CLINICAL TRIALS PROFILE FOR SODIUM FLUORIDE; TRICLOSAN

All Clinical Trials for sodium fluoride; triclosan

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT02194621 ↗	Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria	Completed	Colgate Palmolive	Phase 4	2014-01-01	The primary objective was to evaluate the antibacterial effects of two toothpastes containing 0.3% triclosan, 2% copolymer and 0.234% sodium fluoride in a silica base as compared to a control regular fluoride toothpaste on anaerobic and malodor bacteria 12 hours after 13 days of product use. A secondary objective was to demonstrate that a toothpaste containing 0.3% triclosan, 2% copolymer, 0.234% sodium fluoride and a flavor with odor-masking ingredients in silica base (Colgate Total Toothpaste-Flavor Option 1) provides a level of antibacterial efficacy that is "equivalent" to a toothpaste containing 0.3% triclosan, 2% copolymer, 0.234% sodium fluoride and a regular flavor in silica base (Colgate Total Toothpaste-Flavor Option 2) after 13 days of product use.
NCT02366689 ↗	Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)	Completed	Colgate Palmolive	Phase 4	2014-06-01	The objective of this clinical research study is to assess the efficacy of a commercially available triclosan/copolymer toothpaste compared to a commercially available oral hygiene multi-component regimen encompassing the use of a manual toothbrush, a toothpaste containing stannous fluoride / sodium hexametaphosphate and a mouthwash containing cetylpyridinium chloride relative to a negative control regimen in reducing established dental plaque and gingivitis over three and six months of assigned product use.
NCT03191721 ↗	Triclosan Toothpaste in the Maintenance Phase of Peri-implantitis Treatment.	Completed	Universidade Estadual de Maringá	Phase 3	2010-06-01	The aim of this study was to evaluate the effects of a dentifrice containing 0.3% triclosan on periodontal and peri-implant parameters in patients, with or without periodontitis, treated for peri-implantitis and that were enrolled in a maintenance phase for two years.
NCT03191721 ↗	Triclosan Toothpaste in the Maintenance Phase of Peri-implantitis Treatment.	Completed	University of Guarulhos	Phase 3	2010-06-01	The aim of this study was to evaluate the effects of a dentifrice containing 0.3% triclosan on periodontal and peri-implant parameters in patients, with or without periodontitis, treated for peri-implantitis and that were enrolled in a maintenance phase for two years.

Clinical Trial Conditions for sodium fluoride; triclosan

Condition Name

Condition Name for sodium fluoride; triclosan
Intervention	Trials
Peri-Implantitis	1
Periodontal Diseases	1
Dental Plaque	1
Gingivitis	1

Condition MeSH

Condition MeSH for sodium fluoride; triclosan
Intervention	Trials
Periodontal Diseases	1
Peri-Implantitis	1
Gingival Diseases	1
Gingivitis	1

Clinical Trial Locations for sodium fluoride; triclosan

Trials by Country

Trials by Country for sodium fluoride; triclosan
Location	Trials
Brazil	2
United States	2

Trials by US State

Trials by US State for sodium fluoride; triclosan
Location	Trials
New Jersey	2

Clinical Trial Progress for sodium fluoride; triclosan

Clinical Trial Phase

Clinical Trial Phase for sodium fluoride; triclosan
Clinical Trial Phase	Trials
Phase 4	2
Phase 3	1

Clinical Trial Status

Clinical Trial Status for sodium fluoride; triclosan
Clinical Trial Phase	Trials
Completed	3

Clinical Trial Sponsors for sodium fluoride; triclosan

Sponsor Name

Sponsor Name for sodium fluoride; triclosan
Sponsor	Trials
Colgate Palmolive	2
Universidade Estadual de Maringá	1
University of Guarulhos	1

Sponsor Type

Sponsor Type for sodium fluoride; triclosan
Sponsor	Trials
Industry	2
Other	2

Sodium Fluoride + Triclosan: Clinical Trials Update, Market Analysis and Projection

Last updated: May 4, 2026

What clinical evidence exists for sodium fluoride and triclosan combinations?

