COmbined N-acetylcysteine and Bicarbonate in PCI To Reduce Adverse Side Effect of contrasT
National University Hospital, Singapore
Phase 2/Phase 3
This is a randomised controlled trial to investigate the efficacy of preventive regimen of
hydration with high dose oral N-acetylcysteine and intravenous sodium bicarbonate
pretreatment in patients with stable advanced renal insufficiency (CKD stage 3 and 4:GFR
15-60ml/min/1.73m2 calculated by Modification of Diet in Renal Disease Study equation (MDRD
formula)) undergoing elective percutaneous coronary intervention (PCI).
Endoscopic retrograde cholangiopancreatography (ERCP) is now a widely accepted therapy for
treating benign and malignant diseases of the pancreatobiliary tree. Acute pancreatitis
represents the most common and feared complication following ERCP. The reported incidence of
this complication is from 1% to 40% according to the presence of high-risk factors for this
complication or the presence dysfunction in the sphincter of Oddi (SOD). In most prospective
series, the incidence has ranged between 3.5% and 20% for nonselected and high-risk
patients, respectively. Independent risk factors for post-ERCP pancreatitis are either
patient- or procedure-related.
Abdominal CT to Predict the Risk of Acute Graft-versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
Washington University School of Medicine
Contrast-enhanced abdominal CT will be performed 1-2 weeks after allogeneic stem cell
transplant, and radiographic evidence of mucosal inflammation will be correlated with the
subsequent development of acute graft versus host disease. The primary endpoint is the
feasibility and safety of contrast-enhanced abdominal CT in the early post-transplant
period, as defined by the risk of contrast-related nephropathy or allergic reaction.
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