Intranasal Dexmedetomidine vs Oral Triclofos Sodium for EEG in Children With Autism
Not yet recruiting
Rabin Medical Center
Phase 4
2020-03-01
Children with Autistic Spectrum Disorder (ASD) often undergo an Electroencephalography (EEG)
as part of routine work up. These children present a challenge to successful EEG execution,
due to a lack of co-operation, and thus, are often in need of sedation. Historically we have
used orally administered, Triclofos Sodium (TFS) - pharmacologically and physiologically
similar to chloral hydrate, for sedation in this age group. However success using this drug
is limited to approximately 75% in those aged 5 years and above, and possibly lower in this
age group when associated with a diagnosis of ASD. The medication is often poorly tolerated
by the oral route, and involves patient agitation, spiting (with incomplete drug ingestion),
and immediate vomiting upon administration. Recently we have introduced Intra-nasal
Dexmedetomidine (IN DEX), with an initial impression of much improved drug acceptance and
possibly improved efficacy over TFS.
We designed this pilot study, with the aim of comparing efficacy, tolerance of drug
administration and adverse events between TFS and IN DEX, with the goal of generating initial
results as well as feasibility of recruitment for a larger trial.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.
Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.
The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free.
thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user.
Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.
Alerts Available With Subscription
Alerts are available for users with active subscriptions.
