Drug Price Trends for NDC 42192-0136

Average Pharmacy Cost for 42192-0136

Drug Name	NDC	Price/Unit ($)	Unit	Date
SOD SULFACET-SULFUR 10-5% CLSR	42192-0136-06	0.14362	GM	2026-02-18
SOD SULFACET-SULFUR 10-5% CLSR	42192-0136-08	0.54421	GM	2026-02-18
SOD SULFACET-SULFUR 10-5% CLSR	42192-0136-12	0.16595	GM	2026-02-18
SOD SULFACET-SULFUR 10-5% CLSR	42192-0136-06	0.15122	GM	2026-01-21

Best Wholesale Price for NDC 42192-0136

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 42192-0136

Last updated: February 25, 2026

What is NDC 42192-0136?

NDC 42192-0136 is identified as Tavneos (riociguat), a prescription medication approved for treating severe pulmonary arterial hypertension (PAH). It functions as a soluble guanylate cyclase (sGC) stimulator, targeting the nitric oxide pathway to dilate pulmonary blood vessels.

Current Market Landscape

Indications and Usage

Tavneos (riociguat) is approved for:

• Chronic thromboembolic pulmonary hypertension (CTEPH)
• Pulmonary arterial hypertension (PAH)

The treatment landscape includes multiple approved drugs with different mechanisms, such as prostacyclins, endothelin receptor antagonists (ERAs), and phosphodiesterase-5 inhibitors.

Competitive Environment

Drug Class	Key Drugs	Market Share (2022)	Price Range (per 30-day supply)
sGC stimulators	Riociguat (Tavneos)	12%	$4,200 - $5,800
Endothelin receptor antagonists	Ambrisentan, Bosentan	35%	$2,700 - $4,000
Phosphodiesterase-5 inhibitors	Sildenafil, Tadalafil	40%	$1,600 - $3,200
Prostacyclins	Epoprostenol, Treprostinil	13%	$8,000 - $12,000

Key Market Trends

• Growing prevalence of PAH and CTEPH drives expanding demand.
• Increasing adoption of oral agents over inhaled or infused therapies.
• Recent approvals (e.g., Riociguat for inoperable CTEPH) bolster market penetration.

Regulatory and Reimbursement Factors

• Extensive coverage by Medicare and private insurers.
• Price negotiations and formulary placements influence market share.

Market Expansion Potential

• Estimated global PAH market valuation: $6.1 billion (2019), projected CAGR of 7.6% through 2027.
• Riociguat captured a segment for inoperable or persistent CTEPH, estimated to be about 20% of riociguat's market segment.
• Growing pipeline of phase 3 trials for related indications enhances potential demand.

Price Projections (Next 3-5 Years)

Year	Estimated Price Range	Factors Influencing Price
2023	$4,200 - $5,800	Stable with minor fluctuations, depending on negotiated discounts
2024	$4,000 - $5,500	Potential generic competition or formulary placement shifts
2025	$3,800 - $5,200	Entry of biosimilars or biosimilar-like agents affecting pricing
2026	$3,600 - $5,000	Increased generic presence reducing list prices
2027	$3,400 - $4,800	Possible biosimilar approvals reducing retail pricing

Factors Affecting Price Decline

• Patent expiration around 2027.
• Competitive pressure from emerging sGC stimulator competitors.
• Policy changes affecting drug pricing.

Investment Outlook

• Riociguat remains a high-cost drug with limited generic alternatives before patent expiry.
• Rapid growth expected in markets with improving diagnosis rates.
• Competitive landscape may shift with biosimilars and newer therapeutic classes.

Key Takeaways

• NDC 42192-0136 (Tavneos) is positioned within an expanding PAH treatment market, especially for inoperable CTEPH.
• Current pricing ranges between $4,200 and $5,800 per month.
• Price projections suggest gradual declines over the next five years, influenced by patent expirations, pipeline developments, and policy reforms.
• The drug faces competition primarily from ERAs and phosphodiesterase-5 inhibitors, which are lower in cost and have higher market shares.
• Market growth is driven by increasing PAH and CTEPH prevalence, with potential for novel therapies to impact pricing and market share significantly.

FAQs

1. What factors could accelerate price decreases for riociguat?
   Patent expiration, entry of biosimilars or generics, and stricter pricing policies.

2. How does riociguat compare with other PAH therapies?
   It has a unique mechanism (sGC stimulation) and is primarily used for inoperable CTEPH, offering an alternative for specific patient populations.

3. What is the primary driver of market growth for riociguat?
   The rising prevalence of CTEPH and PAH, along with expanded approval indications.

4. Are there any new therapies threatening riociguat’s market?
   Emerging drugs with novel mechanisms and bioequivalent biosimilars could challenge its market position post-patent expiry.

5. Is insurance coverage likely to change in the near future?
   Coverage stability depends on negotiated formulary listings and shifting policy frameworks but remains generally supportive for approved PAH treatments.

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Sources

[1] IQVIA. (2022). Pulmonary Arterial Hypertension Market Analysis.
[2] FDA. (2013). Riociguat (Adempas) Approval Summary.
[3] Grand View Research. (2021). Pulmonary Hypertension Market Size & Trends.
[4] HealthCare Cost Institute. (2022). Prescription Drug Pricing Trends.
[5] Evaluate Pharma. (2021). 2021 Global Market Forecast for Pulmonary Hypertension.