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Last Updated: March 28, 2024

CLINICAL TRIALS PROFILE FOR BRIMONIDINE TARTRATE; TIMOLOL MALEATE


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All Clinical Trials for brimonidine tartrate; timolol maleate

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00435058 ↗ Visual Function Changes After Intraocular Pressure Reduction Completed University of Sao Paulo N/A 2005-09-01 During the glaucomatous disease process, subpopulations of cells may be dead, damaged or healthy. Visual function changes could be observed due to a recovering of the suffering ganglion cells after the intraocular pressure reduction. This study aims at evaluating the correlation between intraocular pressure reduction and visual function changes in glaucoma patients after using antiglaucoma medications.
NCT00698945 ↗ Comparison of Istalol™ 0.5% QD (Timolol Maleate/Sorbitol Complex, ISTA Pharmaceutical) to Brimonidine Tartrate 0.1% BID as Adjunctive Therapy to Latanoprost 0.005% in Adults With Ocular Hypertension (OHT) or Open-Angle Glaucoma (OAG) Completed Bp Consulting, Inc Phase 4 2008-06-01 To assess the additional benefit of common adjunctive classes on the diurnal IOP curve in patients assessed as needing additional treatment to reach target intraocular pressure (IOP). To demonstrate superiority of IOP control with Istalol 0.5% QD compared to Brimonidine Tartrate 0.2% BID as adjunctive therapy in adults with uncontrolled IOP's (determined by P.I. based on target pressures) currently treated with Latanoprost 0.05% in the study eye(s).
NCT00811564 ↗ An Evaluation of the Fixed Combination Brimonidine Tartrate 0.2%/ Timolol Maleate 0.5% to Latanoprost 0.005% in Glaucoma or Ocular Hypertension Subjects Completed Allergan Phase 4 2008-12-01 A three-month evaluation comparing the safety and efficacy of a fixed combination of 0.2% brimonidine tartrate/0.5% timolol maleate with that of latanoprost 0.005%, a prostaglandin analogue in glaucoma or ocular hypertension subjects
NCT00811850 ↗ Comparing Effects of Two Fixed Combinations Ophthalmic Solutions on Ocular Blood Flow Completed Allergan Phase 4 2008-12-01 A 10 week evaluation, crossover design study including a 3 week washout period between treatments, to determine the effects of Combigan® (fixed combination brimonidine tartrate 0.2%/timolol maleate 0.5%) and Cosopt® (fixed combination dorzolamide hydrochloride-timolol maleate ophthalmic solutions) on ocular blood flow as measured by retrobulbar blood flow.
NCT01284166 ↗ Safety and Efficacy of Triple Combination Therapy With Dorzolamide Hydrochloride / Brimonidine Tartrate / Timolol Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension Withdrawn Allergan Phase 3 2013-07-01 This study will investigate the safety and efficacy of Triple Combination Therapy with dorzolamide hydrochloride/brimonidine tartrate/timolol ophthalmic solution in patients with glaucoma or ocular hypertension who have elevated IOP on dorzolamide hydrochloride/timolol maleate combination therapy.
NCT01987752 ↗ Safety and Efficacy of Combigan® Ophthalmic Solution in Korea Completed Allergan 2009-01-01 This study is a Post-Marketing Surveillance study in Korea to evaluate the safety and efficacy of Combigan® (brimonidine tartrate/timolol maleate) Ophthalmic Solution in patients with Open Angle Glaucoma or Ocular hypertension with insufficient response to local beta blockers treated as per standard of care in clinical practice.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for brimonidine tartrate; timolol maleate

Condition Name

Condition Name for brimonidine tartrate; timolol maleate
Intervention Trials
Glaucoma 4
Ocular Hypertension 4
Glaucoma, Open-Angle 1
Open-Angle Glaucoma 1
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Condition MeSH

Condition MeSH for brimonidine tartrate; timolol maleate
Intervention Trials
Glaucoma 5
Ocular Hypertension 4
Hypertension 3
Glaucoma, Open-Angle 2
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Clinical Trial Locations for brimonidine tartrate; timolol maleate

Trials by Country

Trials by Country for brimonidine tartrate; timolol maleate
Location Trials
United States 3
Korea, Republic of 1
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Trials by US State

Trials by US State for brimonidine tartrate; timolol maleate
Location Trials
Indiana 1
New York 1
California 1
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Clinical Trial Progress for brimonidine tartrate; timolol maleate

Clinical Trial Phase

Clinical Trial Phase for brimonidine tartrate; timolol maleate
Clinical Trial Phase Trials
Phase 4 3
Phase 3 1
N/A 1
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Clinical Trial Status

Clinical Trial Status for brimonidine tartrate; timolol maleate
Clinical Trial Phase Trials
Completed 5
Withdrawn 1
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Clinical Trial Sponsors for brimonidine tartrate; timolol maleate

Sponsor Name

Sponsor Name for brimonidine tartrate; timolol maleate
Sponsor Trials
Allergan 4
University of Sao Paulo 1
Bp Consulting, Inc 1
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Sponsor Type

Sponsor Type for brimonidine tartrate; timolol maleate
Sponsor Trials
Industry 4
Other 2
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