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Last Updated: January 24, 2020

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CLINICAL TRIALS PROFILE FOR LEVONORDEFRIN; MEPIVACAINE HYDROCHLORIDE

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All Clinical Trials for levonordefrin; mepivacaine hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00154167 Safety and Efficacy Study of NV-101 in Dental Patients Completed Novalar Pharmaceuticals, Inc. Phase 2 2003-02-01 The purpose of this study was: - to determine if NV-101 accelerates recovery from numbness compared to placebo - to evaluate safety of NV-101
NCT02603198 2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study Active, not recruiting University of Sao Paulo N/A 2014-08-01 Dental treatments, particularly third molars extraction, can become extremely uncomfortable and painful. They are associated to anxiety, fear and many other unpleasant sensations. During surgery, patients can present cardiorespiratory repercussions of these sensations. This fact generally justifies the employment of methods of monitoring and appliance of safer therapeutic alternatives. Local anesthetics are the most frequently drugs used in dentistry. Vasoconstrictors, particularly epinephrine, are important components of anesthetic solutions to increased time for anesthetic absorption and consequently increasing the duration of anesthesia. The use of smaller amounts of anesthetic solution can reduce the risk of systemic toxicity, however decrease the total surgical time. It is well known that the amount of epinephrine injected into patients during anesthetic procedures can produce adverse hemodynamic effects. Levonordefrin was adding to dental cartridges promising to reduce cardiac stimulation due it less β activity, and maintain the same clinical and systemic effects. But some studies for maxillary or intraosseous infiltrations showed no difference in heart rate and any anesthetic success over epinephrine. Thus, this study aims to compare the clinical efficacy and safety of anesthetic mepivacaine 2% with epinephrine 1:100,000 or 1:20,000 levonordefrin employing a clinical trial model of third molars extractions in healthy adults.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for levonordefrin; mepivacaine hydrochloride

Condition Name

Condition Name for levonordefrin; mepivacaine hydrochloride
Intervention Trials
Trismus 1
Soft Tissue Anesthesia (Numbness) 1
Pain 1
Edema 1
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Condition MeSH

Condition MeSH for levonordefrin; mepivacaine hydrochloride
Intervention Trials
Trismus 1
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Clinical Trial Locations for levonordefrin; mepivacaine hydrochloride

Trials by Country

Trials by Country for levonordefrin; mepivacaine hydrochloride
Location Trials
United States 1
Brazil 1
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Trials by US State

Trials by US State for levonordefrin; mepivacaine hydrochloride
Location Trials
Washington 1
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Clinical Trial Progress for levonordefrin; mepivacaine hydrochloride

Clinical Trial Phase

Clinical Trial Phase for levonordefrin; mepivacaine hydrochloride
Clinical Trial Phase Trials
Phase 2 1
N/A 1
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Clinical Trial Status

Clinical Trial Status for levonordefrin; mepivacaine hydrochloride
Clinical Trial Phase Trials
Active, not recruiting 1
Completed 1
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Clinical Trial Sponsors for levonordefrin; mepivacaine hydrochloride

Sponsor Name

Sponsor Name for levonordefrin; mepivacaine hydrochloride
Sponsor Trials
Novalar Pharmaceuticals, Inc. 1
University of Sao Paulo 1
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Sponsor Type

Sponsor Type for levonordefrin; mepivacaine hydrochloride
Sponsor Trials
Industry 1
Other 1
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