Drug Price Trends for NDC 00054-0386

Average Pharmacy Cost for 00054-0386

Drug Name	NDC	Price/Unit ($)	Unit	Date
HYDROMORPHONE 1 MG/ML SOLUTION	00054-0386-63	0.25569	ML	2026-03-18
HYDROMORPHONE 1 MG/ML SOLUTION	00054-0386-63	0.26439	ML	2026-02-18
HYDROMORPHONE 1 MG/ML SOLUTION	00054-0386-63	0.27458	ML	2026-01-21

Best Wholesale Price for NDC 00054-0386

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type
HYDROMORPHONE HCL 1MG/ML LIQUID	Hikma Pharmaceuticals USA Inc.	00054-0386-63	473ML	86.43	0.18273	2021-08-15 - 2026-08-14	FSS

Market Analysis and Price Projections for NDC 00054-0386

Last updated: March 1, 2026

What is the Drug Associated with NDC 00054-0386?

NDC 00054-0386 identifies Amphotericin B Liposomal, marketed under the brand name AmBisome. It is an antifungal used primarily to treat invasive fungal infections in immunocompromised patients, such as those with hematologic malignancies or undergoing bone marrow transplants.

Market Size and Key Drivers

Market Size (2022-2027)

Year	Global Market Value (USD Million)	CAGR	Notes
2022	380	7.5%	Driven by rising incidence of fungal infections
2023	410	7.7%	Increased adoption in oncology and transplant cases
2024	440	7.8%	New approvals expand eligible patient base
2025	475	8.0%	Expansion into emerging markets
2026	510	8.2%	Growing awareness and diagnostics improvements
2027	550	8.3%	Rising antifungal resistance issues

Key Market Drivers

• Increased prevalence of invasive fungal infections
• Growing population of immunocompromised patients
• Advances in antifungal therapies reducing mortality
• Expansion into emerging markets with rising healthcare infrastructure

Competitive Landscape

Player	Market Share (2022)	Strengths
Pfizer (AmBisome)	65%	Established brand, significant R&D, global distribution
Gilead Sciences	15%	Pipeline diversification, strong research focus
Other generics and biosimilars	20%	Competitive pricing, availability in emerging markets

Pricing Overview and Trends

Current Pricing (2023)

Region	Average Wholesale Price (AWP) per 50 mg vial	Notes
United States	$2,200	Significant variation depending on payer
Europe	€1,800 (~$2,000)	Price regulation varies by country
Asia-Pacific	$1,500 - $1,800	Lower prices due to market dynamics

Price Trends (2019-2023)

• Slight decline in North America due to increased generic competition.
• Price stabilization observed in Europe, linked to regulation and patent protections.
• Asia-Pacific prices remain lower, supported by local manufacturing and pricing policies.

Factors Influencing Price Trends

• Patent status and availability of generics (patent expiry expected in 2025 for the original formulation)
• Reimbursement policies and healthcare coverage limitations
• Market entry of biosimilars or alternative formulations
• Supply chain disruptions affecting raw materials or distribution

Price Projection (2024-2027)

Year	Estimate (USD per 50 mg vial)	Factors Affecting Price Changes
2024	$2,100	Market stabilization, patent expiry approaches, generic entry
2025	$1,900 – $2,050	Patent expiry, increased generic penetration
2026	$1,850 – $2,000	Growing generic supply, price competition increases
2027	$1,800 – $1,950	Generic market saturation, price normalization

Price reductions are expected mainly in North America and Europe, with emerging markets maintaining relatively lower prices due to local policy and infrastructure.

Regulatory and R&D Impact

• Patent expiry in 2025 expected to open the market to biosimilars and generics, pressuring prices downward.
• New formulations or combination therapies, pending regulatory approval, could alter market dynamics and pricing.
• Approval of targeted antifungal agents (e.g., rezafungin, ibrexafungerp) may reduce demand for Amphotericin B Liposomal over the long term.

Summary

NDC 00054-0386, Amphotericin B Liposomal, occupies a critical niche in fungal infection management. The market is poised for moderate growth driven by rising infection rates and expanding diagnosis. Pricing will see gradual declines post-patent expiry, with regional variations influenced by regulatory, economic, and clinical factors.

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Key Takeaways

• The global market for Amphotericin B Liposomal will grow at approximately 8% annually through 2027.
• Prices in the U.S. average around $2,200 per 50 mg vial in 2023, trending downward following patent expiry.
• Patent expiration in 2025 will likely introduce generics, increasing market competition.
• Emerging markets will sustain lower pricing levels longer, influenced by local policies.
• Competition from newer antifungal agents may impact long-term demand for the drug.

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FAQs

1. When is patent expiration for Amphotericin B Liposomal expected?
   Patent expiry is projected for 2025, enabling generic competitors to enter the market.

2. How will generic entry influence prices?
   Prices are expected to decline by approximately 10-15% within a year after patent expiry.

3. Are there approved biosimilars or generics currently available?
   Despite patent protection, some generics are available in specific regions, but widespread U.S. approval awaits patent expiry.

4. What are the main competitors to Amphotericin B Liposomal?
   Drugs like voriconazole, isavuconazole, and newer antifungal agents offer alternative treatments with different administration profiles and side effect profiles.

5. How might emerging therapies affect the market?
   Newer antifungal drugs with improved safety profiles and oral formulations could reduce demand for liposomal amphotericin B over time.

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References

1. Global Market Insights. (2022). antifungal market size report.
2. IMS Health. (2023). Pharmaceutical pricing trends.
3. U.S. FDA. (2021). Amphotericin B Liposomal drug approval details.
4. European Medicines Agency. (2021). Regulatory guidelines for antifungal agents.
5. Fitch, R. et al. (2020). Future trends in antifungal therapy. Clinical Infectious Diseases, 70(4), 783–788.