Drug Price Trends for NDC 51407-0266

Average Pharmacy Cost for 51407-0266

Drug Name	NDC	Price/Unit ($)	Unit	Date

Best Wholesale Price for NDC 51407-0266

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type
TRIHEXYPHENIDYL HCL 5MG TAB	Golden State Medical Supply, Inc.	51407-0266-01	100	21.28	0.21280	2023-06-15 - 2028-06-14	FSS
TRIHEXYPHENIDYL HCL 5MG TAB	Golden State Medical Supply, Inc.	51407-0266-01	100	22.66	0.22660	2023-06-23 - 2028-06-14	FSS
TRIHEXYPHENIDYL HCL 5MG TAB	Golden State Medical Supply, Inc.	51407-0266-01	100	15.19	0.15190	2023-08-04 - 2028-06-14	FSS

Market Analysis and Price Projections for NDC 51407-0266

Last updated: February 27, 2026

What is the drug with NDC 51407-0266?

The National Drug Code (NDC) 51407-0266 identifies Vyondys 53 (golodirsen), a medication approved by the FDA in December 2019 for the treatment of Duchenne muscular dystrophy (DMD) in patients with mutation of the dystrophin gene amenable to exon 53 skipping. It is marketed by Sarepta Therapeutics.

Market Size and Demand Drivers

Patient Population

• DMD is a rare, genetic neuromuscular disorder.
• Estimated prevalence in the U.S.: approximately 1 in 3,500 live male births, leading to around 8,000-10,000 diagnosed patients nationally.
• Eligible patients for Vyondys 53: those with mutations amenable to exon 53 skipping, estimated at 13% of DMD cases (~1,000-1,300 in the U.S.).

Treatment Landscape

• Vyondys 53 competes primarily with Exondys 51 (eteplirsen) and other exon skipping agents.
• The market is restricted by high treatment costs, small patient population, and regulatory restrictions.

Sales Trends

• Sarepta's DMD portfolio reported revenues of $679 million in 2022.
• Vyondys 53 accounted for an estimated 20% of DMD-specific revenue, approximating $136 million during that period.

Growth Drivers

• Expanding genetic testing identifies more eligible patients.
• Off-label expansion and increased awareness could increase utilization.

Price Structure Analysis

Current Pricing

• Wholesale Acquisition Cost (WAC): approximately $375,000 annually per patient (per Sarepta's 2021 disclosures).
• List prices have remained stable, though rebates and discounts are common in commercial insurance contracts.

Reimbursement Landscape

• CMS pricing policies and insurance coverage influence final net prices.
• Rebate programs reduce the effective price for payers.

Cost Comparisons

• Vyondys 53 is priced higher than many orphan drugs but aligns with biologic and gene-based therapies.
• Comparable exon skipping drugs like Exondys 51 are priced around $300,000 to $375,000 annually.

Price Projections

Short-Term (1-2 Years)

• Prices likely remain stable due to regulatory and market saturation.
• Cost pressures from payers may prompt moderate rebates, slightly lowering net price.

Long-Term (3-5 Years)

• Potential for price reductions driven by:
  • Increased competition if new exon 53 skipping therapies enter the market.
  • Volume-based discounts as diagnosed patient numbers grow.
  • Policy shifts advocating for value-based pricing models.
• Alternatively, pricing could marginally increase if treatment extends survival and broadens indications.

Market Factors Impacting Price

Factor	Effect	Data/Source
Market competition	Pressure to reduce prices	[1], [2]
Expanded patient detection	Increases demand, stabilizing prices	[3]
Payer negotiations	Slight rebates and discounts	[4]
Regulatory policies on orphan drugs	Could limit price increases	[5]

Risks and Opportunities

• Risks: Entry of cheaper generics or biosimilars (unlikely for gene therapies soon), policy shifts toward price controls, patent expirations.
• Opportunities: Expansion into off-label uses, broader payer acceptance, increased enrollment due to advances in genetic testing.

Key Takeaways

• The initial list price of Vyondys 53 is approximately $375,000/year.
• The target patient population in the U.S. is roughly 1,000-1,300 individuals.
• Sales are expected to stabilize in the near term, with potential slight declines due to rebates.
• Price adjustments over the next 3-5 years depend on market entry of competitors, policy changes, and payer negotiations.
• The rare disease nature supports high pricing, but reimbursement pressures could moderate net sales.

FAQs

1. What is the primary indication for NDC 51407-0266?
   Duchenne muscular dystrophy patients with mutations amenable to exon 53 skipping.

2. Are there biosimilars or generics available?
   No, gene-based therapies typically do not have biosimilar alternatives in the near term.

3. What factors influence the net price paid by payers?
   Rebate programs, formulary status, and negotiated discounts.

4. How does Vyondys 53 compare with similar treatments?
   Its list price is comparable to Exondys 51, with a similar target patient profile and reimbursement landscape.

5. What is the outlook for future pricing?
   Expected to remain stable initially, with potential slight decreases or increases based on competition, policy, and market dynamics.

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References

1. U.S. Food and Drug Administration (2020). FDA approvals and orphan drug designations.
2. IQVIA (2022). Pharma market analysis reports.
3. Sarepta Therapeutics (2021). Annual financial report.
4. CMS (2022). Reimbursement and pricing policies.
5. Congressional Budget Office (2021). Policy impact reviews.