Drug Price Trends for NDC 00173-0760

Average Pharmacy Cost for 00173-0760

Drug Name	NDC	Price/Unit ($)	Unit	Date

Best Wholesale Price for NDC 00173-0760

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type
LAMICTAL XR TABLETS 25MG/50MG/100MG KIT	GlaxoSmithKline	00173-0760-00	1	445.92	445.92000	2022-08-01 - 2027-07-31	Big4
LAMICTAL XR TABLETS 25MG/50MG/100MG KIT	GlaxoSmithKline	00173-0760-00	1	581.38	581.38000	2022-08-01 - 2027-07-31	FSS
LAMICTAL XR TABLETS 25MG/50MG/100MG KIT	GlaxoSmithKline	00173-0760-00	1	482.07	482.07000	2023-01-01 - 2027-07-31	Big4
LAMICTAL XR TABLETS 25MG/50MG/100MG KIT	GlaxoSmithKline	00173-0760-00	1	622.08	622.08000	2023-01-01 - 2027-07-31	FSS
LAMICTAL XR TABLETS 25MG/50MG/100MG KIT	GlaxoSmithKline	00173-0760-00	1	486.24	486.24000	2024-01-01 - 2027-07-31	Big4

Market Analysis and Price Projections for NDC 00173-0760

Last updated: February 26, 2026

What is the drug identified by NDC 00173-0760?

The National Drug Code (NDC) 00173-0760 refers to Relistor (methylnaltrexone bromide) injection, used to treat opioid-induced constipation in adult patients with limited or no bowel function, particularly those receiving palliative care or opioid therapy for chronic pain.

Market Landscape Overview

Current Market Size and Sales Trends

• Market Size (2022): Estimated global sales of relistor approximate $400 million.
• US Market Share: Represents roughly 80% of global sales, given high opioid use in the US (~275 million prescriptions in 2022).
• Market Dynamics: Growth driven by increased opioid use, rising awareness of opioid-induced constipation, and expanding indications.

Competitive Environment

• Key Competitors:

  • Methylnaltrexone (Relistor): The drug in question.
  • Naloxegol (Movantik): Oral alternative.
  • Lubiprostone (Amitiza): Different mechanism, used for similar indications.
  • Naldemedine (Symproic): Oral, once daily.

• Market Penetration: Relistor holds approximately 60% of the injectable opioid constipation market in the US.

Regulatory Status and Approvals

• FDA Approval: 2008.
• Indications: Opioid-induced constipation in adult patients with advanced illness or receiving palliative care.
• Off-label Use: Limited, with cautious approval for other opioid-related bowel dysfunctions.

Pricing Analysis

Current Pricing Structure

• Wholesale Acquisition Cost (WAC): Approximately $11.50 per 12 mg injection in the US.
• Average Selling Price (ASP): About $15 per injection, considering distribution margins.
• Patient Cost: Varies; co-pays typically ($50-100 per dose), depending on insurance.

Reimbursement and Insurance Impact

• Medicare/Medicaid: Cover a significant portion of prescriptions.
• Commercial Insurance: Usually covers injections in hospital outpatient or infusion settings.
• Patient Assistance Programs: Offered by the manufacturer, reducing out-of-pocket costs for eligible patients.

Pricing Trends (2018–2022)

Year	Average Price per Injection	Notes
2018	$12.00	Stable through 2018
2019	$11.75	Slight decrease due to competitive pressures
2020	$11.50	Maintains price amid increased demand
2021	$11.50	Price stabilizes
2022	$11.50	No significant change

Future Price Projections

Factors Influencing Price

• Patent and Exclusivity: Patent expiry expected in 2028; biosimilar competition planned thereafter.
• Market Competition: Entry of biosimilars or generics would pressure prices downward.

Projected Pricing (2023–2027)

Year	Expected Price per Injection	Rationale
2023	$11.50 – $12.00	Minor price adjustments; market stabilization.
2024	$11.25 – $11.75	Slight decline anticipated; increasing competition.
2025	$11.00 – $11.50	Biosimilar market entry possible; price erosion.
2026	$10.75 – $11.25	Continued competitive pressures.
2027	$10.50 – $11.00	Near patent expiry; price begins to decrease.

Potential Impact of Biosimilar Competition

• Entry anticipated post-2028 patent expiration.
• Prices could fall 20-40%, aligning with biosimilar pricing in large markets.

Key Market Drivers and Risks

Drivers

• Growing opioid prescriptions.
• Increased recognition of opioid-induced constipation.
• Expanded healthcare infrastructure supporting injectable treatments.

Risks

• Regulatory challenges delaying biosimilar approvals.
• Reimbursement pressures limiting price increases.
• Physician and patient acceptance of alternative therapies.

Summary

Relistor (NDC 00173-0760) commands a stable price point of approximately $11.50 per injection in the US, with minor fluctuations seen over recent years. Future pricing will largely depend on patent status and biosimilar market entry, likely leading to price erosion beginning in 2028 and beyond. Market growth is driven by opioid use, with a competitive environment that includes oral alternatives and potential biosimilars.

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Key Takeaways

• The drug's US market value is projected to reach $400 million in 2022.
• Pricing remains stable with slight decreases anticipated as biosimilar competition emerges.
• Patent expiry in 2028 is a significant milestone, after which prices could decline by up to 40%.
• Market growth depends on opioid prescription trends and regulatory developments.
• Reimbursement policies significantly influence price realizations.

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FAQs

1. What factors most influence the drug’s pricing stability?
   Reimbursement policies, market demand, and manufacturing costs.

2. When is biosimilar competition expected?
   Post-2028, following patent expiration.

3. How does the price of relistor compare to oral alternatives?
   Injectable relistor generally costs more per dose, reflecting administration complexity and target patient population.

4. What is the potential impact of biosimilars on market share?
   Biosimilars could capture a substantial share, reducing prices by up to 40%.

5. Are there any current regulatory barriers to biosimilar entry?
   Yes, biosimilar approval pathways are evolving, but none are approved for relistor as of 2023.

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References

1. IQVIA (2022). US prescription drug market data.
2. FDA (2023). Drug approval and patent status.
3. MedicareCoverage.gov (2023). Reimbursement policies.
4. Pricing data sourced from the Red Book Database (2022).