Trilostane for Androgen-Independent Prostate Cancer
Completed
Genzyme, a Sanofi Company
Phase 2
2004-03-01
The main purpose of this study is to test the safety of trilostane by looking at what
effects, good and bad, it has on patients with androgen-independent prostate cancer.
Randomized Study of Letrozole and Trilostane for Medical Abortion
Terminated
Karolinska Institutet
Phase 2
2012-05-01
In menstruation an effective shedding of the endometrial lining occurs. Both progesterone and
estrogen levels fall sharply at this time. During medical abortion the endometrial shedding
is sometimes ineffective causing an incomplete abortion which may cause prolonged bleeding or
require surgical intervention. In medical abortion a progesterone antagonist is used as
treatment but the estrogen levels are not targeted. The investigators wish to explore whether
addition of letrozole or trilostane which target estrogen levels can lead to a more effective
shedding of the endometrial lining.
Randomized Study of Letrozole and Trilostane for Medical Abortion
Terminated
The University of Hong Kong
Phase 2
2012-05-01
In menstruation an effective shedding of the endometrial lining occurs. Both progesterone and
estrogen levels fall sharply at this time. During medical abortion the endometrial shedding
is sometimes ineffective causing an incomplete abortion which may cause prolonged bleeding or
require surgical intervention. In medical abortion a progesterone antagonist is used as
treatment but the estrogen levels are not targeted. The investigators wish to explore whether
addition of letrozole or trilostane which target estrogen levels can lead to a more effective
shedding of the endometrial lining.
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