Dacomitinib (PF-00299804) As A Single Oral Agent In Selected Patients With Adenocarcinoma Of The Lung
This study will explore the safety and efficacy of the oral PanHER inhibitor PF-00299804 in
patients with adenocarcinoma of the lung who are either non-smokers (<100 cigarette, cigar
or pipe lifetime) or former light smokers ( less than 10 pack-years and stopped at least 15
years) or have known EGFR activating mutation; or patients with HER 2 amplification or
ARCHER 1009 : A Study Of Dacomitinib (PF-00299804) Vs. Erlotinib In The Treatment Of Advanced Non-Small Cell Lung Cancer
This is a multinational, multicenter, randomized,double-blinded, Phase 3 study comparing the
efficacy and safety of treatment with PF-00299804 to treatment with erlotinib in patients
with advanced non-small cell lung cancer, previously treated with at least one prior
regimen. Analyses of primary objective (Progression Free Survival) will be done in two
co-primary populations as defined in the protocol.
Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO
To assess the impact of prophylactic treatment on the incidence of adverse events in
advanced NSCLC patients (post chemotherapy) treated with dacomitinib daily as a single
agent. To assess the impact of an interrupted dacomitinib dosing schedule in Cycle 1 on the
incidence of adverse events in first-line advanced NSCLC patients with an EGFR mutation
(HER-1 mutation, HER-2 mutation or HER-2 amplification).
Safety and Efficacy of PF-299804 (Dacomitinib), a Pan-HER Irreversible Inhibitor, in Patients With Recurrent Glioblastoma With EGFR Amplification or Presence of EGFRvIII Mutation. A Phase II CT.
Active, not recruiting
This multicenter, 2-stage, open-label, phase II trial aims to assess the efficacy and safety
of dacomitinib in adult patients with recurrent Glioblastoma (GBM) with EGFR gene
amplification and/or EGFRvIII mutation.
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