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Last Updated: February 16, 2025

Drug Price Trends for LEVONOR-ETH ESTRA


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Drug Price Trends for LEVONOR-ETH ESTRA

Average Pharmacy Cost for LEVONOR-ETH ESTRA

These are average pharmacy acquisition costs (net of discounts) from a US national survey
Drug Name NDC Price/Unit ($) Unit Date
LEVONOR-ETH ESTRA 0.09-0.02 MG 68462-0637-84 0.90766 EACH 2025-01-22
LEVONOR-ETH ESTRAD 0.1-0.02 MG 00378-7287-85 0.14009 EACH 2025-01-22
LEVONOR-ETH ESTRAD 0.1-0.02 MG 31722-0944-32 0.14009 EACH 2025-01-22
LEVONOR-ETH ESTRAD 0.1-0.02 MG 00378-7287-53 0.14009 EACH 2025-01-22
LEVONOR-ETH ESTRAD TRIPHASIC 68180-0857-73 0.29784 EACH 2025-01-22
>Drug Name >NDC >Price/Unit ($) >Unit >Date

Market Analysis and Price Projections for Levonorgestrel and Ethinyl Estradiol

Introduction

Levonorgestrel and ethinyl estradiol, a combination of a progestin and an estrogen, is widely used in oral contraceptives to prevent pregnancy. This market analysis will delve into the current market dynamics, price projections, and key factors influencing the demand and supply of this drug.

Market Size and Growth

The levonorgestrel API market, a crucial component of these contraceptives, was valued at USD 52.01 million in 2023 and is projected to reach USD 71.37 million by 2031, growing at a Compound Annual Growth Rate (CAGR) of 4.13% during the forecast period of 2024-2031[3].

Market Segmentation

The levonorgestrel API market is segmented based on type and application. The short-acting contraceptive API segment is the major contributor, driven by the widespread use of oral contraceptive pills and injectables. By application, the market includes levonorgestrel tablets, mixture products, and hormone-releasing IUDs, with the latter segment expected to witness rapid growth due to its additional benefits such as alleviating heavy or painful periods[3].

Regional Market

The North American region holds a significant revenue share in the levonorgestrel API market, attributed to a robust healthcare system and rising healthcare costs. The Asia Pacific region is also projected to grow rapidly due to a large female population, stringent policies for contraceptive payments, and fertility rates[3].

Key Players

Major players in the levonorgestrel API market include Bayer HealthCare, Qinhuangdao Zizhu Pharmaceutical, Yangzhou Pharmaceutical, Lupin, Hubei Gedian Humanwell, and others. These companies play a crucial role in meeting the global demand for levonorgestrel APIs[3].

Pricing and Cost

The cost of levonorgestrel and ethinyl estradiol tablets varies based on the formulation and quantity. For example, the extended-cycle formulation (30 mcg-0.15 mg) can cost around $134 for a supply of 273 tablets, depending on the pharmacy and any available discounts or coupons[2].

Price Breakdown

  • Extended Cycle 30 mcg-0.15 mg: Around $134 for 273 tablets[2].
  • Low Dose Biphasic Extended Cycle: From $311.63 for 182 tablets[2].
  • Quadriphasic Extended Cycle: From $189.35 for 91 tablets[2].

Discounts and Patient Assistance

Several discount programs and coupons are available to reduce the cost of levonorgestrel and ethinyl estradiol tablets. For instance, the Drugs.com Discount Card and the BuzzRx discount coupon can save consumers up to 80% on the retail price[2][5].

Clinical Trials and Efficacy

Clinical trials have demonstrated the efficacy and safety of levonorgestrel and ethinyl estradiol in extended-cycle regimens. For example, the Seasonale study showed that extended-cycle use can decrease the number of menses a woman experiences per year, with acceptable cycle control and patient satisfaction[4].

Contraindications and Safety

It is important to note that levonorgestrel and ethinyl estradiol tablets are contraindicated in certain conditions, such as a high risk of arterial or venous thrombotic diseases, undiagnosed abnormal uterine bleeding, breast cancer, and liver tumors or liver disease. Smoking in women over 35 years old also increases the risk of serious cardiovascular events[1].

Market Challenges

The market growth is hampered by several factors, including the high cost of safety and health criteria for levonorgestrel APIs, potential issues with intermittency and reliability in certain solutions, and the significant upfront expenditure required for large-scale applications. The COVID-19 pandemic has also caused supply chain disruptions, affecting the sales of API commodities[3].

Future Outlook

The demand for levonorgestrel and ethinyl estradiol is expected to remain strong due to their efficacy in preventing pregnancy and other benefits such as reducing the frequency of menstrual cycles. However, the market will need to address the challenges related to cost, safety, and supply chain disruptions to sustain growth.

Key Takeaways

  • The levonorgestrel API market is projected to grow at a CAGR of 4.13% from 2024 to 2031.
  • The North American region holds a significant revenue share, with the Asia Pacific region expected to grow rapidly.
  • Short-acting contraceptive APIs are the major contributors to the market.
  • Discounts and patient assistance programs can significantly reduce the cost of the medication.
  • Clinical trials have demonstrated the efficacy and safety of extended-cycle regimens.

FAQs

What is the primary use of levonorgestrel and ethinyl estradiol tablets?

Levonorgestrel and ethinyl estradiol tablets are primarily used for preventing pregnancy in females of reproductive potential.

What are the contraindications for levonorgestrel and ethinyl estradiol tablets?

These tablets are contraindicated in women with a high risk of arterial or venous thrombotic diseases, undiagnosed abnormal uterine bleeding, breast cancer, liver tumors or liver disease, and in women over 35 years old who smoke.

How much do levonorgestrel and ethinyl estradiol tablets typically cost?

The cost can vary, but for an extended-cycle formulation (30 mcg-0.15 mg), it can be around $134 for a supply of 273 tablets.

Are there any discount programs available for levonorgestrel and ethinyl estradiol tablets?

Yes, several discount programs and coupons, such as the Drugs.com Discount Card and the BuzzRx discount coupon, can save consumers up to 80% on the retail price.

What are the potential side effects and risks associated with levonorgestrel and ethinyl estradiol tablets?

Potential side effects include spotting, breakthrough bleeding, and increased risk of serious cardiovascular events, especially in women over 35 years old who smoke.

Sources

  1. DailyMed: LEVONORGESTREL AND ETHINYL ESTRADIOL ... - DailyMed
  2. Drugs.com: Ethinyl estradiol/levonorgestrel Prices, Coupons, Copay Cards & Patient Assistance
  3. InsightAce Analytic: Levonorgestrel API Market - InsightAce Analytic
  4. Cleveland Clinic MedEd: Seasonale® (levonorgestrel 0.15 mg/ethinyl estradiol 0.03 mg ...
  5. BuzzRx: Levonorgestrel-Eth Estradiol Coupon - Discounts up to 80% - BuzzRx

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