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Drug Price Trends for PENTAZOCINE-NALOXONE TABLET
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Average Pharmacy Cost for PENTAZOCINE-NALOXONE TABLET
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| PENTAZOCINE-NALOXONE TABLET | 00591-0395-01 | 1.69431 | EACH | 2024-12-18 |
| PENTAZOCINE-NALOXONE TABLET | 43386-0680-01 | 1.69431 | EACH | 2024-12-18 |
| PENTAZOCINE-NALOXONE TABLET | 00591-0395-01 | 1.68969 | EACH | 2024-11-20 |
| PENTAZOCINE-NALOXONE TABLET | 43386-0680-01 | 1.68969 | EACH | 2024-11-20 |
| PENTAZOCINE-NALOXONE TABLET | 43386-0680-01 | 2.03351 | EACH | 2024-10-23 |
| PENTAZOCINE-NALOXONE TABLET | 00591-0395-01 | 2.03351 | EACH | 2024-10-23 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Market Analysis and Price Projections for Pentazocine-Naloxone Tablets
Introduction
Pentazocine-naloxone tablets, known by the trade name Talwin Nx, are a formulation designed to manage severe pain while mitigating the risk of opioid abuse. This analysis will delve into the market dynamics, usage patterns, and price projections for this medication.
Market Dynamics
Growing Demand for Naloxone
The naloxone market, which includes formulations like pentazocine-naloxone, is expected to grow significantly due to the increasing prevalence of opioid overdose cases globally. The market is projected to increase from USD 1,341.5 million in 2024 to USD 2,683.9 million by 2031, with a compound annual growth rate (CAGR) of 10.4%[3].
Government Policies and Public Awareness
Favorable government policies and public awareness campaigns aimed at increasing the availability of naloxone are driving market growth. Many states and municipalities now recommend or require naloxone to be co-prescribed with opioid prescriptions, which has led to an increase in demand[3].
Usage Patterns and Abuse Reduction
Historical Context
The introduction of Talwin Nx in 1983 marked a significant shift in the management of pentazocine abuse. By adding 0.5 mg of naloxone hydrochloride to the tablet formulation, the product became pharmacologically inactive when taken orally but active if administered parenterally, thus deterring injection abuse. This reformulation led to a substantial reduction in emergency room and medical examiner mentions related to pentazocine abuse, with decreases of 70% and 71%, respectively[1][4].
Current Usage
Pentazocine-naloxone tablets are indicated for the management of severe pain that requires an opioid analgesic and for which alternative treatments are inadequate. Despite the risks of addiction, abuse, and misuse associated with opioids, these tablets remain a crucial option for patients who have not responded to other treatments[2].
Pharmacological Profile
Pentazocine
Pentazocine is a mixed agonist-antagonist at opioid receptors, acting as a partial agonist at the mu opioid receptor and an agonist at the kappa opioid receptor. It produces respiratory depression, miosis, and sedative effects[2].
Naloxone
Naloxone is an opioid antagonist that is pharmacologically inactive at 0.5 mg when taken orally but becomes active if administered parenterally, thereby neutralizing the effects of pentazocine if the product is misused by injection[2].
Price Projections
Market Trends
The price of pentazocine-naloxone tablets can be influenced by several factors, including the growing demand for naloxone, government policies, and the overall opioid market dynamics. As the naloxone market expands, prices may stabilize or decrease due to increased competition and government initiatives to make naloxone more accessible[3].
Current Pricing
The current prices for pentazocine-naloxone tablets vary based on location, pharmacy, and insurance coverage. However, with many private and public healthcare plans providing coverage for naloxone, the affordability of these tablets is expected to remain relatively stable[5].
Future Outlook
Increasing Accessibility
Government and healthcare initiatives aimed at increasing public awareness and accessibility of naloxone are expected to continue, which may lead to more competitive pricing in the market. As more states and municipalities mandate the co-prescription of naloxone with opioid prescriptions, the demand and subsequently the production costs could influence pricing[3].
Technological and Formulation Advancements
Advancements in drug formulation and delivery systems could also impact the pricing of pentazocine-naloxone tablets. New technologies that enhance the efficacy or reduce the abuse potential of these medications could lead to premium pricing or cost savings depending on the innovation[2].
Key Takeaways
- The pentazocine-naloxone tablet market is driven by the growing need for opioid abuse mitigation and increasing government support.
- The addition of naloxone to pentazocine has significantly reduced abuse rates.
- Prices are expected to be influenced by market growth, government policies, and technological advancements.
- The overall trend suggests stable to decreasing prices due to increased accessibility and competition.
FAQs
Q: What is the primary purpose of adding naloxone to pentazocine tablets? A: The primary purpose is to deter abuse by making the product pharmacologically inactive if injected, thus preventing the narcotic effects of pentazocine[1][2].
Q: How has the introduction of Talwin Nx impacted pentazocine abuse? A: The introduction of Talwin Nx has led to a significant reduction in emergency room and medical examiner mentions related to pentazocine abuse, with decreases of 70% and 71%, respectively[1][4].
Q: What are the indications for using pentazocine-naloxone tablets? A: These tablets are indicated for the management of severe pain that requires an opioid analgesic and for which alternative treatments are inadequate[2].
Q: How does the naloxone component affect the pharmacological activity of pentazocine? A: Naloxone is inactive orally but active if administered parenterally, thereby neutralizing the effects of pentazocine if the product is misused by injection[2].
Q: What are the projected market trends for naloxone and its formulations? A: The naloxone market is expected to grow from USD 1,341.5 million in 2024 to USD 2,683.9 million by 2031, with a CAGR of 10.4%[3].
Sources
- CDC Stacks: Naloxone on the Use and Abuse of Pentazocine.
- Drugs.com: Pentazocine Naloxone: Package Insert / Prescribing Info.
- Coherent Market Insights: Naloxone Market Size & Share Analysis - Industry Research Report.
- PubMed: The impact of the addition of naloxone on the use and abuse of pentazocine.
- Drugs.com: Naloxone/pentazocine Prices, Coupons, Copay Cards & Patient Assistance Programs.
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