CLINICAL TRIALS PROFILE FOR PROBENECID

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All Clinical Trials for probenecid

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00000670 ↗	Safety and Tolerance of Zidovudine With Probenecid and the Effect of Probenecid on Zidovudine Pharmacokinetics Over Four Weeks	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	N/A	1969-12-31	To evaluate the interaction of probenecid with zidovudine (AZT). Because AZT is eliminated quickly from the body, it must be taken frequently. A previous study showed that probenecid slowed the elimination of AZT without side effects, but that study lasted only 5 days. This study is to see whether this effect continues for 1 month and whether the continuation of probenecid and AZT is free of side effects over 1 month.
NCT00000706 ↗	Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	N/A	1969-12-31	Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and eliminated through the kidneys in HIV infected patients. Part II studies the effect of probenecid and quinine on the same aspects. Because AZT leaves the bloodstream quickly, patients must take the drug frequently to keep adequate amounts in their bodies. Probenecid and quinine may slow down the rate at which AZT leaves the body. Therefore, taking these drugs along with AZT may reduce the amount of AZT needed for treatment.
NCT00000799 ↗	HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol	Completed	Gilead Sciences	N/A	1969-12-31	To evaluate short-term and long-term safety and efficacy of intravenous cidofovir (HPMPC) for treatment of small peripheral cytomegalovirus (CMV) retinitis lesions. To provide data on the relative safety and efficacy of 2 doses of HPMPC as maintenance regimens.
NCT00000799 ↗	HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	N/A	1969-12-31	To evaluate short-term and long-term safety and efficacy of intravenous cidofovir (HPMPC) for treatment of small peripheral cytomegalovirus (CMV) retinitis lesions. To provide data on the relative safety and efficacy of 2 doses of HPMPC as maintenance regimens.

Clinical Trial Conditions for probenecid

Condition Name

Condition Name for probenecid
Intervention	Trials
HIV Infections	10
Cytomegalovirus Retinitis	7
Healthy	7
Urinary Tract Infections	4

Condition MeSH

Condition MeSH for probenecid
Intervention	Trials
HIV Infections	11
Communicable Diseases	8
Retinitis	7
Cytomegalovirus Retinitis	7

Clinical Trial Locations for probenecid

Trials by Country

Trials by Country for probenecid
Location	Trials
United States	196
Canada	10
Germany	7
South Africa	6
Poland	5

Trials by US State

Trials by US State for probenecid
Location	Trials
California	16
Texas	14
Ohio	10
New York	10
Florida	8

Clinical Trial Progress for probenecid

Clinical Trial Phase

Clinical Trial Phase for probenecid
Clinical Trial Phase	Trials
PHASE2	2
PHASE1	4
Phase 4	6

Clinical Trial Status

Clinical Trial Status for probenecid
Clinical Trial Phase	Trials
Completed	47
Not yet recruiting	11
Recruiting	6

Clinical Trial Sponsors for probenecid

Sponsor Name

Sponsor Name for probenecid
Sponsor	Trials
National Institute of Allergy and Infectious Diseases (NIAID)	8
Iterum Therapeutics, International Limited	6
National Institutes of Health (NIH)	5

Sponsor Type

Sponsor Type for probenecid
Sponsor	Trials
Industry	45
Other	35
NIH	21