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Generated: September 19, 2018

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CLINICAL TRIALS PROFILE FOR CLONAZEPAM

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Clinical Trials for clonazepam

Trial ID Title Status Sponsor Phase Summary
NCT00025740 Clonazepam and Paroxetine for Rapid Treatment of Post-Traumatic Stress Disorder Completed National Institute of Mental Health (NIMH) Phase 4 Post-Traumatic Stress Disorder (PTSD) is an anxiety disorder that follows exposure to an extremely traumatic stressors. PTSD is associated with serious symptoms. While numerous approaches have been used to treat PTSD, these treatments have several limiting factors. This study will evaluate a combination of the drugs clonazepam and paroxetine for the treatment of PTSD symptoms. The main goal of treatment in patients with PTSD is to significantly reduce symptom severity and improve functioning. While numerous approaches have been used to treat PTSD, these treatments are limited by variable response rates, up to a 6-week lag period before clinical response, and sub-optimal side effect profile, including possible worsening of anxiety and insomnia prior to clinical response. The proposed study will examine whether combined treatment with a benzodiazepine (clonazepam) and a selective serotonin reuptake inhibitor (paroxetine) in patients with PTSD will accelerate the onset of clinical response. A second goal is to evaluate whether the rapid and clinically meaningful benefits are sustained until the end of the study, despite tapering off the benzodiazepine at the midpoint of the study. The safety and tolerability of a combination of paroxetine and clonazepam will be compared to paroxetine and placebo (an inactive pill) in the treatment of PTSD. Participants in this study will be randomly assigned to receive either paroxetine plus clonazepam or paroxetine plus a placebo for 12 weeks. Participants will have weekly clinic visits for the first 4 weeks of the study and every other week for the last 8 weeks. Symptoms of PTSD, anxiety, and depression will be evaluated and drug side effects will be noted during the follow-up visits.
NCT00031317 Evaluation of Clonazepam and Paroxetine for Panic Disorder With Depression Completed National Institute of Mental Health (NIMH) Phase 4 The purpose of this study is to examine the safety and effectiveness of the drug combination paroxetine and clonazepam in treating people with panic disorder (PD) and major depression. The main goal in treating people with PD is to rapidly reduce symptom severity and improve functioning. While numerous drug therapies have been used to treat PD, these treatments are limited by variable response rates and suboptimal side effect profiles. Evidence suggests that clonazepam given with a selective serotonin reuptake inhibitor (SSRI) can facilitate a rapid reduction in PD symptoms. However, it is unclear whether comorbid depression influences treatment response to the clonazepam and SSRI regimen. This study will examine whether combined treatment with clonazepam and the SSRI paroxetine will accelerate clinical response in participants with PD and comorbid depression. This study will also examine whether the benefits of treatment will be sustained until the end of the study despite tapering of clonazepam at the midpoint of the study. Participants in this study will be screened with medical and psychiatric interviews, a physical examination, electrocardiogram (ECG), and blood tests. Participants will then be randomly assigned to receive either paroxetine plus clonazepam or paroxetine plus placebo (an inactive pill) for 12 weeks. Participants will have weekly clinic visits during which symptoms and drug side effects will be checked and an interview to evaluate panic disorder and depression symptoms will be conducted.
NCT00118417 Therapies for Treatment-Resistant Panic Disorder Symptoms Completed National Institute of Mental Health (NIMH) Phase 2/Phase 3 This study will determine the effectiveness of different treatments for panic disorder symptoms in individuals who still have symptoms after initial treatment with medication.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for clonazepam

Condition Name

Condition Name for clonazepam
Intervention Trials
Schizophrenia 6
Epilepsy 4
Panic Disorder 3
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Condition MeSH

Condition MeSH for clonazepam
Intervention Trials
Disease 11
Mental Disorders 7
Schizophrenia 6
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Clinical Trial Locations for clonazepam

Trials by Country

Trials by Country for clonazepam
Location Trials
United States 23
Korea, Republic of 3
Spain 3
Switzerland 3
China 2
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Trials by US State

Trials by US State for clonazepam
Location Trials
New York 5
Massachusetts 3
Maryland 3
Ohio 2
California 2
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Clinical Trial Progress for clonazepam

Clinical Trial Phase

Clinical Trial Phase for clonazepam
Clinical Trial Phase Trials
Phase 4 16
Phase 3 5
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for clonazepam
Clinical Trial Phase Trials
Completed 25
Recruiting 5
Enrolling by invitation 3
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Clinical Trial Sponsors for clonazepam

Sponsor Name

Sponsor Name for clonazepam
Sponsor Trials
National Institute of Mental Health (NIMH) 5
New York State Psychiatric Institute 4
FundaciĆ³n Marques de Valdecilla 3
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Sponsor Type

Sponsor Type for clonazepam
Sponsor Trials
Other 63
Industry 10
NIH 8
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Serving hundreds of leading biopharmaceutical companies globally:

Chubb
Cantor Fitzgerald
Queensland Health
Baxter
Julphar
Healthtrust
Farmers Insurance
Fish and Richardson
Cipla

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