Last updated: February 20, 2026
What is NDC 00037-0442?
NDC 00037-0442 refers to a specific commercial drug product listed in the National Drug Code Directory. According to available data, this code corresponds to Cacit containing calcium carbonate, magnesium hydroxide, and simethicone.
The drug is primarily used as an antacid to treat heartburn, indigestion, and related gastrointestinal conditions. It is available over-the-counter in multiple formulations, often in chewable tablet form.
Current Market Landscape
Market Size and Demand
The antacid market in the U.S. is projected to reach approximately $1.5 billion by 2025, growing at a compound annual growth rate (CAGR) of about 4% from 2020 to 2025 [1].
Key factors influencing demand include:
- Increasing prevalence of gastroesophageal reflux disease (GERD) and indigestion
- Aging population
- Consumer preference for over-the-counter medications
Competitor Analysis
Major competitors in oral antacids include:
- Calcium carbonate-based products (e.g., Tums, Rolaids)
- Magnesium hydroxide and aluminum hydroxide formulations (e.g., Mylanta, Maalox)
- Combination products that include simethicone for gas relief
The presence of combination medications such as NDC 00037-0442 reflects efforts to target multifaceted gastrointestinal issues with a single formulation.
Regulatory Status
The drug is marketed as an OTC product, with generics making up a significant share of the market. The FDA's OTC monograph system governs product formulations, allowing multiple manufacturers to produce similar formulations without individual approval.
Production & Distribution
Major distributors include national pharmacy chains, supermarkets, and online pharmacies. Distribution channels shifted toward online sales during the COVID-19 pandemic, contributing to increased sales volume.
Price Trends and Projections
Current Pricing
- Brand-name equivalents (e.g., Tums): retail price approximately $6–$8 for a bottle of 60 to 100 chewable tablets.
- Generic formulations: retail prices are approximately $3–$5 for comparable quantities [2].
Bulk purchasing prices for pharmacies range from $0.05 to $0.10 per tablet, depending on purchase volume and supplier agreements.
Future Price Projections
-
Market Competition Dynamics
The OTC antacid market experiences intense price competition due to commoditization. With multiple generics, prices are unlikely to rise significantly barring supply constraints or formulations with novel benefits.
-
Potential Price Adjustments
Innovative formulations or combination products that demonstrate superior efficacy or reduced side effects could command higher prices. However, existing data suggest these adjustments are minimal for standard formulations like NDC 00037-0442.
-
Impact of Manufacturing Costs
Raw material prices for calcium carbonate and magnesium hydroxide are relatively stable. Slight increases in manufacturing costs may elevate consumer prices marginally, but the effect remains limited.
-
Regulatory Changes & Patent Status
Since the drug is marketed as an OTC with multiple generic manufacturers, patent expiration impedes pricing power. Any regulatory shifts favoring new delivery systems could influence future prices.
Outlook Summary
| Factor |
Effect on Price |
| Market saturation |
Stabilizes or decreases prices |
| Introduction of premium formulations |
Could raise prices temporarily |
| Raw material cost fluctuations |
Slight upward pressure |
| Regulatory innovations |
Potential for price adjustments |
The outlook suggests that average retail prices will remain within a narrow band over the next 3–5 years, with minimal upward trend absent significant product innovations.
Key Market Opportunities
- Development of formulations combining antacid effects with probiotics or other GI therapies
- Expansion of OTC availability through online channels
- Potential for private-label brands offering lower prices
Key Challenges
- Price erosion due to generic competition
- Regulatory barriers for new formulations
- Consumer preference for established brands with high trust
Summary of Data Points
| Data Point |
Value / Note |
| U.S. OTC antacid market size (2025 forecast) |
$1.5 billion |
| Average retail price (generic) |
$3–$5 per bottle |
| Price per tablet (bulk) |
$0.05–$0.10 |
| CAGR of market demand |
4% (2020-2025) |
| Major competitors |
Tums, Rolaids, Mylanta |
| Market share of generics |
>75% |
Key Takeaways
- NDC 00037-0442 belongs to a competitive OTC antacid segment with stable price trends.
- The market benefits from increasing demand but faces price pressure from high generic penetration.
- Future price increases are unlikely unless product innovation or regulatory shifts occur.
- Cost stability of key raw materials supports consistent pricing.
- Expansion into online sales channels is a primary growth avenue.
FAQs
1. What factors influence the pricing of OTC antacids like NDC 00037-0442?
Market competition, raw material costs, regulatory environment, and consumer demand impact retail and wholesale prices.
2. How does generic competition affect pricing in this market?
High generic availability caps price increases and encourages price competition, leading to stable or declining retail prices.
3. Are there opportunities for premium pricing?
Yes, if new formulations or added benefits (e.g., probiotics, dual-action) are introduced, prices could increase temporarily.
4. What demographic trends could expand market size?
Aging populations and rising GERD prevalence increase demand for antacids in coming years.
5. How might regulatory changes impact future prices?
Innovations approved under new OTC monographs or modifications to existing regulations could influence pricing strategies.
References
- MarketWatch. (2021). Antacid Market Size & Growth. Retrieved from source.
- GoodRx. (2023). OTC Antacid Price Comparison. Retrieved from source.
