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Drug Price Trends for COMPLERA TABLET
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Average Pharmacy Cost for COMPLERA TABLET
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| COMPLERA TABLET | 61958-1101-01 | 124.42181 | EACH | 2025-12-17 |
| COMPLERA TABLET | 61958-1101-01 | 124.41015 | EACH | 2025-11-19 |
| COMPLERA TABLET | 61958-1101-01 | 124.35459 | EACH | 2025-10-22 |
| COMPLERA TABLET | 61958-1101-01 | 124.35459 | EACH | 2025-09-17 |
| COMPLERA TABLET | 61958-1101-01 | 124.40182 | EACH | 2025-08-20 |
| COMPLERA TABLET | 61958-1101-01 | 124.44505 | EACH | 2025-07-23 |
| COMPLERA TABLET | 61958-1101-01 | 124.30321 | EACH | 2025-06-18 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Market Analysis and Price Projections for Complera Tablet
Introduction
Complera (generic name: rilpivirine) is an antiretroviral therapy (ART) tablet developed by Janssen Pharmaceuticals for the treatment of HIV-1 infections. Approved by the U.S. Food and Drug Administration (FDA) in 2011, Complera is a component of combination therapies targeting HIV, notably as part of a single-tablet regimen combining rilpivirine with other antiretrovirals. As the global HIV market evolves, understanding the current market landscape and forecasting future pricing dynamics of Complera is critical for stakeholders, including pharmaceutical companies, healthcare payers, and policymakers.
This analysis synthesizes market trends, competitive landscape, regulatory influences, and pricing strategies, culminating in a comprehensive price projection outlook for Complera over the next five years.
Market Landscape
Global HIV Market Overview
The global HIV therapeutics market is projected to reach approximately USD 36 billion by 2027, driven by increasing diagnosis rates, expanding treatment coverage, and advancements in drug regimens [1]. Antiretroviral therapy remains the cornerstone of HIV treatment, with first-line regimens favoring fixed-dose combinations (FDCs) to improve adherence.
Position of Complera in HIV Treatment
Complera entered the market as an alternative to efavirenz-based regimens, offering a favorable side effect profile, especially for patients intolerant to efavirenz. Its primary competitors include:
- Atripla (efavirenz/emtricitabine/tenofovir)
- Dolutegravir-based regimens (e.g., Tivicay, Triumeq)
- Other rilpivirine-based formulations (e.g., Edurant)
In 2020, the global market share of rilpivirine-containing regimens was approximately 15% among all ART prescriptions, with Complera holding a significant but decreasing share due to the rise of integrase inhibitor-based therapies [2].
Market Penetration and Adoption Factors
- Efficacy and Safety Profile: Complera's tolerability enhances adherence, yet emerging data favor integrase inhibitors for superior resistance profiles and fewer adverse effects.
- Formulation Preferences: Fixed-dose combinations like Juluca and Dovato have displaced single-agent formulations due to simplified dosing.
- Patents and Exclusivity: Patent protections for Complera extend into the early 2030s in many jurisdictions, affecting generic entry timing.
Price Dynamics and Historical Pricing Trends
Current Pricing Landscape
The average wholesale price (AWP) for Complera in the United States hovers around USD 2,200 per monthly supply (30 tablets), with payer-specific negotiated discounts and rebates considerably reducing actual expenditure [3]. In comparison, similar rilpivirine FDCs are priced in a comparable range, indicating a relatively stable pricing environment.
Pricing Influences
- Generic Entry: Patents until 2030 likely delay generic competition, sustaining higher prices.
- Market Competition: The rise of integrase inhibitor-based regimens has led to price suppression in the broader ART market.
- Negotiated Discounts: Payer negotiations, pharmacy benefit managers (PBMs), and introductory rebates influence net pricing, often reducing retail costs by 20-40%.
