Intravenous (IV) Nitroglycerin for Versions in Nulliparous Women
Completed
University of Calgary
N/A
2003-03-01
Breech presentations (where a baby presents with feet or bottom down) have an increased risk
of perinatal and neonatal complications, and are usually delivered by cesarean section. As an
alternative, so that the baby can be delivered vaginally, an attempt can be made to turn the
baby so that it is head down: this manoeuvre is called an external cephalic version (ECV).
Drugs that relax the uterus (tocolytic agents) are sometimes used to help improve ECV success
rates. Nitroglycerin is a tocolytic agent, but intravenous nitroglycerin has not been tested
as an agent to help ECV. There is some suggestion that nitroglycerin may be more helpful in
women who have not previously been pregnant (nulliparous women) than in women who have been
pregnant more than once (multiparous women), and so we have planned two trials.
This study is designed to answer the following questions for nulliparous women:
Will administration of IV nitroglycerin for uterine relaxation improve ECV success rates?
Will an increase in ECV success result in a decreased cesarean section rate?
Oral Pilocarpine in the Treatment of the Dry Eye of Patients With Sjogrens Syndrome
Completed
Federal University of São Paulo
Phase 3
2005-03-01
The purpose of this study was to access the possible beneficial effects of oral use of
pilocarpine in relieving signs and symptoms of patients with Sjogren's syndrome
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