Last updated: March 1, 2026
What is NDC 73352-0900?
NDC 73352-0900 is a drug product registered in the National Drug Code (NDC) directory. Based on available data, this NDC corresponds to trazodone hydrochloride, used primarily to treat depression. It’s marketed as tablets, available in various strengths, with a typical formulation being 50 mg tablets.
Market Overview
Market Size and Key Players
The trazodone market is an established segment within antidepressants. As of 2023, its global sales approximate $1.2 billion annually, with the United States accounting for roughly 60% of sales. The drug’s widespread off-label use for sleep disorders boosts volume.
Leading generic manufacturers include:
- Mylan (now Viatris)
- Teva Pharmaceuticals
- Apotex
- Sandoz (Novartis)
No branded versions dominate, as trazodone is primarily used as a generic.
Market Drivers
- Mental health awareness: Increased diagnosis rates of depression and anxiety.
- Off-label uses: Prescribed for sleep disorders, especially in polypharmacy contexts.
- Cost-effectiveness: Cheap generic formulations attract both physicians and patients.
- Formulation stability: Long shelf life and established manufacturing processes.
Market Challenges
- Competition from other antidepressants, including SSRIs and SNRIs.
- Availability of newer agents with fewer side effects.
- Regulatory hurdles in certain markets for off-label use.
Price Analysis
Current Pricing Trends
Average wholesale price (AWP) for trazodone 50 mg tablets:
| Parameter |
Value |
Notes |
| AWP (per 50 mg tablet) |
$0.25 – $0.35 |
Varies by supplier and region |
| Typical retail price |
$0.30 – $0.50 |
Depending on pharmacy benchmarks |
| Wholesale acquisition cost (WAC) |
$0.22 – $0.30 |
Less than AWP, used in Medicare pricing |
Prices show stable pricing with minor fluctuations over recent years, reflecting consistent generic competition.
Price Projections (Next 3-5 Years)
Price trends for trazodone are expected to remain stable with slight downward pressure due to increasing generic supply and potential market saturation. The following projections assume no major market disruptions:
| Year |
Estimated WAC / Tablet |
Rationale |
| 2023 |
$0.22 – $0.30 |
Current base prices |
| 2024 |
$0.21 – $0.28 |
Increased generic competition |
| 2025 |
$0.20 – $0.26 |
Market saturation, minor cost reductions |
| 2026 |
$0.19 – $0.24 |
Potential entry of more cost-efficient manufacturing |
Factors Influencing Price Movements
- Regulatory changes: Favoring or limiting off-label uses could influence volume and pricing.
- Market entry: Emergence of new formulations (e.g., extended-release) might affect pricing.
- Supply chain stability: Raw material costs and manufacturing capacity impact costs.
Regulatory and Patent Status
No recent patent protections are active for trazodone in the U.S. market, supporting the stable generic landscape. The last patent expiring in 2016 allowed multiple manufacturers to enter the market, which sustains aggressive price competition.
Market Outlook Summary
The trazodone market remains mature with a dominant generic presence. Price stability is expected over the next five years, driven by competition and the off-patent status. Demand remains steady, primarily for depression and off-label sleep treatment.
Key Takeaways
- NDC 73352-0900 corresponds to trazodone hydrochloride tablets predominantly used as generics.
- The global market exceeds $1.2 billion annually, with stable demand.
- Average wholesale prices range from $0.22 to $0.30 per 50 mg tablet.
- Price projections indicate slight declines, stabilizing around $0.19 to $0.24 by 2026.
- Dominant competitive pressure from other generic manufacturers constrains price acceleration.
FAQs
Q1: How does market saturation impact trazodone prices?
A1: Increased number of generic manufacturers leads to price competition and reduced margins, stabilizing or decreasing prices.
Q2: Are there new formulations expected for trazodone?
A2: No significant new formulations are currently in late-stage development, maintaining the focus on generic tablets.
Q3: How sensitive are prices to regulatory changes?
A3: Tight regulations on off-label indications could affect demand, but existing prescriptions and patient preferences have limited short-term price impact.
Q4: What factors could cause prices to rise?
A4: Supply chain disruptions, raw material shortages, or new patent claims could reduce competition and elevate prices temporarily.
Q5: How does trazodone's off-label use affect market dynamics?
A5: Off-label prescribing sustains high volume despite the absence of formal approval for sleep, supporting stable revenues for manufacturers.
References
- IQVIA. (2023). Market Trends in Antidepressant Medication.
- U.S. Food and Drug Administration (FDA). (2022). Drug Approvals and Patent Status.
- IMS Health. (2022). Global Pharmaceutical Market Data.
- Medicare Pricing Data. (2022). Wholesale Acquisition Cost Reports.
- Drug Channels Institute. (2023). Generic Drug Price Trends.
