CLINICAL TRIALS PROFILE FOR MEPERIDINE HYDROCHLORIDE; PROMETHAZINE HYDROCHLORIDE
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All Clinical Trials for meperidine hydrochloride; promethazine hydrochloride
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT00937924 ↗ | Adjunct Sedatives in Procedures Involving Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) | Unknown status | University of California, Irvine | N/A | 2008-02-01 | The purpose of this study is to compare meperidine/midazolam with diphenhydramine, meperidine/midazolam with promethazine, and meperidine/midazolam with placebo as sedation methods. The investigators are interested to see whether adjunct sedatives (diphenhydramine and promethazine) will improve sedation. |
| NCT02145169 ↗ | Inhaled Nitrous Oxide for the Prevention of Emergence Reaction During Ketamine Administration in Adults, a Pilot Study | Completed | Albert Einstein Healthcare Network | N/A | 2013-10-01 | To describe the safety and efficacy of nitrous oxide during ketamine administration for the prevention of emergence reaction during Emergency Department procedural sedation and analgesia in adults. Drugs such as fentanyl, midazolam, and propofol are widely used in emergency departments for procedural sedation and analgesia because they have a rapid onset and short duration of action. Unfortunately, all of these agents may cause respiratory depression, particularly when combined with other sedative agents, administered in large doses, or given to patients with underlying respiratory diseases. Nitrous oxide use during ketamine administration may be an ideal combination for the prevention of emergence reaction in adults sedated in the ED. Like ketamine, nitrous oxide has an excellent cardio-respiratory profile as well as some analgesic and anxiolytic qualities. The anxiety and pain surrounding procedural sedation is not limited to the procedure itself, but the elapsed time from the time the patient enters the ED to the time spent in preparation for the procedure can be significant and lead to increased anxiety, which may exacerbate emergence reactions in adults. Using nitrous oxide before ketamine administration may mitigate this. While midazolam has shown efficacy in reducing emergence reactions in adults sedated with ketamine, the investigators believe that inhaled nitrous oxide may be equivalent to midazolam, with a better cardio-respiratory profile. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
Clinical Trial Conditions for meperidine hydrochloride; promethazine hydrochloride
Condition Name
| Condition Name for meperidine hydrochloride; promethazine hydrochloride | |
| Intervention | Trials |
| Emergence Reaction | 1 |
| Endoscopic Retrograde Cholangiopancreatography (ERCP) | 1 |
| Endoscopic Ultrasound (EUS) | 1 |
| Procedural Sedation | 1 |
| [disabled in preview] | 0 |
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Clinical Trial Locations for meperidine hydrochloride; promethazine hydrochloride
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Clinical Trial Progress for meperidine hydrochloride; promethazine hydrochloride
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Clinical Trial Sponsors for meperidine hydrochloride; promethazine hydrochloride
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