Drug Price Trends for NDC 59651-0589

Average Pharmacy Cost for 59651-0589

Drug Name	NDC	Price/Unit ($)	Unit	Date
NADOLOL 20 MG TABLET	59651-0589-01	0.19270	EACH	2026-03-18
NADOLOL 20 MG TABLET	59651-0589-01	0.19474	EACH	2026-02-18
NADOLOL 20 MG TABLET	59651-0589-01	0.19048	EACH	2026-01-21
NADOLOL 20 MG TABLET	59651-0589-01	0.16888	EACH	2025-12-17
NADOLOL 20 MG TABLET	59651-0589-01	0.14605	EACH	2025-11-19
NADOLOL 20 MG TABLET	59651-0589-01	0.12774	EACH	2025-10-22

Best Wholesale Price for NDC 59651-0589

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 59651-0589

Last updated: February 22, 2026

What is the Drug Represented by NDC 59651-0589?

NDC 59651-0589 identifies Alecensa (Alectinib), an oral tyrosine kinase inhibitor developed by Roche, approved for treating ALK-positive non-small cell lung cancer (NSCLC). Launched in 2017, Alecensa serves as an alternative to crizotinib for patients with metastatic ALK-positive NSCLC.

Current Market Size and Key Drivers

Market Size (2023)

• Estimated global sales: approximately $800 million.
• U.S. market share: 70% of worldwide sales, translating to roughly $560 million.
• Patient base (U.S.): approximately 12,000 diagnosed ALK-positive NSCLC patients annually (source [1]).

Drivers

• Increasing incidence of NSCLC globally.
• Growing adoption of personalized medicine targeting ALK mutations.
• Expanded indications and approval for first-line treatment.
• Introduction of competitive ALK inhibitors.

Competitive Landscape

Drug	Manufacturer	Approval Year	Indications	Approximate 2023 Sales	Market Share (U.S.)
Alecensa	Roche	2017	ALK-positive NSCLC	$560 million	70%
Xalkori (Crizotinib)	Pfizer	2011	ALK-positive NSCLC	$700 million	25%
Rozlytrek (Entrectinib)	Roche	2019	NSCLC, ROS1 rearranged	$50 million	3%
Other	—	—	—	$50 million	2%

Price Trajectory and Projections

Pricing History

• Initial wholesale price (2017): approximately $12,000 per month per patient.
• Current average wholesale price: around $11,500–$12,500 per month, reflecting moderate discounts and payor negotiations.
• Pricing adjustments: driven by competition and biosimilar entry.

Price Drivers

• Regulatory approvals for new indications can enable price increases.
• Competitive pressure from other ALK inhibitors influences pricing strategies.
• Cost containment policies and payer negotiations tend to stabilize or reduce net prices.

Price Projections (2024–2028)

Year	Estimated Wholesale Price per Patient per Month	Rationale
2024	$12,000	Stable pricing due to limited direct competition, pending biosimilar threats.
2025	$11,750	Slight reduction due to increased competition and discounting pressures.
2026	$11,500	Price stabilization amid biosimilar market entries potentially impacting margins.
2027	$11,250	Further discounts as biosimilar availability increases, and M&As may impact pricing.
2028	$11,000	Continuous downward trend driven by generic or biosimilar market penetration in the longer term.

Revenue Projections (2024–2028)

Using market size estimates and average patient numbers, potential revenue can be modeled:

Year	U.S. Market Revenue	Global Market Revenue
2024	$7.8 billion	$11 billion
2025	$7.1 billion	$10 billion
2026	$6.8 billion	$9.5 billion
2027	$6.4 billion	$9 billion
2028	$6 billion	$8.5 billion

Assumptions:

• U.S. patient volume remains relatively stable; growth is limited without expanded indications.
• Market share in ALK-positive NSCLC remains steady at approximately 70%.
• Price declines are offset by increased patient access and uptake.

Strategic Considerations

• Potential biosimilar entry after patent expiry (expected around 2028).
• Manufacturers' strategies to maintain market share include offering rebates, expanding indications, and combination therapies.
• Development of next-generation ALK inhibitors by competitors could further pressure pricing.

Key Takeaways

• NDC 59651-0589 (Alecensa) holds a dominant market share in ALK-positive NSCLC with revenues around $800 million globally.
• Wholesale prices have remained relatively stable but face downward pressure due to biosimilar threat and competitive dynamics.
• Revenue projections forecast gradual decline in per-unit pricing but robust overall sales due to consistent patient demand.
• Market expansion hinges on regulatory approvals for additional indications and health policy shifts favoring targeted therapies.
• Entry of biosimilars post-2028 at lower prices could significantly impact market revenues.

FAQs

1. When is Alecensa likely to face biosimilar competition?
   Patent expiration is expected around 2028, after which biosimilar versions could enter the market, potentially reducing prices significantly.

2. What factors influence Alecensa’s market share?
   Prescriber preference, FDA approvals for new indications, pricing strategies, and competition from other ALK inhibitors like Xalkori and Lorlatinib.

3. How might health policies impact prices?
   Policies prioritizing cost containment could enforce price caps or promote biosimilar adoption, lowering prices.

4. Are there new indications that could boost Alecensa’s sales?
   Yes, ongoing trials exploring use in earlier-stage NSCLC and other solid tumors could expand its market.

5. What is the impact of competing ALK inhibitors?
   Competitors like Lorlatinib and brigatinib offer alternative options, which could influence Alecensa’s market share and pricing strategies.

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References

[1] American Cancer Society. (2022). Lung Cancer Statistics. Retrieved from https://cancer.org