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Last Updated: October 1, 2020

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CLINICAL TRIALS PROFILE FOR ENCORAFENIB

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All Clinical Trials for encorafenib

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01777776 Safety and Efficacy of LEE011 and LGX818 in Patients With BRAF Mutant Melanoma. Terminated Array BioPharma Phase 1/Phase 2 2013-07-01 To evaluate the safety, tolerability and efficacy of LEE011 and LGX818 when administered orally to patients with BRAF mutant melanoma.
NCT01820364 LGX818 in Combination With Agents (MEK162; BKM120; LEE011; BGJ398; INC280) in Advanced BRAF Melanoma Completed Array BioPharma Phase 2 2013-11-01 The primary purpose of the Phase II CLGX818X2102 study is to assess the anti-tumor activity of LGX818 in combination with selected agents.
NCT02109653 Efficacy and Safety of LGX818 in Patients With Advanced or Metastatic BRAF V600 Mutant NSCLC Withdrawn Array BioPharma Phase 2 2015-06-01 This is an open-label, multi-center, single arm phase II study to evaluate the efficacy and safety of novel BRAF (B-raf murine sarcoma viral oncogene homolog B1) inhibitor encorafenib (LGX818) when used as single agent in patients with advanced or metastatic (stage IIIB or IV) BRAF V600 mutant NSCLC. Patients must have progressed on or after at least one previous systemic, anti-cancer therapy for locally advanced or metastatic NSCLC.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for encorafenib

Condition Name

Condition Name for encorafenib
Intervention Trials
Metastatic Microsatellite Stable Colorectal Carcinoma 2
Stage IV Melanoma 2
Metastatic Melanoma 2
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Condition MeSH

Condition MeSH for encorafenib
Intervention Trials
Melanoma 11
Colorectal Neoplasms 4
Carcinoma 3
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Clinical Trial Locations for encorafenib

Trials by Country

Trials by Country for encorafenib
Location Trials
United States 39
Spain 8
Germany 3
Netherlands 3
Canada 3
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Trials by US State

Trials by US State for encorafenib
Location Trials
California 6
Maryland 4
Tennessee 3
New York 3
Colorado 3
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Clinical Trial Progress for encorafenib

Clinical Trial Phase

Clinical Trial Phase for encorafenib
Clinical Trial Phase Trials
Phase 3 1
Phase 2 17
Phase 1/Phase 2 5
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Clinical Trial Status

Clinical Trial Status for encorafenib
Clinical Trial Phase Trials
Not yet recruiting 15
Recruiting 6
Withdrawn 2
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Clinical Trial Sponsors for encorafenib

Sponsor Name

Sponsor Name for encorafenib
Sponsor Trials
Array BioPharma 13
National Cancer Institute (NCI) 8
Pierre Fabre Medicament 3
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Sponsor Type

Sponsor Type for encorafenib
Sponsor Trials
Industry 20
Other 20
NIH 8
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