CLINICAL TRIALS PROFILE FOR METHAZOLAMIDE

All Clinical Trials for methazolamide

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00257829 ↗	Improving Tumor Oxygenation in Cervical Cancer	Withdrawn	University of California, Irvine	Phase 2	2004-07-01	The Phenomenon of Tumor Hypoxia Many solid tumors are relatively resistant to treatment with ionizing radiation and certain chemotherapeutic agents such as anthracyclines that are affected adversely by acidic pH. These effects have primarily been attributed to the presence of hypoxic cells within the tumor. The relevance of hypoxia with respect to failure of radiotherapy to cure certain malignancies has had a chequered history. However, in recent years the evidence that hypoxia plays a central role in relative radioresistance has become more compelling. Since approximately two-thirds of all women suffering from cervical carcinoma receive radiation as a component of their therapy, an enhanced understanding of the interactions between hypoxia and radiation as a component of their therapy, an enhanced understanding of the interactions between hypoxia and radiation resistance is critical to improving outcome among those with cervical cancer.
NCT01587027 ↗	Safety Evaluation of Aminophylline and Methazolamide	Completed	Defense Advanced Research Projects Agency	Phase 1	2011-12-01	This safety study is the first in a series of studies testing the application of the combination of aminophylline and methazolamide.
NCT01587027 ↗	Safety Evaluation of Aminophylline and Methazolamide	Completed	University of Colorado, Denver	Phase 1	2011-12-01	This safety study is the first in a series of studies testing the application of the combination of aminophylline and methazolamide.
NCT01587027 ↗	Safety Evaluation of Aminophylline and Methazolamide	Completed	Poudre Valley Health System	Phase 1	2011-12-01	This safety study is the first in a series of studies testing the application of the combination of aminophylline and methazolamide.
NCT01702025 ↗	Rapid Acclimatization to Hypoxia at Altitude	Completed	Defense Advanced Research Projects Agency	Phase 1/Phase 2	2012-06-01	In low oxygen environments, such as altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower altitudes (e.g. sea-level). The purpose of this investigation is to study the effects of two drugs that may help people adjust to high-altitude quickly, prevent them from becoming ill and improve their exercise performance. The drugs are Methazolamide and Aminophylline.
NCT01702025 ↗	Rapid Acclimatization to Hypoxia at Altitude	Completed	University of Colorado, Denver	Phase 1/Phase 2	2012-06-01	In low oxygen environments, such as altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower altitudes (e.g. sea-level). The purpose of this investigation is to study the effects of two drugs that may help people adjust to high-altitude quickly, prevent them from becoming ill and improve their exercise performance. The drugs are Methazolamide and Aminophylline.
NCT01702025 ↗	Rapid Acclimatization to Hypoxia at Altitude	Completed	Colorado State University	Phase 1/Phase 2	2012-06-01	In low oxygen environments, such as altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower altitudes (e.g. sea-level). The purpose of this investigation is to study the effects of two drugs that may help people adjust to high-altitude quickly, prevent them from becoming ill and improve their exercise performance. The drugs are Methazolamide and Aminophylline.

Clinical Trial Conditions for methazolamide

Condition Name

Condition Name for methazolamide
Intervention	Trials
Mountain Sickness	2
High Altitude Effects	1
Hypertension, Pulmonary	1
Hypoxia	1

Condition MeSH

Condition MeSH for methazolamide
Intervention	Trials
Altitude Sickness	4
Hypoxia	3
Glaucoma	2
Anoxia	1

Clinical Trial Locations for methazolamide

Trials by Country

Trials by Country for methazolamide
Location	Trials
United States	6
Canada	2

Trials by US State

Trials by US State for methazolamide
Location	Trials
Colorado	3
Michigan	2
Florida	1

Clinical Trial Progress for methazolamide

Clinical Trial Phase

Clinical Trial Phase for methazolamide
Clinical Trial Phase	Trials
PHASE2	1
Phase 4	5
Phase 3	1

Clinical Trial Status

Clinical Trial Status for methazolamide
Clinical Trial Phase	Trials
Completed	5
Not yet recruiting	2
Withdrawn	2

Clinical Trial Sponsors for methazolamide

Sponsor Name

Sponsor Name for methazolamide
Sponsor	Trials
University of Colorado, Denver	4
University of British Columbia	2
Defense Advanced Research Projects Agency	2

Sponsor Type

Sponsor Type for methazolamide
Sponsor	Trials
Other	14
U.S. Fed	2
NIH	1

Clinical Trials Update and Market Projection for Methazolamide

Last updated: April 28, 2026

What is methazolamide and what is the current clinical development state?

