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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR VEMURAFENIB


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All Clinical Trials for vemurafenib

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00949702 ↗ A Study of Vemurafenib in Previously Treated Patients With Metastatic Melanoma Completed Hoffmann-La Roche Phase 2 2009-09-30 This open-label single arm study will assess the efficacy, safety and tolerability of Vemurafenib in previously treated patients with metastatic melanoma. Patients will receive oral Vemurafenib [RG7204; PLEXXIKON: PLX4032] at a dose of 960 mg b.i.d. continuously until disease progression or withdrawal from study and will be assessed at regular intervals for tumour response and tolerability. Target sample size is <100 patients.
NCT01006980 ↗ A Study of Vemurafenib (RO5185426) in Comparison With Dacarbazine in Previously Untreated Patients With Metastatic Melanoma (BRIM 3) Completed Hoffmann-La Roche Phase 3 2010-01-01 This randomized, open-label study evaluated the efficacy, safety and tolerability of vemurafenib (RO5185426) as compared to dacarbazine in previously untreated patients with metastatic melanoma. Patients were randomized to receive either vemurafenib 960 mg orally twice daily or dacarbazine 1000 mg/m2 intravenously every 3 weeks. Study treatment was continued until disease progression or unacceptable toxicity occurred. The data and safety monitoring board recommended that patients in the dacarbazine group be allowed to cross over to receive vemurafenib, and the protocol was amended accordingly on January 14, 2011, as both overall survival and progression-free survival endpoints had met the prespecified criteria for statistical significance in favor of vemurafenib.
NCT01271803 ↗ A Study of Vemurafenib and GDC-0973 (Cobimetinib) in Participants With BRAFV600E Mutation-Positive Metastatic Melanoma Completed Hoffmann-La Roche Phase 1 2011-02-17 This open-label, dose-escalation study of vemurafenib in combination with cobimetinib will evaluate the safety, tolerability and pharmacokinetics in participants with BRAFV600 mutation-positive metastatic melanoma. Participants with previously untreated, BRAFV600E mutation-positive, locally advanced/unresectable or metastatic melanoma or those who have progressed on vemurafenib monotherapy immediately prior to enrolling in this trial are eligible. Participants will be assigned to different cohorts with escalating oral doses of vemurafenib and cobimetinib. This study consists of 2 stages, Stage 1 (Dose Escalation Stage [DES] and Cohort Expansion Stage [CES]) and the anticipated time on study treatment is until disease progression, unacceptable toxicity or any other discontinuation criterion is met.
NCT01286753 ↗ A Study of Vemurafenib (RO5185426) in Participants With Metastatic or Unresectable Papillary Thyroid Cancer Positive for the BRAF V600 Mutation Completed Hoffmann-La Roche Phase 2 2011-06-01 This open-label, multi-center study will evaluate the safety and efficacy of Vemurafenib (RO5185426) in participants with metastatic or unresectable papillary thyroid cancer (PTC) positive for the BRAF V600 mutation and resistant to radioactive iodine therapy. Participants will receive vemurafenib 960 milligrams (mg) orally twice daily until progressive disease or unacceptable toxicity occurs.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for vemurafenib

Condition Name

Condition Name for vemurafenib
Intervention Trials
Melanoma 38
Malignant Melanoma 17
Metastatic Melanoma 9
Malignant Melanoma, Neoplasms 6
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Condition MeSH

Condition MeSH for vemurafenib
Intervention Trials
Melanoma 87
Neoplasms 18
Colorectal Neoplasms 10
Neoplasm Metastasis 10
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Clinical Trial Locations for vemurafenib

Trials by Country

Trials by Country for vemurafenib
Location Trials
United States 577
Italy 129
Spain 77
Australia 60
Germany 45
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Trials by US State

Trials by US State for vemurafenib
Location Trials
California 36
Texas 34
New York 34
Massachusetts 27
Florida 27
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Clinical Trial Progress for vemurafenib

Clinical Trial Phase

Clinical Trial Phase for vemurafenib
Clinical Trial Phase Trials
Phase 4 4
Phase 3 9
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for vemurafenib
Clinical Trial Phase Trials
Completed 51
Recruiting 35
Active, not recruiting 23
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Clinical Trial Sponsors for vemurafenib

Sponsor Name

Sponsor Name for vemurafenib
Sponsor Trials
Hoffmann-La Roche 32
Genentech, Inc. 25
National Cancer Institute (NCI) 13
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Sponsor Type

Sponsor Type for vemurafenib
Sponsor Trials
Other 144
Industry 97
NIH 14
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