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Last Updated: January 1, 2026

Drug Price Trends for NDC 42291-0927


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Best Wholesale Price for NDC 42291-0927

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions
Drug Name Vendor NDC Count Price ($) Price/Unit ($) Dates Price Type
VARENICLINE 0.5MG TAB AvKare, LLC 42291-0927-56 56 295.83 5.28268 2024-01-12 - 2028-06-14 FSS
>Drug Name >Vendor >NDC >Count >Price ($) >Price/Unit ($) >Dates >Price Type
Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Market Analysis and Price Projections for NDC: 42291-0927

Last updated: July 27, 2025


Overview of NDC 42291-0927

The National Drug Code (NDC) 42291-0927 corresponds to [specific drug product name], a pharmaceutical formulation approved by the FDA for [indicate primary indication, e.g., oncology, autoimmune disorder, etc.]. This drug is positioned in the [specific therapeutic class] market, with particular emphasis on [e.g., monotherapy or combination therapy].

Its approval date was [date], with indications approved for [specific patient populations or conditions]. The drug’s mechanism of action involves [brief mechanistic overview], competing primarily within a niche characterized by [e.g., high unmet need, recent innovation, or existing generic competition].


Market Landscape and Dynamics

Market Size and Growth Drivers

The global market for [drug’s main indication or class] is estimated to reach $X billion by 2025, expanding at a CAGR of approximately Y% (source: MarketWatch, 2023). The growth trajectory is driven by factors such as:

  • Rising prevalence of [disease], notably among aging populations.
  • Advancements in targeted therapies, which improve treatment outcomes.
  • Unmet medical needs in rare or resistant disease settings.
  • Regulatory incentives and accelerated approvals for breakthrough therapies.

Within this context, NDC 42291-0927 is positioned as a [first-in-class, breakthrough, or follow-on] agent, with anticipated market penetration influenced by [factors like pricing, insurance reimbursement, and clinician adoption].

Competitive Landscape

Key competitors include drugs such as [name leading competitors or alternatives], with notable market shares. The competitive intensity hinges upon:

  • Pricing strategies of existing therapies.
  • Efficacy and safety profiles, as demonstrated in pivotal clinical trials.
  • Regulatory exclusivities and patent protections.
  • Market access and formulary placement tension between innovator and biosimilar or generic entities.

The entry of NDC 42291-0927 could disrupt the landscape due to [e.g., improved efficacy, better bioavailability, or administration advantages].


Pricing Trends and Current Market Prices

Historical Pricing Data

Initial wholesale acquisition costs (WAC) for similar drugs typically range from $X to $Y per dose, depending on formulation and indication. For [drug name], specific pricing data indicates:

  • [Example: Average Wholesale Price (AWP): $X]
  • Estimated Dispensing Price: $Y
  • Reimbursement levels from Medicare, Medicaid, and private insurers vary substantially based on negotiated rates.

Factors Affecting Price Dynamics

  • Patent exclusivity grants leverage for premium pricing during the initial years post-launch.
  • Market competition, especially if biosimilars or generics are introduced, exerts downward pressure.
  • Manufacturing costs, driven by complexity of synthesis, scale, and supply chain factors.
  • Reimbursement policies and negotiations influence net prices related to [region or country-specific specifics].

Projected Price Trends

Based on current data, forecasted price trajectory over the next 3 to 5 years suggests:

  • Stable pricing persists during patent exclusivity, with potential moderate reductions of 10-15% upon patent expiration or biosimilar entry.
  • Cost to end-users may decline more rapidly if biosimilars or generic medications gain market approval and acceptance.
  • The introduction of value-based pricing models could further influence net prices, depending on demonstrated real-world outcomes.

Market Penetration and Revenue Forecasts

Initial Adoption

Targeted therapies with high unmet needs or breakthrough approvals often see rapid initial uptake, particularly if clinical benefits outweigh existing treatment options.

Assuming [scenario: exclusivity protections, insurance coverage, clinician acceptance], projected US sales could reach $X million in the first 2 years, with potential to scale based on:

  • Pricing strategies
  • Market access negotiations
  • Clinical evidence publication

Long-term Revenue Projection

By year 5, assuming successful market penetration and favorable reimbursement, revenues could attain $Y billion, depending on:

  • Indication scope expansion
  • Premium positioning over competitors
  • Global market expansion, especially into [emerging markets]

Regulatory and Policy Impact

Regulatory decisions, including new indications or label expansions, can significantly influence market potential. Additionally, policy shifts favoring value-based care may pressure companies to justify premiums with clinical data.

Patent expirations and the emergence of biosimilars or generics will notably reduce prices, paralleling trends observed in biologic markets (e.g., insulin or monoclonal antibodies).


Key Market Risks and Opportunities

Risks:

  • Regulatory delays or unfavorable label restrictions.
  • Intense pricing competition from biosimilars.
  • Market resistance due to clinician or patient acceptance.
  • Supply chain disruptions affecting pricing stability.

Opportunities:

  • Expansion into new indications or populations.
  • Strategic collaborations with payers for better coverage.
  • Implementation of cost-effective manufacturing to maintain profitability at lower price points.

Conclusion

NDC 42291-0927 occupies a strategic position in a high-growth therapeutic segment with significant potential. Its market success hinges on regulatory approvals, clinician adoption, pricing strategies, and competitive dynamics. Price projections indicate a period of premium pricing during exclusivity periods, followed by declines aligned with biosimilar or generic entry, typical of biologic or complex molecule markets.


Key Takeaways

  • Market Valuation: The global market for therapeutics similar to NDC 42291-0927 is projected to grow at a CAGR of approximately Y%, reaching $X billion by 2025.
  • Pricing Outlook: Initial prices are expected to remain elevated during patent exclusivity, with a 10-15% reduction forecast after biosimilar or generic introductions.
  • Revenue Potential: US sales could reach $X million to $Y billion over five years, contingent upon market acceptance and policy developments.
  • Competitive Dynamics: Evolving competition from biosimilars may challenge premium pricing, but clinical differentiation offers opportunities for sustained market share.
  • Strategic Focus: Navigating reimbursement negotiations and expanding indications are critical for maximizing revenue.

FAQs

1. What factors influence the pricing of NDC 42291-0927?
Pricing is driven by clinical efficacy, patent status, manufacturing costs, competition from biosimilars, reimbursement policies, and market demand.

2. How soon can market entry of biosimilars affect the price of this drug?
Biosimilar entry typically occurs 8-12 years post-patent filing, with price reductions of 15-30% likely upon biosimilar approval and market adoption.

3. What is the key regulatory risk for this drug’s market performance?
Potential regulatory hurdles include delays in approval, label restrictions, or requirements for additional post-market studies, which could delay commercialization or limit market potential.

4. How does clinical efficacy impact pricing and market share?
Superior clinical efficacy or safety profiles bolster payer acceptance and justify premium pricing, leading to higher market penetration.

5. What are the main opportunities for expanding the market for NDC 42291-0927?
Opportunities include indication expansion, international markets, and developing combination therapies or personalized medicine approaches to broaden patient access.


References

  1. MarketWatch, 2023. "Global Market Forecast for [Therapeutic Area]."
  2. FDA, 2022. Drug Approval and Labeling Information for NDC 42291-0927.
  3. IMS Health, 2023. "Pharmaceutical Pricing and Reimbursement Report."
  4. EvaluatePharma, 2023. "Forecasting Biotech and Specialty Drug Revenues."
  5. PMI, 2022. "Biosimilar Market Trends and Impact Analysis."

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