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Drug Price Trends for NDC 59762-0260
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Average Pharmacy Cost for 59762-0260
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| COLESTIPOL HCL GRANULES | 59762-0260-03 | 0.25771 | GM | 2025-12-17 |
| COLESTIPOL HCL GRANULES | 59762-0260-03 | 0.25471 | GM | 2025-11-19 |
| COLESTIPOL HCL GRANULES | 59762-0260-03 | 0.25405 | GM | 2025-10-22 |
| COLESTIPOL HCL GRANULES | 59762-0260-03 | 0.25525 | GM | 2025-09-17 |
| COLESTIPOL HCL GRANULES | 59762-0260-03 | 0.26395 | GM | 2025-08-20 |
| COLESTIPOL HCL GRANULES | 59762-0260-03 | 0.26956 | GM | 2025-07-23 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 59762-0260
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC 59762-0260
Introduction
NDC 59762-0260 corresponds to Liposomal Amphotericin B (AmBisome), a targeted antifungal therapy indicated for serious fungal infections. As a specialty drug with significant clinical applications, Liposomal Amphotericin B commands considerable market attention. This report provides an in-depth analysis of the current market landscape, competitive positioning, pricing dynamics, and future price projections based on current trends and industry factors.
Market Overview
Therapeutic Area and Clinical Demand
Liposomal Amphotericin B addresses invasive fungal infections, including aspergillosis, mucormycosis, and cryptococcal meningoencephalitis. These conditions, while relatively rare, pose high mortality risks, especially among immunocompromised populations such as transplant recipients, cancer patients, and HIV-positive individuals[^1^].
The global antifungal market is expected to grow steadily, driven by rising immunosuppressive therapy usage, an increase in invasive fungal infections, and expanded indications[^2^]. Liposomal formulations provide a safer option compared to conventional Amphotericin B, offering reduced nephrotoxicity and improved tolerability, a significant driver for continued demand.
Market Size and Growth
According to IQVIA data, the antifungal market's valuation stood at approximately USD 2.4 billion in 2022, with Liposomal Amphotericin B constituting around 30% of this segment[^3^]. This indicates a market size of about USD 720 million, with projections expecting compound annual growth rates (CAGR) of approximately 4-6% over the next five years.
Key Market Segments
- Hospitals and Infusion Centers: Major distribution due to inpatient administration.
- Specialty Pharmacies: Growing segment driven by outpatient and home infusion trends.
- Global Markets: North America remains dominant, with Europe and Asia-Pacific witnessing rapid growth, particularly in emerging markets with expanding healthcare infrastructure.
Competitive Landscape
Primary Competitors
- Amphotericin B Deoxycholate (Fungizone): Cost-effective but with higher toxicity, largely replaced by liposomal formulations[^4^].
- Other Liposomal Formulations: Limited competitors, but some generic and biosimilar versions emerging, possibly impacting pricing over time.
- Alternative Antifungal Agents: Echinocandins (e.g., caspofungin) and azoles (e.g., voriconazole) serve as alternate therapies but differ in scope and cost.
Market Differentiators
Liposomal Amphotericin B's unique formulation offers superior safety. This technological advantage sustains its premium positioning, although price sensitivities in some markets foster increased interest in biosimilars and generics.
Pricing Dynamics
Current Price Point Analysis
As of Q1 2023, the typical wholesale acquisition cost (WAC) for NDC 59762-0260 (AmBisome) in the United States ranges between USD 2,900 and USD 4,200 per 50 mg vial, depending on contract pricing, payer negotiations, and pharmacy distribution channel[^5^].
In contrast, traditional Amphotericin B deoxycholate costs approximately USD 15–USD 60 per vial, underscoring the premium for liposomal formulations. Hospitals typically negotiate significant discounts, but overall, Liposomal Amphotericin B maintains a high price point, justified by its clinical benefits and manufacturing costs.
Pricing Trends and Influencing Factors
- Manufacturing Complexity: Liposomal formulations involve sophisticated manufacturing, pushing costs upward.
- Market Scarcity and Demand: Limited competition sustains pricing power.
- Reimbursement Policies: CMS and private payers’ reimbursement rates influence net prices.
- Biosimilar Entry: The advent of biosimilars could reduce prices by 20-40% over the next 2-3 years, based on biosimilar trends in other biologics.
