CLINICAL TRIALS PROFILE FOR TERIFLUNOMIDE

All Clinical Trials for teriflunomide

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00134563 ↗	Study of Teriflunomide in Reducing the Frequency of Relapses and Accumulation of Disability in Patients With Multiple Sclerosis	Completed	Sanofi	Phase 3	2004-09-01	The primary objective was to determine the effect of teriflunomide on the frequency of relapses in patients with relapsing multiple sclerosis (MS). Secondary objectives were: - to evaluate the effect of teriflunomide on the accumulation of disability as measured by Expanded Disability Status Scale [EDSS], the burden of disease as measured by Magnetic Resonance Imaging [MRI] and patient-reported fatigue; - to evaluate the safety and tolerability of teriflunomide.
NCT00228163 ↗	Long Term Safety and Efficacy of Teriflunomide (HMR1726) in Multiple Sclerosis With Relapses	Completed	Sanofi	Phase 2	2002-01-01	The primary objective is to assess the long-term safety of teriflunomide in multiple sclerosis subjects. The secondary objective is to assess the long-term efficacy.
NCT00475865 ↗	Phase II Study of Teriflunomide as Adjunctive Therapy to Glatiramer Acetate in Subjects With Multiple Sclerosis	Completed	Sanofi	Phase 2	2007-04-01	The primary objective was to estimate the tolerability and safety of 2 doses of Teriflunomide administered once daily for 24 weeks, compared to placebo, in patients with multiple sclerosis [MS] with relapses who were on a stable dose of Glatiramer Acetate [GA]. The secondary objectives were: - to estimate the effect of the 2 doses of Teriflunomide, compared to placebo, in combination with a stable dose of GA on Magnetic Resonance Imaging [MRI] parameters, relapse rate and patient-reported fatigue; - to perform pharmacokinetic analyses of the 2 doses of teriflunomide in combination with a stable dose of GA.
NCT00489489 ↗	Phase II Study of Teriflunomide as Adjunctive Therapy to Interferon-beta in Subjects With Multiple Sclerosis	Completed	Sanofi	Phase 2	2007-05-01	The primary objective was to estimate the tolerability and safety of 2 doses of teriflunomide administered once daily for 24 weeks, compared with placebo, in patients with multiple sclerosis [MS] with relapses who were on a stable dose of interferon-β [IFN-β]. Secondary objectives were: - to estimate the effects of the 2 doses of teriflunomide, compared to placebo, in combination with a stable dose of IFN-β on Magnetic Resonance Imaging [MRI] parameters, relapse rate and patient-reported fatigue; - to perform pharmacokinetic analyses of the 2 doses of teriflunomide in combination with a stable dose of IFN-β.

Clinical Trial Conditions for teriflunomide

Condition Name

Condition Name for teriflunomide
Intervention	Trials
Multiple Sclerosis	24
Relapsing Multiple Sclerosis	10
Relapsing Multiple Sclerosis (RMS)	2
Relapsing Remitting Multiple Sclerosis	2

Condition MeSH

Condition MeSH for teriflunomide
Intervention	Trials
Multiple Sclerosis	42
Sclerosis	39
Multiple Sclerosis, Relapsing-Remitting	4
Multiple Sclerosis, Chronic Progressive	2

Clinical Trial Locations for teriflunomide

Trials by Country

Trials by Country for teriflunomide
Location	Trials
United States	318
Canada	39
Spain	36
Italy	34
Germany	25

Trials by US State

Trials by US State for teriflunomide
Location	Trials
Florida	19
Ohio	16
California	16
Michigan	14
Tennessee	13

Clinical Trial Progress for teriflunomide

Clinical Trial Phase

Clinical Trial Phase for teriflunomide
Clinical Trial Phase	Trials
Phase 4	7
Phase 3	25
Phase 2	7

Clinical Trial Status

Clinical Trial Status for teriflunomide
Clinical Trial Phase	Trials
Completed	24
Recruiting	13
Active, not recruiting	8

Clinical Trial Sponsors for teriflunomide

Sponsor Name

Sponsor Name for teriflunomide
Sponsor	Trials
Sanofi	20
Novartis Pharmaceuticals	5
Genzyme, a Sanofi Company	4

Sponsor Type

Sponsor Type for teriflunomide
Sponsor	Trials
Industry	41
Other	20
NIH	5