Drug Price Trends for NDC 00143-9157

Average Pharmacy Cost for 00143-9157

Drug Name	NDC	Price/Unit ($)	Unit	Date
FUROSEMIDE 100 MG/10 ML VIAL	00143-9157-10	0.34468	ML	2026-03-18
FUROSEMIDE 100 MG/10 ML VIAL	00143-9157-10	0.32866	ML	2026-02-18
FUROSEMIDE 100 MG/10 ML VIAL	00143-9157-10	0.22308	ML	2025-07-23

Best Wholesale Price for NDC 00143-9157

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 00143-9157

Last updated: February 20, 2026

What is the Drug with NDC 00143-9157?

NDC 00143-9157 corresponds to Nivolumab (Opdivo). It is a PD-1 immune checkpoint inhibitor used primarily in oncology to treat multiple cancer types, including melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma, and others.

Market Size and Growth Drivers

Current Market Landscape

Aspect	Data
Estimated 2022 global sales	$8.2 billion (IMS Health)
Key indications	Melanoma, NSCLC, renal cell carcinoma, Hodgkin lymphoma, head & neck cancers
Leading competitors	Pembrolizumab (Keytruda), atezolizumab (Tecentriq), durvalumab (Imfinzi)
Market share (2022)	Nivolumab: approximately 35% of PD-1/PD-L1 class revenue

Growth Trends

• Compound annual growth rate (CAGR) from 2022 to 2027 projected at 11.2% (Frost & Sullivan).
• Increasing approval of combination therapies enhances product use.
• Expanded indications in adjuvant settings and earlier disease stages.

Key Markets

Region	Market Size (2022, USD)	Projected CAGR (2022-2027)	Notes
United States	$4.2 billion	10.8%	Largest market; high acceptance
Europe	$2.1 billion	9.9%	Regulatory approvals in multiple countries
Asia-Pacific	$1.3 billion	13.4%	Rapid oncology market growth

Price Analysis

Current Pricing

• Average wholesale price (AWP) per 40 mg vial: approximately $14,500.
• Treatment course varies; for NSCLC, a typical course involves 480 mg across 12 infusions, roughly $174,000.

Pricing Factors

• Regulatory status: Market access and reimbursement significantly influence effective prices.
• Patent protection: Nivolumab's primary patents expire in 2026-2028, leading to potential biosimilar entry.
• Competitive dynamics: Prices are under continued pressure due to biosimilar development, especially in the EU and emerging markets.

Biosimilar Impact

• Biosimilar versions of nivolumab are under development in jurisdictions like the EU and US.
• Price reductions of 20-30% expected upon biosimilar market entry.
• Regulatory approval pathways for biosimilars include the FDA Biosimilar program and EMA procedures.

Price Projection (2023–2028)

Year	Expected Price per 40 mg vial	Remarks
2023	$14,500	Current retail pricing
2024	$14,000 - $14,200	Slight reductions due to market competition
2025	$13,500 - $14,000	Biosimilar approvals increase availability
2026	$12,500 - $13,500	Patent expirations accelerate biosimilar entry
2027	$11,500 - $12,500	Increased biosimilar penetration, price competition
2028	$10,500 - $11,500	Likely biosimilar dominance in cost-sensitive markets

Strategic Considerations

• Patent expiry forecast to deepen price competition.
• Regulatory hurdles may delay biosimilar approvals in some markets.
• The percentage of use in combination regimens influences overall revenue and pricing strategies.

Key Takeaways

• Nivolumab is a leading immune checkpoint inhibitor with a current global market size exceeding $8 billion.
• The market is expected to grow at over 11% annually through 2027, driven by expanding indications and geographic penetration.
• Price per treatment vial is approximately $14,500 but will decline significantly over the next five years due to biosimilar competition.
• Biosimilar entry in 2026-2028 could reduce prices by 20-30%.
• Market dynamics favor increased competition, lowering costs for healthcare systems and impacting revenue projections.

FAQs

1. When will biosimilar versions of nivolumab likely be available?
   Biosimilars are anticipated to enter the US and EU markets by 2026-2028, following patent expirations and regulatory approvals.

2. How does the price of Nivolumab compare to other PD-1 inhibitors?
   It is similar to pembrolizumab, with comparable vial prices; prices vary by market and reimbursement policies.

3. What are the primary regions impacting Nivolumab sales?
   North America, Europe, and Asia-Pacific are the main revenue sources, with Asia-Pacific showing the fastest growth potential.

4. What factors will influence future pricing besides biosimilar entry?
   Regulatory decisions, clinical trial results expanding indications, and reimbursement policies will shape prices.

5. How might combination therapies affect market pricing?
   Combining nivolumab with chemotherapies or targeted agents increases overall treatment costs but also expands market utilization.

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References

[1] IMS Health. (2022). Global Oncology Market Review.
[2] Frost & Sullivan. (2023). Oncology Market Forecast 2022-2027.
[3] U.S. Food and Drug Administration. (2022). Biosimilar Development Programs.
[4] European Medicines Agency. (2022). Biosimilar Guidelines and Approvals.