CLINICAL TRIALS PROFILE FOR PIPECURONIUM BROMIDE
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All Clinical Trials for pipecuronium bromide
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT05693428 ↗ | Influence of Anesthetics on Clinical Outcome During Cardiac Surgery in Adults | Completed | Astana Medical University | N/A | 2022-01-22 | Abstract Cardiac surgery in adults is associated with the occurrence of post-operative complications. Even minor complications can increase the cost of their treatment. Given the potentially preventable nature of a number of these postoperative complications, preventive methods should be used to improve outcomes after cardiac surgery. One of them, is the choice of anaesthetic technique. Objectives: To evaluate the effects of sevoflurane, isoflurane and propofol on blood oxygen transport function and body energy expenditure during cardiac surgery in adults. Materials and methods. A total of 90 patients were included in the study. All patients were divided into 3 groups: 1- (n=30) included patients who were anesthetized with propofol. The second group (n=30) consisted of patients who underwent sevoflurane inhalation anaesthesia. Group 3 (n=30) was treated with isoflurane. All patients underwent coronary artery bypass grafting under cardiopulmonary bypass. |
| NCT05695287 ↗ | The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery | Completed | Astana Medical University | Phase 1 | 2021-01-22 | Abstract Anaesthetic support for cardiac surgery significantly influences the course of the intraoperative period and the success of the postoperative period. Total intravenous anaesthesia and inhalation anaesthesia are the traditional methods of anaesthesia in cardiac surgery. However, there are few studies assessing the effectiveness of surgical aggression protection in cardiac surgery. Objectives: To study the effectiveness of body protection against surgical aggression by TIVA and inhalational anaesthesia in cardiac surgery. Materials and methods. The examination and treatment data of 89 patients were included in the study. All patients underwent coronary artery bypass grafting, mitral valve replacement/plasty, aortic valve replacement cardiopulmonary bypass conditions. The patients were divided into 2 groups according to the type of disease: the first (1) group with coronary heart disease. The second (2) group with valvular heart disease. There were 65 patients in the first group and 22 in the second. Both groups were divided into 3 subgroups according to the type of anaesthesia: patients anaesthetised with propofol, with sevoflurane, with isoflurane. |
| NCT05742789 ↗ | Effect of Anesthetics on Cardiac Biomarkers in Mitral and Aortic Valve Replacement/Plasty | Completed | Astana Medical University | Phase 1 | 2021-11-30 | Abstract Cardiac troponin is one of the biomarkers of the heart, and its high level correlates with a high risk of damage to cardiomyocytes. Objective: To determine the effect of anesthetics on cardiac enzymes during mitral and aortic valve replacement in adults. methods. Single-center prospective randomized controlled clinical study. A total of 255 patients were assigned randomly into three groups according to the type of anesthesia: the first group of 85 patients with propofol, the second group with sevoflurane - 85 patients, and the last - 85 patients were with isoflurane. Cardiac troponin I levels were calculated in ng/mL using the i-CHROMAII portable fluorescent analyzer manufactured by BoditechMedInc. (South Korea). Normal range: <0.4 ng/mL. Cardiac index (CI=CO/body surface area), oxygen consumption (VO2 = Cardiac index (CI)*AVD or VO2 = CO × (CaO2 - CvO2) ~ CO × Hb × 1.34 × (SaO2 - SvO2) / 100) were determined before induction into anesthesia. |
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