Drug Price Trends for LEVONORGESTREL-ETH ESTRAD

Average Pharmacy Cost for LEVONORGESTREL-ETH ESTRAD

These are average pharmacy acquisition costs (net of discounts) from a US national survey

Drug Name	NDC	Price/Unit ($)	Unit	Date
LEVONORGESTREL-ETH ESTRAD 0.15 MG-0.03 MG TABLET	68180-0843-11	0.18725	EACH	2025-06-18
LEVONORGESTREL-ETH ESTRAD 0.15 MG-0.03 MG TABLET	68462-0672-91	0.18725	EACH	2025-06-18
LEVONORGESTREL-ETH ESTRAD 0.15 MG-0.03 MG TABLET	68462-0672-95	0.18725	EACH	2025-06-18
LEVONORGESTREL-ETH ESTRAD 0.15 MG-0.03 MG TABLET	68180-0843-13	0.18725	EACH	2025-06-18
LEVONORGESTREL-ETH ESTRADIOL-FE BISGLYC 0.1-0.02-36.5 MG TAB	42192-0623-28	5.50122	EACH	2025-06-18

Market Analysis and Price Projections for Levonorgestrel-Ethynyl Estradiol

Last updated: January 4, 2025

Introduction

Levonorgestrel and ethinyl estradiol, commonly used in combination oral contraceptives (COCs), are pivotal in the reproductive health market. This analysis delves into the market dynamics, pricing, and future projections for these medications.

Market Size and Forecast

The global market for ethinyl estradiol and levonorgestrel is experiencing significant growth. From 2023 to 2031, the market is expected to expand substantially, driven by increasing demand for effective contraceptive methods and the broader acceptance of extended-cycle regimens[3].

• Growth Rate: The market is projected to grow at a notable rate, with the levonorgestrel API market specifically expected to grow at a CAGR of 4.13% from 2024 to 2031[4].
• Geographical Segmentation: The North American region holds a significant revenue share, but other regions such as Europe, Asia-Pacific, and South America are also contributing to the market's growth[3].

Pricing and Cost Analysis

The pricing of levonorgestrel and ethinyl estradiol combination tablets varies based on the dosage regimen, brand, and geographical location.

• Extended Cycle Regimens: For example, the cost for an extended cycle regimen (30 mcg-0.15 mg) can range from $134 to $170 for a supply of 273 tablets, depending on the pharmacy and any discounts applied[2][5].
• Generic Versions: Generic versions of these medications, such as those for Vienva (20 mcg-100 mcg), are available at lower prices, starting from around $37 for a supply of 84 tablets[5].
• Discount Programs: Various discount programs and copay cards can further reduce the cost, making these medications more accessible to a wider population[2][5].

Product Variations and Dosage Regimens

The market offers several dosage regimens, each with its own pricing structure:

• Quadriphasic Extended Cycle: This regimen, such as Quartette, involves a gradual increase in ethinyl estradiol doses (20 mcg, 25 mcg, 30 mcg) combined with a constant levonorgestrel dose (150 mcg), followed by a 7-day period of 10 mcg ethinyl estradiol alone. This regimen is designed to reduce breakthrough bleeding and spotting[1].
• Triphasic and Biphasic Regimens: Other regimens include triphasic and biphasic extended cycles, each with different dosing schedules and corresponding price points[2].

Market Drivers and Restraints

Several factors influence the market dynamics:

• Drivers: Increasing awareness and acceptance of extended-cycle contraceptives, growing demand for effective birth control methods, and advancements in pharmaceutical technology are driving the market forward[3].
• Restraints: Safety concerns associated with COCs, such as the risk of thromboembolic events, and regulatory hurdles can act as restraints. However, these risks are well-managed through proper medical supervision and patient education[1].

Consumer Behavior and Access

Consumer behavior plays a crucial role in the market:

• Affordability: The availability of generic versions and discount programs has made these medications more affordable, increasing their accessibility to a broader population[2][5].
• Health Insurance: Many patients rely on health insurance to cover the cost of these medications. Programs like the Patient Access Network Foundation (PAN) also provide assistance to eligible patients[5].

Key Players and Market Competition

The market is competitive, with several key players:

• Brand Names: Vienva, Aviane, Lutera, and Kurvelo are some of the well-known brand names in the market[2].
• Generic Manufacturers: The presence of multiple generic manufacturers helps in keeping prices competitive and ensures a steady supply of these medications[5].

Future Projections

Given the current trends and market analysis, here are some future projections:

• Continued Growth: The market is expected to continue its upward trend, driven by increasing demand and the introduction of new dosage regimens[3].
• Price Stability: While prices may fluctuate based on market dynamics, the overall trend suggests that prices will remain relatively stable, with discounts and generic options keeping costs manageable for consumers[2][5].

Key Takeaways

• The global market for ethinyl estradiol and levonorgestrel is growing rapidly.
• Various dosage regimens, including quadriphasic, triphasic, and biphasic extended cycles, are available.
• Pricing varies but is generally affordable, especially with generic options and discount programs.
• Market drivers include increasing demand for effective birth control and advancements in pharmaceutical technology.
• Consumer behavior and access to health insurance play significant roles in the market.

FAQs

What are the common dosage regimens for levonorgestrel and ethinyl estradiol?

Common dosage regimens include quadriphasic, triphasic, and biphasic extended cycles, with varying doses of ethinyl estradiol combined with a constant or varying dose of levonorgestrel[1][2].

How much does a typical supply of levonorgestrel and ethinyl estradiol cost?

The cost can range from $37 for a supply of 84 tablets (generic versions) to around $134 for a supply of 273 tablets (extended cycle regimens), depending on the pharmacy and any discounts applied[2][5].

What are the key drivers of the ethinyl estradiol and levonorgestrel market?

Key drivers include increasing awareness and acceptance of extended-cycle contraceptives, growing demand for effective birth control methods, and advancements in pharmaceutical technology[3].

Are there any safety concerns associated with levonorgestrel and ethinyl estradiol?

Yes, there are safety concerns such as the risk of thromboembolic events, but these risks are well-managed through proper medical supervision and patient education[1].

What discount programs are available for levonorgestrel and ethinyl estradiol?

Various discount programs and copay cards, such as the Drugs.com discount card and the Patient Access Network Foundation (PAN), can help reduce the cost of these medications[2][5].

Sources

1. FDA Clinical Review-Draft: NDA 204061 Quartette (levonorgestrel/ethinyl estradiol)[1].
2. Drugs.com: Ethinyl estradiol/levonorgestrel Prices, Coupons, Copay Cards & Patient Assistance[2].
3. Market Research Intellect: Global Ethinyl Estradiol And Levonorgestrel Market Size And Forecast[3].
4. DrugPatentWatch: Drug prices and trends for LEVONOR-ETH ESTRA[4].
5. Drugs.com: Vienva Prices, Coupons, Copay Cards & Patient Assistance[5].