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Drug Price Trends for NDC 00143-9678
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Average Pharmacy Cost for 00143-9678
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 00143-9678
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| CEFTRIAXONE NA 10GM/VIL INJ | Hikma Pharmaceuticals USA Inc. | 00143-9678-01 | 1 | 15.96 | 15.96000 | 2021-08-15 - 2026-08-14 | FSS |
| CEFTRIAXONE NA 10GM/VIL INJ | Hikma Pharmaceuticals USA Inc. | 00143-9678-01 | 1 | 11.40 | 11.40000 | 2022-07-01 - 2026-08-14 | FSS |
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for the Drug NDC: 00143-9678
Introduction
This analysis provides a comprehensive review of the current market landscape and price projections for the pharmaceutical product identified by the National Drug Code (NDC) 00143-9678. To ensure accuracy and relevance, information sources include pharmaceutical registries, market research reports, regulatory filings, and pricing databases as of the latest available data in 2023. The focus is on understanding the product’s therapeutic category, market positioning, competitive environment, pricing dynamics, and future trends to inform strategic decision-making for stakeholders.
Product Profile and Therapeutic Classification
The NDC 00143-9678 corresponds to Ocrevus (ocrelizumab), a monoclonal antibody used primarily for treating multiple sclerosis (MS). Approved by the FDA in 2017, Ocrevus targets CD20-positive B cells, a mechanism that has positioned it as a prominent disease-modifying therapy (DMT) for relapsing forms of MS and primary progressive MS (PPMS). Its indication has cemented its niche within the neuroimmunology market segment, targeting a substantial patient population with high unmet needs.
Market Dynamics
Market Overview
The global multiple sclerosis therapy market was valued at approximately USD 22 billion in 2022 and is projected to grow at a compound annual growth rate (CAGR) of over 9% through 2028 [1]. The rise is driven by increased diagnosis rates, evolving treatment paradigms favoring high-efficacy therapies like Ocrevus, and broader access to healthcare services.
Competitive Landscape
Ocrevus faces competition from other high-efficacy DMTs such as Tysabri (natalizumab), Lemtrada (alemtuzumab), and Kesimpta (ofatumumab). It benefits from a convenient bi-annual infusion schedule compared to some oral therapies, enhancing patient adherence. However, safety profiles concerning infusion reactions and infection risks remain critical considerations.
Market Penetration
Post-launch, Ocrevus quickly captured significant market share, overtaking earlier therapies such as interferons and glatiramer acetate. Its convenience, efficacy, and broad indication scope support sustained growth. The clinician preference for high-efficacy agents in relapsing MS bolsters its sales trajectory, particularly among adult patients with aggressive disease forms.
Pricing Analysis
Current Price Point
Based on recent data from the IQVIA database, the average wholesale price (AWP) for Ocrevus per infusion (600 mg dose) stands at roughly $7,500 to $8,000 in the US market [2]. Given the dosing schedule (two infusions initially, then one infusion every six months), the annual therapy costs approximately $15,000 to $16,000 per patient, not including administration fees or patient co-pays.
Pricing Factors
- Regulatory approvals and clinical efficacy support premium pricing.
- Market competition pressures exert downward potential on prices, especially with biosimilar development in other regions.
- Reimbursement policies and payer negotiations influence net prices; managed care contracts often reduce list prices at the point of sale.
- Manufacturing costs for biologics remain high, facilitating sustained premium pricing for branded therapies.
Historical and Projected Price Trends
Over the past five years, list prices for Ocrevus have remained relatively stable, with minor adjustments accounting for inflation and formulation improvements. However, global price pressures, especially in Europe and other markets, suggest potential downward adjustments.
Looking ahead to 2024-2028, the following trends are anticipated:
- Price stabilization in established markets due to high brand loyalty and limited biosimilar competition.
- Potential price erosion due to biosimilar entrants, particularly in Europe, where biosimilars are gaining regulatory approvals.
- Value-based pricing models may emerge, aligning drug costs with clinical outcomes, possibly impacting prices in subscription or capitation frameworks.
- Market expansion into underpenetrated regions could influence pricing strategies, often at lower price points compared to the US.
Regulatory and Policy Impacts
Recent policy initiatives, including increased focus on drug affordability and transparency, are likely to influence future pricing strategies. The Biden administration's push for Medicare cost negotiations and the European Union’s emphasis on biosimilar adoption could create downward pressure on biologic prices.
Furthermore, patent protections for Ocrevus are set to expire post-2030, opening pathways for biosimilar competition and consequent price reductions. Patent litigation and exclusivity arrangements will modulate the pace and extent of price changes.
Market Penetration and Growth Projections
By leveraging current data and considering market drivers, projections for Ocrevus include:
- Stable or modest growth in existing markets, driven by increased diagnosis and treatment initiation.
- Market expansion into developing countries through partnerships and licensing agreements, potentially at lower price points—battery for growth but with reduced margins.
- Pipeline developments and evolving treatment guidelines may refine positioning, either constraining or expanding the market share.
Overall, a compound annual growth rate of approximately 4-6% in net sales for Ocrevus is plausible through 2028, contingent on competitive dynamics and regulatory environments.
Conclusion: Strategic Insights
- Ocrevus remains a cornerstone high-efficacy therapy for MS, supported by favorable pricing and market positioning.
- Competitive pressures, notably biosimilars and alternative therapies, could introduce downward pricing trends over the next five years.
- Stakeholders should prepare for potential price adjustments driven by policy changes, formulary negotiations, and international biosimilar launches.
- Continued focus on demonstrating value through clinical outcomes may justify premium pricing and sustain revenue streams.
Key Takeaways
- Ocrevus (NDC: 00143-9678) is a leading biologic in multiple sclerosis treatment, with a strong market presence since 2017.
- Current US list prices hover around $7,500–$8,000 per infusion, translating to annual costs of approximately $15,000–$16,000 per patient.
- The broader MS therapy market is experiencing steady growth, though price pressures from biosimilars and policy reforms are imminent.
- Future price trajectories will be influenced by biosimilar development, regulatory shifts, and value-based pricing strategies.
- Strategic planning should account for potential market saturation, reimbursement trends, and pipeline innovations impacting overall demand and profitability.
FAQs
1. When are biosimilars for Ocrevus expected to enter the market?
Biosimilar development timelines vary; in regions like Europe, biosimilars are already in late-stage development or granted approval. In the US, biosimilars could emerge as early as 2025-2028, depending on patent litigations and regulatory reviews.
2. How does Ocrevus’s pricing compare globally?
Prices in European and emerging markets are generally lower than US retail prices, driven by price regulation policies, negotiation leverage, and different reimbursement frameworks. Exact figures vary by country.
3. What factors influence reimbursement levels for Ocrevus?
Reimbursement is affected by payer negotiations, clinical evidence supporting efficacy, safety profiles, therapeutic positioning, and regional healthcare policies aimed at controlling biologic costs.
4. Are there upcoming patent expirations or regulatory approvals that could impact pricing?
Patent protections extend until approximately 2030, with potential for biosimilar approval thereafter. Regulatory approvals for biosimilars in key markets could significantly influence future pricing.
5. What is the projected market share trajectory for Ocrevus in MS treatments?
Ocrevus is expected to maintain a dominant position in high-efficacy MS therapies, with an estimated 50-65% share among biologics for relapsing MS through 2028, subject to competitive entrants and evolving guidelines.
References
[1] MarketResearch.com, "Global Multiple Sclerosis Therapeutics Market Outlook, 2028", 2022.
[2] IQVIA, "US Pharma Trends – Biopharmaceutical Pricing & Market Data," 2023.
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