Methazolamide is a carbonic anhydrase inhibitor used as a systemic therapy for glaucoma and related pressure disorders. Publicly accessible trial-level updates that enable a current “clinical trials status by phase” view (active/completed/enrolling with dates and outcomes) are not provided in the available source material in this workspace. As a result, a complete and accurate clinical-trials update cannot be produced.

What does the market look like for methazolamide?

Methazolamide competes in the oral carbonic anhydrase inhibitor segment, where the core commercial dynamic is substitution among class members and off-label patterns, plus pressure-device and topical-first treatment pathways in ophthalmology.

Demand drivers

• Chronic ophthalmic use: Methazolamide is typically used to control intraocular pressure in chronic and acute scenarios where oral therapy is indicated.
• Class utility: As a carbonic anhydrase inhibitor, methazolamide is priced and positioned relative to other systemic agents and the prevailing topical standard-of-care.

Key commercial headwinds

• Topical-first ophthalmology pathways: Many markets treat glaucoma primarily with topical agents; oral agents are generally reserved for specific indications or insufficient response.
• Substitution within the class: Patients and prescribers can switch to other systemic carbonic anhydrase inhibitors when available, affecting pricing power and share stability.

Key commercial tailwinds

• Systemic fallback use: Oral therapy retains a role where rapid pressure reduction or multi-mechanism regimens are required.
• Formulation continuity: In markets where methazolamide remains available and reimbursed, it can maintain baseline demand independent of new clinical differentiation.

How should investors and R&D teams project the methazolamide opportunity?

A market projection requires at least one of the following: (1) current unit sales or revenue by geography, (2) pricing and reimbursement benchmarks, (3) current share vs comparable agents, or (4) explicit FDA/EMA regulatory status data tied to formulation and indications. None of these elements are present in the available source material, so a complete and accurate numeric projection cannot be produced.

What can be concluded without numeric projection

• Methazolamide is not a “platform” growth story: Commercial outlook is driven by generic competitiveness, topical substitution, and whether systemic use cases expand or contract in practice.
• Near-term value is defined by availability and access: Supply continuity, formulation quality, and reimbursement rules often determine revenue more than incremental clinical claims.

Competitor landscape: what does methazolamide trade against?

Methazolamide’s competitive set in oral carbonic anhydrase inhibition includes other systemic agents in the same therapeutic class used for intraocular pressure control. The competitive strategy depends on:

• Relative tolerability and dosing convenience
• Generic availability and pricing
• Therapeutic guideline placement for systemic escalation

A full competitor-by-competitor table (brand, generic status, label indications, and key trial claims) cannot be compiled from the available workspace sources.

What regulatory and lifecycle signals matter most?

Methazolamide is typically commercialized as a legacy molecule. For legacy therapies, lifecycle signals that change economics usually include:

• Formulation and bioequivalence constraints (manufacturing and labeling stability)
• Regulatory supply continuity (approvals, renewals, and discontinuations)
• Indication scope in local formularies

A current regulatory “as of” timeline for methazolamide cannot be produced from the available workspace sources.

Actionable business implications (R&D and investment)

R&D positioning

• Focus on real-world differentiation that impacts prescribing behavior: tolerability improvements, dosing simplification, or targeted new formulations that reduce adherence friction.
• If pursuing clinical differentiation, align trials to systemic glaucoma management gaps rather than broad reframing of carbonic anhydrase inhibition.

Investment positioning

• Treat methazolamide as a managed-access and generics-competitive asset, with revenue sensitivity to supply and pricing rather than blockbuster-type trial outcomes.
• Underwrite downside risk from topical-first guideline practice and substitution within the oral class.

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Key Takeaways

• A complete, accurate clinical trials update for methazolamide cannot be produced from the available sources in this workspace.
• A complete, numeric market analysis and projection also cannot be produced because unit/revenue, pricing, and share inputs are not present.
• Business outlook is shaped primarily by oral carbonic anhydrase inhibitor role, topical substitution, class interchangeability, and supply and access rather than novel clinical differentiation.

FAQs

1. Is methazolamide currently in active late-stage clinical development?
   A phase-by-phase active trial determination cannot be produced from the available workspace sources.

2. What is methazolamide used for in practice?
   It is used as a carbonic anhydrase inhibitor for intraocular pressure control, including glaucoma-related management.

3. How competitive is the oral carbonic anhydrase inhibitor segment?
   Competition is driven by substitution among class members and by topical-first standards that limit systemic escalation.

4. What factors determine methazolamide revenue stability?
   Availability, reimbursement/formulary access, pricing pressure, and substitution trends within the class.

5. What type of clinical evidence would most affect prescribing behavior?
   Evidence that reduces dosing burden, improves tolerability, or fills a specific systemic management need.

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References

[1] No sources were available in the provided workspace to cite for methazolamide clinical-trials status, market sizing, or regulatory history.