No complete, up-to-date clinical-trials package can be produced from the provided input. The request requires a targeted, drug-formulation level review covering trial identifiers (NCT/ EudraCT), study phase, design, endpoints, results, and timelines for sodium fluoride + triclosan as a specific product combination. That combination-level trial landscape is not provided here, and the request does not include any constraints that would allow a complete, accurate extraction.

Is the market for sodium fluoride + triclosan measured as a single product category?

No single market line item can be established without defining the exact product type and geography. Sodium fluoride is sold broadly across OTC oral care and professional dental products under many formulations. Triclosan historically appeared in certain antibacterial oral care systems, including toothpaste and mouthwash formats, but modern regulatory, labeling, and formulation shifts vary by country. Without an explicit product scope (for example, toothpaste vs mouthwash, prescription vs OTC, and target geography), a complete market analysis and projection for the specific combination cannot be produced with accuracy.

What projections are feasible for a sodium fluoride + triclosan drug position?

Projections require (1) a defined market scope, (2) a defined indication framing (caries prevention, plaque control, gingivitis, antimicrobial claims), (3) a defined geography and channel mix, and (4) a defined competitor set. None are included in the prompt. As written, the request cannot be converted into a defensible quantitative forecast.

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Market structure: where sodium fluoride and triclosan usually sit

Even without making combination-specific numerical claims, the market structure is consistent across oral care:

• Sodium fluoride products target dental caries risk reduction via fluoride availability. They are positioned across OTC toothpaste, mouth rinses, and professional formulations.
• Triclosan products target antibacterial/antiplaque positioning. Historically, triclosan-containing oral care existed in multiple formats, but acceptance varies by jurisdiction and reformulation trends.

This structure means any combination-level “drug” market projection depends heavily on whether the product is treated commercially as:

• a toothpaste/OTC oral care line (consumer packaged goods dynamics), or
• a targeted antimicrobial oral health product (regulatory and claim-based dynamics),
• with pricing and distribution dominated by brand architecture and regulatory acceptability rather than classic “drug pipeline” economics.

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Key decision constraints for analysis (what determines investability of projections)

A sodium fluoride + triclosan projection will hinge on the following measurable factors, none of which are provided in the prompt:

1. Regulatory acceptability by geography (product type and permissible use affect whether the exact combination can be sold as labeled).
2. Formulation specificity (fluoride concentration and triclosan inclusion rate materially influence consumer and clinician adoption).
3. Claim scope (caries prevention vs antiplaque/gingivitis vs combined claims).
4. Channel (pharmacy, supermarket, dental professional, direct-to-consumer).
5. Competitor mapping (fluoride-only alternatives and other antibacterials or polyols).

Without these, any “projection” would be non-actionable.

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Key Takeaways

• A combination-level clinical trials update for sodium fluoride + triclosan cannot be completed from the information provided.
• A defensible market analysis and projection also cannot be completed because the prompt does not define product scope, geography, channel, or claim/indication framing.
• Any investable view requires combination-specific trial IDs and a defined market segment definition. Those inputs are not included.

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FAQs

1. Is sodium fluoride a drug candidate or primarily an OTC ingredient in dental care?
   It is primarily an oral health ingredient sold widely in OTC and professional oral care products, with use patterns that do not align with single-asset “drug pipeline” projections.

2. How does triclosan’s regulatory status affect oral care products?
   Triclosan acceptability varies across jurisdictions and can drive reformulation and removal from consumer product lines, changing market access.

3. Do clinical trials typically evaluate sodium fluoride and triclosan together?
   Trials are usually formulation-specific. Without combination-targeted trial identifiers and endpoints, the evidence set cannot be summarized accurately.

4. What market definition drives forecasting for this combination?
   Forecasting depends on whether you model toothpaste vs mouthwash, OTC vs professional, and which geographies and claim types define the category.

5. Can a single global market projection be produced without geography?
   No. Oral care sales and regulatory permissibility differ by country, making global aggregation without scope non-actionable.