Last updated: February 25, 2026
What is the Drug Associated with NDC 51759-0520?
The National Drug Code (NDC) 51759-0520 corresponds to Bupropion Hydrochloride Extended-Release (SR), 100 mg. It is marketed under brand names such as Wellbutrin SR.
Current Market Landscape
Sales and Market Share
- Market Size: The US antidepressant market was valued at approximately $7.9 billion in 2022, with Bupropion accounting for an estimated 15-20% of the total.
- Sales Trends: Wellbutrin SR generated around $600 million in US sales in 2022, according to IQVIA data.
- Volume: Approximately 45 million prescriptions issued annually in the US for Bupropion formulations, with SR formulations constituting nearly 50%.
Competitive Environment
- Major Competitors: Generic formulations of Bupropion SR, as well as newer agents such as Vortioxetine and Vlayar.
- Patent Status: The primary patent for Wellbutrin SR expired in 2006; subsequent formulations and manufacturing methods are often unpatented or protected through other patents with varying expiration dates.
Regulatory Considerations
- FDA Status: Approved for major depressive disorder (MDD) and seasonal affective disorder (SAD).
- Generics: Multiple generic equivalents are available, driving downward pressure on price.
Price Analysis
Current Pricing
- Brand Name: The average wholesale price (AWP) of Wellbutrin SR 100 mg is approximately $370 for a 30-day supply (30 tablets).
- Generic: Generic Bupropion SR 100 mg typically costs $12-$15 wholesale per month, reflecting a >95% discount relative to the brand.
Reimbursement Pricing
- Medicare/Medicaid: Reimbursements tend to be closer to generic prices.
- Commercial Plans: Negotiated net prices generally lower than wholesale, with pharmacy benefits managers (PBMs) receiving substantial discounts.
Price Projections
Short-term (Next 12 Months)
- Price Stability: Maintains current generic price levels barring patent litigation or supply chain disruptions.
- Brand Price: Slight decrease as market share shifts further toward generics; potential for discounts or rebates.
Long-term (Next 3-5 Years)
- Market Dynamics: Increased prescribing of generics will sustain low prices.
- New Entrants: Entry of biosimilar or alternative formulations could pressure prices further.
- Price Range: Wholesale generic Bupropion SR 100 mg expected to fluctuate between $10 to $20 per 30-day supply, depending on regional and contractual factors.
Influential Factors
- Patent Litigation & Exclusivity: No recent patents protecting the current formulation, so no significant exclusivity is expected.
- Manufacturing Costs: Relatively stable; any addition of new manufacturing processes might temporarily impact pricing.
- Regulatory Changes: Potential policy reforms on drug pricing could influence average prices.
Key Market Risks
- Supply Chain Disruptions: Can cause temporary price increases.
- Regulatory Actions: Reimbursement adjustments or new formulary restrictions can shift market share.
- Market Saturation: Heavy generic penetration limits upside potential.
Summary of Price Outlook Table
| Time Frame |
Price Range (per 30-day supply) |
Key Factors |
| 0-12 months |
$12 - $15 (generic), $370 (brand) |
Market share decline, patents expired |
| 1-3 years |
$10 - $20 (generic) |
Increased generic market penetration |
| 3-5 years |
$10 - $20 |
Market saturation, new competitors |
Key Takeaways
- The drug identified by NDC 51759-0520 is a generic Bupropion SR 100 mg.
- Its market features robust generic competition, leading to low retail prices.
- The brand formulation's price is falling, with no significant patent exclusivity remaining.
- Future pricing will depend on market share trends, regulatory policies, and supply chain factors.
FAQs
1. Will the price of Bupropion SR increase in the next year?
It is unlikely; market conditions favor low prices due to extensive generic availability.
2. Are there upcoming patent protections that could impact pricing?
No; the primary patent expired in 2006, and subsequent patent protections are not currently in place.
3. How does the price compare internationally?
US prices are generally higher; many countries benefit from government-controlled drug pricing, often paying less.
4. What are the main drivers for price reduction in generics?
Market saturation, manufacturing efficiencies, and competitive pressure keep prices low.
5. Can new formulations or delivery methods affect the price?
Potentially; novel formulations with patent protection could command higher prices, but currently, no such formulations exist.
References
[1] IQVIA. (2022). Pharmaceutical Market Data.
[2] FDA. (2023). Drug Approvals and Patents.
[3] Medispan. (2023). Average Wholesale Prices.
[4] Centers for Medicare & Medicaid Services (CMS). (2023). Drug Pricing and Reimbursement.
