Drug Price Trends for GLYBURID-METFORMIN

Average Pharmacy Cost for GLYBURID-METFORMIN

These are average pharmacy acquisition costs (net of discounts) from a US national survey

Drug Name	NDC	Price/Unit ($)	Unit	Date
GLYBURID-METFORMIN 1.25-250 MG	65862-0080-01	0.03350	EACH	2024-12-18
GLYBURID-METFORMIN 1.25-250 MG	57237-0023-01	0.03350	EACH	2024-12-18
GLYBURID-METFORMIN 1.25-250 MG	65862-0080-05	0.03350	EACH	2024-12-18

Market Analysis and Price Projections for Glyburide-Metformin

Introduction to Glyburide-Metformin

Glyburide-metformin is a combination medication used to treat type 2 diabetes. It combines the sulfonylurea glyburide and the biguanide metformin, which work synergistically to improve glycemic control. Here, we will delve into the market analysis and price projections for this crucial antidiabetic medication.

Efficacy and Clinical Benefits

Studies have shown that initial treatment with glyburide-metformin tablets provides superior glycemic control compared to monotherapy with either glyburide or metformin alone. A clinical trial involving 486 patients demonstrated that glyburide-metformin tablets resulted in a significant mean reduction in A1C levels from baseline, outperforming both metformin and glyburide monotherapies[1].

Market Size and Growth

The global market for glyburide and metformin hydrochloride is experiencing significant growth. Recent reports indicate that the market has witnessed a substantial surge in recent years and is projected to continue expanding from 2023 to 2031. The market size is anticipated to grow, driven by increasing demand for effective antidiabetic medications, particularly in regions with high prevalence rates of type 2 diabetes[3].

Market Segmentation

The glyburide and metformin hydrochloride market is segmented based on type (tablets, capsules), application (hospitals, clinics, others), and geographical regions (North America, Europe, Asia-Pacific, South America, and Middle-East and Africa). This segmentation helps in understanding the diverse trends and key factors influencing the market across different sectors and regions[3].

Pricing and Cost Analysis

The cost of glyburide-metformin varies depending on the dosage and the pharmacy. Here are some price points for different dosages:

• 1.25 mg-250 mg: The cost for 100 tablets can range from $71.52 to $319.60 for 500 tablets[2].
• 2.5 mg-500 mg: Prices start from $35.25 for 100 tablets and $138.23 for 500 tablets[2].
• 5 mg-500 mg: This dosage can cost between $24.49 and $41.21 for 100 tablets, and $168.04 for 500 tablets[2].

For comparison, the brand-name version, Glucovance (2.5 mg-500 mg), costs around $144 for a supply of 100 tablets, although generic versions are significantly cheaper, starting from $24.80 for 30 tablets[5].

Market Dynamics

Drivers

• Increasing Prevalence of Type 2 Diabetes: The rising global incidence of type 2 diabetes drives the demand for effective antidiabetic medications like glyburide-metformin.
• Efficacy and Safety: The superior glycemic control and lower doses required compared to monotherapies make glyburide-metformin a preferred choice among healthcare providers[1].

Restraints

• Side Effects and Contraindications: Like all medications, glyburide-metformin has potential side effects and contraindications, which can limit its use in certain patient populations.
• Generic Competition: The availability of generic versions can reduce the market share of brand-name products, affecting pricing and revenue[5].

Opportunities

• Emerging Markets: Growing healthcare infrastructure and increasing awareness about diabetes management in emerging markets present significant opportunities for growth.
• Combination Therapies: The trend towards combination therapies for better disease management is likely to boost the demand for glyburide-metformin[3].

Challenges

• Regulatory Hurdles: Strict regulatory environments can impact the approval and marketing of new formulations or dosages.
• Economic Factors: Economic downturns or changes in healthcare policies can affect the affordability and accessibility of the medication[3].

Price Projections

The global market for glyburide and metformin hydrochloride is expected to continue its upward trajectory, although the overall market for metformin drugs is forecasted to decline slightly from $3784 million in 2023 to $2519.3 million by 2030, with a CAGR of -5.6% during the forecast period[4].

However, the combination therapy of glyburide-metformin is likely to maintain its market share due to its clinical benefits and cost-effectiveness. Prices are expected to remain competitive, with generic versions continuing to offer affordable alternatives to brand-name products.

Key Players

The market for glyburide-metformin includes several key players such as Novartis, Apotex, Viatris, Mallinckrodt, Teva Pharmaceuticals, and others. These companies play a crucial role in manufacturing, marketing, and distributing the medication globally[4].

Conclusion

Glyburide-metformin remains a vital medication in the management of type 2 diabetes, offering superior glycemic control and cost-effectiveness. The market is poised for continued growth, driven by increasing demand and the expanding healthcare infrastructure in emerging markets. However, it must navigate challenges such as regulatory hurdles and economic factors.

Key Takeaways

• Superior Glycemic Control: Glyburide-metformin provides better glycemic control compared to monotherapies.
• Cost-Effectiveness: Generic versions of glyburide-metformin offer significant cost savings.
• Market Growth: The global market is expected to grow, driven by increasing demand and emerging markets.
• Challenges: Regulatory and economic factors can impact the market.

FAQs

1. What is the primary use of glyburide-metformin?

   • Glyburide-metformin is used to treat type 2 diabetes by improving glycemic control.

2. How does glyburide-metformin compare to monotherapies?

   • Glyburide-metformin provides superior glycemic control and requires lower doses compared to glyburide or metformin monotherapies[1].

3. What are the typical prices for glyburide-metformin?

   • Prices vary by dosage but generally range from $24 to $144 for a supply of 100 tablets, depending on the pharmacy and whether a generic or brand-name version is used[2][5].

4. Which companies are key players in the glyburide-metformin market?

   • Key players include Novartis, Apotex, Viatris, Mallinckrodt, and Teva Pharmaceuticals, among others[4].

5. What are the projected market trends for glyburide-metformin?

   • The market is expected to grow, driven by increasing demand and emerging markets, although the overall metformin market may see a slight decline[3][4].

Sources

1. Efficacy of Glyburide/Metformin Tablets Compared with Initial Monotherapy in Type 2 Diabetes - Journal of Clinical Endocrinology and Metabolism[1].
2. Glyburide/metformin Prices, Coupons, Copay Cards & Patient Assistance - Drugs.com[2].
3. Global Glyburide And Metformin Hydrochloride Market Size, Scope, and Forecast - Market Research Intellect[3].
4. Metformin Drugs - Global Market Share and Ranking, Overall Sales - Valuates Reports[4].
5. Glucovance Prices, Coupons, Copay Cards & Patient Assistance - Drugs.com[5].