CLINICAL TRIALS PROFILE FOR EPINEPHRINE BITARTRATE
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All Clinical Trials for epinephrine bitartrate
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT02353676 ↗ | Bupivacaine Supplementation For Postoperative Pain Control In Surgical Removal Of Mandibular Third Molars | Unknown status | Cosmozone Dental Clinic | N/A | 2015-01-01 | Control of postoperative pain is a foremost goal in achieving a satisfactory postoperative recovery. Surgical removal of lower third molars is accompanied by postoperative pain that is at its peak in the first 12 hours. Our study evaluates if the use of 2% lidocaine hydrochloride for the surgical removal of lower third molars with a postoperative 0.5% bupivacaine supplementation would result in lesser postoperative pain and a decrease in ingestion of oral analgesics to control the pain when compared to a placebo. |
| NCT03672500 ↗ | Perineal Local Infiltration Study | Recruiting | Sunnybrook Health Sciences Centre | N/A | 2018-09-14 | The prevalence of birth canal lacerations is more than 70% of all deliveries in Canada. The repair of such lacerations is usually done using a pre-existing epidural analgesia. Once the analgesic effect of the epidural analgesia fades, the laceration may cause intolerable pain, and result in emotional stress, difficulties in ambulation and breastfeeding, and more. The research team hypothesis is that adding a locally injected analgesic, which will take effect once the epidural analgesia fades, may alleviate perineal pain, prevent such difficulties, and improve women's overall well-being and satisfaction. The proposed trial is a two-arm, single-masked, randomized trial. Women with a working epidural analgesia, and a laceration will be invited to participate. Women in the local anesthesia (LA) arm will get a LA injected to the laceration and women in the sham arm will get no injection. The differences in perineal pain between the groups will be evaluated at 6 hours after last epidural dose. |
| NCT05152901 ↗ | Study of Inhaled Epinephrine and Intramuscular Epinephrine Administered to Healthy Adults | Not yet recruiting | Novotech (Australia) Pty Limited | Phase 1 | 2022-01-23 | This is a study to determine the relative bioavailability of inhaled epinephrine compared with 0.3mg epinephrine administered IM in healthy male and female participants. |
| NCT05152901 ↗ | Study of Inhaled Epinephrine and Intramuscular Epinephrine Administered to Healthy Adults | Not yet recruiting | De Motu Cordis | Phase 1 | 2022-01-23 | This is a study to determine the relative bioavailability of inhaled epinephrine compared with 0.3mg epinephrine administered IM in healthy male and female participants. |
| NCT06977659 ↗ | Early Norepinephrine in Trauma Patients With Hemorrhagic Shock | ENROLLING_BY_INVITATION | Siriraj Hospital | PHASE1 | 2025-05-20 | The goal of this clinical trial is to learn if norepinephrine works to treat trauma patients with hemorrhagic shock. It will also learn about the safety of norepinephrine. The main questions it aims to answer are: Does norepinephrine affect the short-term mortality (24-hour mortality)? Does norepinephrine affect the long-term mortality (30-day mortality), survival with favorable outcome, total volume of blood product and crystalloid given in 24 hours, estimated blood loss within 24 hours, resuscitation-related complications, and length of ICU and hospital stay? What medical problems do participants have when receiving norepinephrine? Researchers will compare norepinephrine to a placebo (a look-alike substance that contains no drug) to see if norepinephrine works to treat trauma patients with hemorrhagic shock. Participants will: Receive norepinephrine or a placebo intravenously within 1 hour after randomization, infused for 24 hours after randomization, and then discontinued. Patients are monitored for outcomes and adverse events. |
| NCT06977659 ↗ | Early Norepinephrine in Trauma Patients With Hemorrhagic Shock | ENROLLING_BY_INVITATION | Visarat Palitnonkiat | PHASE1 | 2025-05-20 | The goal of this clinical trial is to learn if norepinephrine works to treat trauma patients with hemorrhagic shock. It will also learn about the safety of norepinephrine. The main questions it aims to answer are: Does norepinephrine affect the short-term mortality (24-hour mortality)? Does norepinephrine affect the long-term mortality (30-day mortality), survival with favorable outcome, total volume of blood product and crystalloid given in 24 hours, estimated blood loss within 24 hours, resuscitation-related complications, and length of ICU and hospital stay? What medical problems do participants have when receiving norepinephrine? Researchers will compare norepinephrine to a placebo (a look-alike substance that contains no drug) to see if norepinephrine works to treat trauma patients with hemorrhagic shock. Participants will: Receive norepinephrine or a placebo intravenously within 1 hour after randomization, infused for 24 hours after randomization, and then discontinued. Patients are monitored for outcomes and adverse events. |
| NCT07013071 ↗ | Hemodynamic Effects of Different Vasoconstrictors in Mandibular Exodontia | COMPLETED | King Abdulaziz University | PHASE4 | 2024-02-10 | Title of Study: The Effect of Different Vasoconstrictive Agents on Hemodynamics Among Patients Undergoing Simple Mandibular Exodontia: A Triple-Blind Randomized Controlled Trial Location: King Abdulaziz University Dental Hospital (KAUFD), Jeddah, Saudi Arabia What Is This Study About? This study examines two types of vasoconstrictive agents used alongside local anesthetic during simple lower tooth extractions: * Epinephrine (1:100,000) * Epinephrine Bitartrate (1:55,000) What are vasoconstrictors? Vasoconstrictors help control bleeding and extend the numbing effect during dental procedures. They are usually added to local anesthetics (numbing agent) during dental procedures. This research aims to answer the following questions: 1. Which one of the vasoconstrictive agents has less effect on the heart rate and blood pressure 2. Which one offers better pain control? Who Can participate? * Adult patient +18 year/old or above (healthy or with well-controlled conditions like hypertension) * Patients who require non-surgical lower tooth extractions * Procedures will be done by supervised fifth and sixth-year dental students Potential Risks and Discomforts Like any medical procedure, there are some potential risks, including: From the anesthesia and vasoconstrictors: * Allergic reaction * Prolonged numbness * Changes in blood pressure and heart rate From the tooth extraction itself: * Bleeding * Pain or discomfort * Swelling or bruising * Infection * Dry socket * Delayed healing * Damage to nearby teeth or tissues * Fracture of the tooth or jawbone * Numbness or altered sensation (temporary or permanent) * Sinus complications (in upper tooth extractions) * The need for additional procedures Potential Benefits * Free tooth extraction * Blood pressure monitoring - with referral to a primary care provider if undiagnosed high blood pressure is detected Costs There are no additional costs to participate in this research. Treatment and extraction are provided free of charge. Compensation / Treatment for Injury If a participant is injured as a result of being in this study: * Necessary treatment and medical care will be provided by the research team. * No financial compensation is available from King Abdulaziz University Dental Hospital (KAUFD). Confidentiality Participants' identity and medical information will be kept confidential. Only authorized researchers and relevant oversight bodies may access Participants' medical/dental records for monitoring or auditing purposes, in accordance with laws and regulations. Any published results will not identify the participants. |
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