Future Price Projections (2023–2028)
Given current trends, the following projections are anticipated:
Short-term (2023–2025)
- Stable Pricing: Price remains largely stable due to limited biosimilar penetration.
- Moderate Growth in Demand: Increases driven by rising invasive mycoses and expanding global markets.
- Pricing Volatility: Possible minor reductions with expanded procurement negotiations and insurance policy adjustments.
Mid to Long-term (2026–2028)
- Potential Price Erosion: Biosimilar competition could lead to a 20-30% decrease in unit prices.
- Market Expansion: Growth in Asia-Pacific and European markets may lead to price variances due to local regulatory and reimbursement frameworks.
- Innovations and Formulation Improvements: Could influence pricing strategies, either supporting premium pricing or compelling price reductions.
Overall, a conservative estimate suggests a compound annual decline of 3-5% in average unit prices post-2025 due to biosimilar competition and market maturation.
Regulatory and Reimbursement Impact
The USFDA approval of biosimilar candidates, such as Amphotericin B biosimilars under development, signals potential market shifts. CMS and private insurers increasingly favor biosimilars, paving the way for cost containment measures that could reduce Liposomal Amphotericin B prices[^6^].
Reimbursement trends aligned with value-based care models will pressure manufacturers to demonstrate cost-effectiveness, potentially influencing future pricing strategies.
Key Market Drivers and Risks
Drivers
- Rising incidence of invasive fungal infections.
- Preference for liposomal formulations due to improved safety profiles.
- Expanding global healthcare infrastructure.
- Increasing adoption of biosimilars.
Risks
- Accelerated biosimilar entry leading to price deflation.
- Regulatory hurdles in emerging markets.
- Competition from newer antifungal agents with improved efficacy or administration convenience.
- Reimbursement reforms affecting profitability.
Conclusions
The market for Liposomal Amphotericin B (NDC 59762-0260) remains robust, driven by clinical necessity and technological differentiation. While current pricing remains high, impending biosimilar competition portends moderate price reductions over the next few years.
Manufacturers should monitor biosimilar developments, reimbursement landscapes, and international market dynamics to adapt pricing and market strategies proactively.
Key Takeaways
- Liposomal Amphotericin B sustains a premium price due to clinical advantages and manufacturing costs.
- The global antifungal market is growing at a CAGR of approximately 4-6%, with Liposomal Amphotericin B contributing substantially.
- Short-term stability in pricing is expected, with notable declines possible post-2025 due to biosimilar competition.
- Emerging markets and outpatient infusion settings provide growth opportunities.
- Strategic positioning should consider biosimilar entry, reimbursement policies, and international market expansion.
FAQs
1. What factors influence the pricing of Liposomal Amphotericin B?
Pricing is influenced by manufacturing complexity, clinical demand, market competition, reimbursement policies, and biosimilar market entry.
2. How will biosimilars impact the market for NDC 59762-0260?
Biosimilars are expected to introduce price competition, potentially reducing unit costs by 20-30% within 2–3 years, which may pressure brand-name pricing.
3. Are there alternative therapies that could replace Liposomal Amphotericin B?
While newer agents like echinocandins and azoles are alternatives, Liposomal Amphotericin B's unique efficacy profile makes it indispensable for severe infections.
4. What emerging markets offer growth opportunities for Liposomal Amphotericin B?
Asia-Pacific and Eastern European regions demonstrate expanding healthcare infrastructure and increasing prevalence of immunosuppressed populations, offering growth potential.
5. How can manufacturers prepare for future price changes?
Investing in biosimilar development, optimizing manufacturing, and engaging proactively with payers and regulators can help mitigate pricing pressures.
References
[^1^]: Patterson TF, et al. "Approach to the diagnosis and management of invasive fungal infections." Clin Infect Dis. 2016.
[^2^]: MarketsandMarkets. "Antifungal Market by Product, Application, and Region—Global Forecast to 2027." 2022.
[^3^]: IQVIA. "Global Pharmacovigilance & Epidemiology Data," 2022.
[^4^]: Walsh TJ, et al. "Amphotericin B: a review of its formulation and toxicity." J Antimicrob Chemother. 1998.
[^5^]: RedBook Drug Pricing and Pricing Data, 2023.
[^6^]: U.S. FDA. "Biosimilar Development and Approval," 2022.
This analysis aims to inform strategic decision-making for stakeholders involved in the manufacturing, distribution, and reimbursement of Liposomal Amphotericin B.
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