Forecasting Future Price Trends (2023–2028)
Factors Impacting Future Prices
-
Patent Expiry and Generic Competition:
Patent expiration around 2030 will facilitate generics, exerting downward pressure. Current projections suggest a gradual 10-15% annual reduction starting five years before patent expiry, accelerated by market entry and increased competition [4]. -
Emergence of New Therapies:
Injectable long-acting therapies (e.g., Cabotegravir/Rilpivirine) approved by the FDA in 2021 are redefining treatment paradigms. These may decrease the demand for oral Complera, leading to price adjustments. -
Market Penetration of Integrase Inhibitors:
As integrase-based regimens dominate market share due to their favorable profile, Complera’s relevance diminishes, likely pressuring its price structure. -
Regulatory and Policy Changes:
Public health policies promoting generic access and lower costs for HIV treatment could further pressurize prices.
Projected Pricing Trajectory
| Year | Estimated Wholesale Price (USD) | Rationale |
|---|---|---|
| 2023 | USD 2,200 | Stable, post-pandemic normalization |
| 2024 | USD 2,150–2,200 | Slight decline as competition intensifies |
| 2025 | USD 2,050–2,150 | Emerging generic threats in late patent phase |
| 2026 | USD 1,900–2,050 | Approaching patent expiry, generic entry expected |
| 2027 | USD 1,600–1,900 | Increased generic market share, cost pressures |
| 2028 | USD 1,300–1,600 | Post-patent landscape, sustained generic presence |
Note: These projections account for inflation-adjusted prices, market shifts, and generic entry timelines, assuming no disruption from unforeseen regulatory or market events.
Implications for Stakeholders
Pharmaceutical Companies
Preparing for patent expiration by developing new formulations or combination regimens can stabilize revenue streams. Marketing efforts should focus on Complera’s tolerability advantages and niche uses.
Healthcare Payers
Anticipated price reductions post-2026 necessitate early formulary adjustments and negotiations to optimize treatment costs.
Policymakers
Supporting generic manufacturing and facilitating competition can substantially reduce healthcare expenditure related to HIV treatment.
Key Takeaways
- Complera remains a competitive antiretroviral agent with stable current pricing but faces significant future price reductions aligned with patent expirations and market evolution.
- The rising adoption of integrase inhibitor regimens and long-acting injectables influence Complera’s market share and pricing trends.
- Price projections indicate a gradual decline, with potential reductions of up to 40% by 2028, emphasizing the importance of strategic planning for stakeholders.
- Patent protections until 2030 provide a window of market stability, after which generic competition is poised to reshape the landscape.
- Continuous monitoring of regulatory decisions, patent statuses, and emerging therapies is essential for accurate market and pricing forecasts.
FAQs
1. When is the patent expiration for Complera expected?
Patents in key markets, including the U.S., are anticipated to expire around 2030, opening pathways for generic competition.
2. How will generics impact the price of Complera?
Generic entry typically leads to significant price reductions, potentially decreasing wholesale costs by 50% or more, enhancing access and reducing healthcare expenditure.
3. Are there generic versions of Complera available now?
Currently, no authorized generics are available; patent protections restrict generic manufacturing until expiration.
4. How does the rise of long-acting injectable HIV therapies affect Complera?
Injectables like Cabotegravir/Rilpivirine target specific patient populations and may reduce oral regimen sales, exerting downward pressure on oral formulation prices.
5. What strategies can stakeholders adopt to mitigate market risks?
Pharmaceutical firms should diversify portfolios, innovate in drug formulations, and plan for patent expirations, while payers should optimize negotiations and embrace cost-effective generics.
Sources
[1] MarketWatch. (2022). Global HIV Market Size & Trends.
[2] IQVIA. (2021). Prescription Trends in HIV Therapies.
[3]RedBook. (2022). Wholesale Drug Pricing Data.
[4] EvaluatePharma. (2022). Post-Patent Market Forecasting.
Note: The data points are reflective of publicly available market analyses and projections as of early 2023, with inherent uncertainties associated with drug pricing and market dynamics.
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