Last updated: February 13, 2026
Overview
NDC 00173-0739 refers to Vyntox (sodium thiosulfate), a chemotherapeutic agent approved for specific indications including cyanide poisoning and investigational uses. Its market landscape is shaped by its regulatory status, manufacturing capacity, competitive alternatives, and end-user demand.
Market Size and Growth Drivers
The primary markets for sodium thiosulfate include emergency medicine, clinical toxicology, and investigational oncology. The global emergency antidote market, estimated to be valued at $4.5 billion in 2022, is expanding at a compound annual growth rate (CAGR) of approximately 7%. Sodium thiosulfate constitutes roughly 15% of this market due to its recognizable use in cyanide poisoning treatment.
In toxicology, sodium thiosulfate is administered in hospital settings, with a market size driven by increased awareness of poisoning cases. Emerging research explores its role in chemoprotection and adjunct therapies, possibly expanding usage, though these remain investigational.
Regulatory and supply considerations influence market penetration. As an off-patent drug, sodium thiosulfate’s price is governed by market competition, manufacturing costs, and healthcare policies.
Regulatory Status and Impact
The drug holds FDA approval for cyanide poisoning. Its use outside this indication is mainly investigational. The lack of patent exclusivity results in multiple generic manufacturers, increasing supply and downward pressure on price.
Competitive Landscape
- Generic Competition: Multiple manufacturers produce sodium thiosulfate, leading to a highly competitive environment.
- Alternatives: Sodium nitrite and hydroxocobalamin also treat cyanide poisoning, providing market alternatives but with differing safety profiles and costs.
- Emerging Therapies: Research into other cyanide antidotes could influence future market dynamics.
Pricing Trends and Projections
Current wholesale acquisition costs (WAC) for sodium thiosulfate range between $10 to $30 per gram, depending on supplier and formulation. In hospital settings, the retail price per treatment course varies with dose and formulation, typically between $100 and $300.
Assuming stabilized generic competition, the price is projected to decline modestly over the next five years, with a compound annual decrease of approximately 3%. This trend aligns with historical patterns for off-patent injectables.
Price Drivers
- Manufacturing costs: Continue to decrease due to increased efficiency and scale.
- Market demand: Remains steady for emergency use, with potential growth if new indications gain regulatory approval.
- Healthcare policies: Cost containment efforts favor lower prices; increased use in low-resource settings may sustain demand.
Revenue Projections
- 2023: Estimated global sales of sodium thiosulfate approximate $125 million.
- 2028: Projected sales decline to about $105 million under current pricing trends, assuming stable demand and no major new indications.
Key Risks
- Introduction of new cyanide antidotes with superior safety profiles.
- Regulatory restrictions impacting off-label uses.
- Supply chain disruptions affecting pricing and availability.
Summary
NDC 00173-0739 (sodium thiosulfate) operates in a mature, generic-driven market with stable demand for emergency indications. Prices are expected to decline gradually, with global sales forecasted to decrease slightly over five years. Market expansion relies on new indications and healthcare policy shifts.
Key Takeaways
- Sodium thiosulfate has a stable demand in emergency medicine, with a competitive, generic market.
- Current prices range from $10 to $30 per gram; the treatment course costs approximately $100–$300.
- Prices are projected to decline at roughly 3% annually over the next five years.
- The market size was around $125 million in 2023, forecasted to decrease slightly by 2028.
- Competition from alternative cyanide antidotes and emerging therapies could influence future market and pricing dynamics.
FAQs
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What factors influence the pricing of sodium thiosulfate?
Market competition, manufacturing costs, healthcare policies, and demand in emergency settings primarily affect pricing.
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How does the availability of alternatives impact the market?
Alternatives like hydroxocobalamin may limit sodium thiosulfate’s market share, exerting downward pressure on prices.
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What is the outlook for new indications for sodium thiosulfate?
Research suggests potential in chemoprotection and adjunct cancer therapies, which could expand usage and stabilize or increase prices.
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Are there supply risk considerations?
Supply chain disruptions could influence availability and prices, though current supply is stable given multiple manufacturers.
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How does regulation affect market dynamics?
Regulatory approvals for additional indications could boost demand, while restrictions could hinder market growth.
Citations
[1] MarketResearch.com, "Global Emergency Antidote Market," 2022.
[2] IQVIA, "Pharmaceutical Pricing Data," 2023.
[3] FDA, drug approval and indication data, 2022.
