CLINICAL TRIALS PROFILE FOR FLUOXETINE HYDROCHLORIDE; OLANZAPINE

All Clinical Trials for fluoxetine hydrochloride; olanzapine

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00000373 ↗	Treatment of Obsessive-Compulsive Disorder	Completed	National Institute of Mental Health (NIMH)	Phase 4	1992-09-01	The purpose of this study is to find the best treatment for Tourette's Syndrome (TS)-spectrum obsessive-compulsive disorder (OCD), which includes symptoms of TS, e.g., repeated and involuntary body movements (tics). There are 2 parts to this study: In Part 1, patients are placed into 1 of 2 groups based on type of OCD, determined by medical history and family member interviews. In Part 2, patients are treated with fluvoxamine (FVX) for 8 weeks. If patients do not respond to FVX alone, either haloperidol or an inactive placebo will be added to the FVX regimen; patients will take this drug combination for 4 weeks. Patients will be monitored throughout the trial.
NCT00000373 ↗	Treatment of Obsessive-Compulsive Disorder	Completed	University of Florida	Phase 4	1992-09-01	The purpose of this study is to find the best treatment for Tourette's Syndrome (TS)-spectrum obsessive-compulsive disorder (OCD), which includes symptoms of TS, e.g., repeated and involuntary body movements (tics). There are 2 parts to this study: In Part 1, patients are placed into 1 of 2 groups based on type of OCD, determined by medical history and family member interviews. In Part 2, patients are treated with fluvoxamine (FVX) for 8 weeks. If patients do not respond to FVX alone, either haloperidol or an inactive placebo will be added to the FVX regimen; patients will take this drug combination for 4 weeks. Patients will be monitored throughout the trial.
NCT00035321 ↗	The Study of Olanzapine Plus Fluoxetine in Combination for Treatment of Treatment Resistant Depression	Completed	Eli Lilly and Company	Phase 3	2002-04-01	The purposes of this study are to determine: - Whether olanzapine plus fluoxetine in combination will help patients with treatment-resistant major depression. - The safety of olanzapine plus fluoxetine in combination, plus and any side effects that might be associated with the combination. - The effectiveness of olanzapine plus fluoxetine compared to olanzapine and fluoxetine alone.
NCT00188942 ↗	A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder	Completed	Eli Lilly and Company	Phase 4	2005-02-01	This study employs functional magnetic resonance imaging to compare brain activation patterns during a depressive episode in patients diagnosed with bipolar disorder, major depressive disorder, and a group of healthy control subjects. Depressed patients will be treated with a combination of fluoxetine and olanzapine and undergo MRI scans before, during, and after pharmacotherapy.
NCT00188942 ↗	A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder	Completed	University Health Network, Toronto	Phase 4	2005-02-01	This study employs functional magnetic resonance imaging to compare brain activation patterns during a depressive episode in patients diagnosed with bipolar disorder, major depressive disorder, and a group of healthy control subjects. Depressed patients will be treated with a combination of fluoxetine and olanzapine and undergo MRI scans before, during, and after pharmacotherapy.
NCT00191399 ↗	Bipolar Depression Study: Bipolar Depression Assessment Study on Treatment Response	Completed	Eli Lilly and Company	Phase 4	2004-05-01	The primary objective of this study is to assess the efficacy of olanzapine and fluoxetine combined on all the visits as compared with the baseline visit in patients with bipolar disorder, measured by the total score of the Montgomery-Asberg Depression Rating Scale (MADRS).

Clinical Trial Conditions for fluoxetine hydrochloride; olanzapine

Condition Name

Condition Name for fluoxetine hydrochloride; olanzapine
Intervention	Trials
Bipolar Depression	4
Major Depressive Disorder	3
Treatment Resistant Depression	2
Bipolar Disorder	2

Condition MeSH

Condition MeSH for fluoxetine hydrochloride; olanzapine
Intervention	Trials
Depression	13
Depressive Disorder	12
Bipolar Disorder	7
Disease	4

Clinical Trial Locations for fluoxetine hydrochloride; olanzapine

Trials by Country

Trials by Country for fluoxetine hydrochloride; olanzapine
Location	Trials
United States	46
Canada	5
China	3
Puerto Rico	2
India	2

Trials by US State

Trials by US State for fluoxetine hydrochloride; olanzapine
Location	Trials
Pennsylvania	3
California	3
Massachusetts	3
Missouri	2
Florida	2

Clinical Trial Progress for fluoxetine hydrochloride; olanzapine

Clinical Trial Phase

Clinical Trial Phase for fluoxetine hydrochloride; olanzapine
Clinical Trial Phase	Trials
Phase 4	9
Phase 3	3
Phase 1/Phase 2	2

Clinical Trial Status

Clinical Trial Status for fluoxetine hydrochloride; olanzapine
Clinical Trial Phase	Trials
Completed	11
Recruiting	3
Terminated	1

Clinical Trial Sponsors for fluoxetine hydrochloride; olanzapine

Sponsor Name

Sponsor Name for fluoxetine hydrochloride; olanzapine
Sponsor	Trials
Eli Lilly and Company	7
National Alliance on Mental Illness Westside Los Angeles	1
University Health Network, Toronto	1

Sponsor Type

Sponsor Type for fluoxetine hydrochloride; olanzapine
Sponsor	Trials
Other	18
Industry	9
NIH	1