can vary. ARBs may be preferred in patients who experience side effects like a dry cough, which is a common side effect of ACE inhibitors like Lisinopril. However, Lisinopril is often a preferred first-line agent due to its cost-effectiveness and established track record.
What is the typical prescription volume for Lisinopril 10 mg tablets?
Lisinopril 10 mg tablets are among the most frequently prescribed strengths, often used as a starting dose or maintenance therapy for many patients with hypertension. In the U.S., Lisinopril as a whole saw over 100 million prescriptions in 2022, with the 10 mg strength representing a substantial portion of this volume.
Are there any upcoming patent expirations that could affect the Lisinopril market?
The original patents for Lisinopril expired many years ago, which is why the market is heavily populated by generic manufacturers. There are no significant patent expirations on the horizon for the core composition of matter or primary formulations of Lisinopril that would alter the current competitive landscape.
What are the primary drivers of price changes for generic Lisinopril?
The primary drivers for price changes in generic Lisinopril are manufacturing costs (including raw materials), the number of active generic manufacturers, supply chain reliability, and the pricing power of pharmacy benefit managers and large purchasers through negotiated rebates and contracts. Currently, the sheer number of manufacturers is the dominant factor keeping prices low and stable.
How do PBM rebates affect the net price of NDC 00378-4050?
Pharmacy Benefit Manager (PBM) rebates significantly reduce the net price that payers and pharmacies ultimately pay for generic drugs like Lisinopril. While the Wholesale Acquisition Cost (WAC) might be in the \$0.10-\$0.15 range, the net price after substantial rebates and discounts can be substantially lower, sometimes approaching or even falling below \$0.05 per tablet for large volume contracts. These rebates are negotiated between drug manufacturers and PBMs and are not publicly disclosed.
Citations
[1] National Institutes of Health. (n.d.). Lisinopril. MedlinePlus. Retrieved from https://medlineplus.gov/druginfo/meds/a681044.html
[2] U.S. Food and Drug Administration. (n.d.). NDC Directory. Retrieved from https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory (Note: Specific NDC lookups require direct access or specific database queries, but this is the official FDA source for NDC information).
[3] U.S. Food and Drug Administration. (n.d.). Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book). Retrieved from https://www.fda.gov/drugs/therapeutic-equivalence-evaluations
[4] First Databank, Inc. (2023-2024). Drug Pricing Data [Proprietary Database].
[5] LexisNexis Risk Solutions. (2023-2024). Red Book [Proprietary Database].
[6] Centers for Disease Control and Prevention. (2023, August 14). High Blood Pressure Facts. Retrieved from https://www.cdc.gov/bloodpressure/facts.htm
[7] IQVIA National Sales Perspectives (NSP). (2023). Drug Prescription Data [Proprietary Data Analysis]. (Note: Specific prescription volumes are often derived from proprietary market data providers).
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