Last Updated: November 10, 2026

CLINICAL TRIALS PROFILE FOR MIRDAMETINIB

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All Clinical Trials for mirdametinib

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Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT03905148 ↗	Study of the Safety and Pharmacokinetics of BGB-283 (Lifirfenib) and PD-0325901 (Mirdametinib) in Participants With Advanced or Refractory Solid Tumors	Recruiting	SpringWorks Therapeutics	Phase 1/Phase 2	2019-05-01	This is a 2-part Phase 1b study of BGB-283 (lifirafenib) and PD-0325901 (mirdametinib) combination in participants with tumors.
NCT03905148 ↗	Study of the Safety and Pharmacokinetics of BGB-283 (Lifirfenib) and PD-0325901 (Mirdametinib) in Participants With Advanced or Refractory Solid Tumors	Recruiting	SpringWorks Therapeutics, Inc.	Phase 1/Phase 2	2019-05-01	This is a 2-part Phase 1b study of BGB-283 (lifirafenib) and PD-0325901 (mirdametinib) combination in participants with tumors.
NCT03905148 ↗	Study of the Safety and Pharmacokinetics of BGB-283 (Lifirfenib) and PD-0325901 (Mirdametinib) in Participants With Advanced or Refractory Solid Tumors	Recruiting	BeiGene	Phase 1/Phase 2	2019-05-01	This is a 2-part Phase 1b study of BGB-283 (lifirafenib) and PD-0325901 (mirdametinib) combination in participants with tumors.
NCT03962543 ↗	MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas	Recruiting	SpringWorks Therapeutics, Inc.	Phase 2	2019-09-06	This study evaluates mirdametinib (PD-0325901) in the treatment of symptomatic inoperable neurofibromatosis type-1 (NF1)-associated plexiform neurofibromas (PNs). All participants will receive mirdametinib (PD-0325901).
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Start Date	>Summary

Clinical Trial Conditions for mirdametinib

Condition Name

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Condition Name for mirdametinib
Intervention	Trials
Well Differentiated Liposarcoma	1
Monotherapy	1
Plexiform Neurofibroma	1
Dedifferentiated Liposarcoma	1
[disabled in preview]	1
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Condition MeSH

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Condition MeSH for mirdametinib
Intervention	Trials
Neurofibromatoses	3
Neoplasms	2
Neurofibromatosis 1	2
Neurofibroma	2
[disabled in preview]	1
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Clinical Trial Locations for mirdametinib

Trials by Country

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Trials by Country for mirdametinib
Location	Trials
United States	42
Australia	4
Canada	1
France	1
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Trials by US State

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Trials by US State for mirdametinib
Location	Trials
Ohio	3
New York	3
New Jersey	3
Texas	2
Maryland	2
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Clinical Trial Progress for mirdametinib

Clinical Trial Phase

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Clinical Trial Phase for mirdametinib
Clinical Trial Phase	Trials
PHASE2	3
PHASE1	6
Phase 2	2
[disabled in preview]	5
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Clinical Trial Status

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Clinical Trial Status for mirdametinib
Clinical Trial Phase	Trials
RECRUITING	13
NOT_YET_RECRUITING	3
Not yet recruiting	1
[disabled in preview]	0
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Clinical Trial Sponsors for mirdametinib

Sponsor Name

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Sponsor Name for mirdametinib
Sponsor	Trials
SpringWorks Therapeutics, Inc.	7
National Cancer Institute (NCI)	2
Memorial Sloan Kettering Cancer Center	2
[disabled in preview]	1
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Sponsor Type

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Sponsor Type for mirdametinib
Sponsor	Trials
Other	13
Industry	9
NIH	2
[disabled in preview]	0
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