Allogeneic Transplantation From Related Haploidentical Donors
Completed
Stanford University
Phase 2
2000-08-01
The purpose of the study is to evaluate the feasibility and safety of transplanting CD34+
selected hematopoietic cells from a haploidentical related donor following a nonmyeloablative
regimen of total lymphoid irradiation (TLI) and antithymocyte globulin (ATG).
EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)
Terminated
Enzon Pharmaceuticals, Inc.
Phase 1
2010-08-24
An experimental drug called EZN-3042 targets survivin, a protein expressed in leukemia cells
at relapse that promotes the leukemia cells to grow. The main goal of this phase I study is
to find out the dose of EZN-3042 that can be safely given without serious side effects both
alone and in combination with standard chemotherapy drugs during re-induction.
EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)
Terminated
Therapeutic Advances in Childhood Leukemia Consortium
Phase 1
2010-08-24
An experimental drug called EZN-3042 targets survivin, a protein expressed in leukemia cells
at relapse that promotes the leukemia cells to grow. The main goal of this phase I study is
to find out the dose of EZN-3042 that can be safely given without serious side effects both
alone and in combination with standard chemotherapy drugs during re-induction.
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