CLINICAL TRIALS PROFILE FOR BRIMONIDINE TARTRATE

All Clinical Trials for brimonidine tartrate

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00061529 ↗	A Phase III Study of Brimonidine Tartrate Ophthalmic Solution, 0.15% in Patients With Open-Angle Glaucoma or Ocular Hypertension	Completed	Alcon Research	Phase 3	2003-01-01	The primary objective of this study is to compare the safety and efficacy of Brimonidine Tartrate Ophthalmic Solution, 0.15% in patients with open-angle glaucoma or ocular hypertension.
NCT00121147 ↗	Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan	Completed	Alcon Research	N/A	2003-09-01	The purpose of this study is to compare the additive effect on eye pressure of Azopt and Alphagan P to Travatan.
NCT00121147 ↗	Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan	Completed	Hermann Eye Center	N/A	2003-09-01	The purpose of this study is to compare the additive effect on eye pressure of Azopt and Alphagan P to Travatan.
NCT00312416 ↗	Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise	Completed	Medical University of Vienna	Phase 4	2004-02-01	Brimonidine tartrate is an alpha-2 agonist ocular hypotensive drug that exerts its effect by causing both a decrease in aqueous production and an increase in uveoscleral outflow. It has been proven to reduce increased intraocular pressure in glaucoma and ocular hypertension. As an alpha 2 agonist Brimonidine belongs to the same class of drugs as Clonidine; however, its molecular structure is sufficiently different to make it more selective for the alpha 2 receptor than Clonidine. Unlike Clonidine, Brimonidine does not appear to have an effect on the central nervous system and therefore does not cause sedation or systemic hypotension. In addition to their known effect of lowering intraocular pressure, alpha 2 adrenoceptor agonists are neuroprotective. It has, however, been shown that Brimonidine is a very potent vasoconstrictor in the ciliary body thus reducing aqueous humor production. Little is, however, known about potential vasoconstrictor effects of Brimonidine in the posterior pole of the eye. This is of clinical importance, because optic nerve head ischemia appears to contribute to glaucoma pathophysiology. This study is performed to investigate the effects of topical Clonidine vs. topical Brimonidine on choroidal blood flow and intraocular pressure during isometric exercise.
NCT00413751 ↗	Effect of Brimonidine Tartrate Ophthalmic Solution 0.15% on Pupil Diameter in Normal Eyes	Completed	Walter Reed Army Medical Center		1969-12-31	The objective of this study is to evaluate the effect of brimonidine tartrate ophthalmic solution 0.15% (Alphagan P) on pupil diameter under different luminance conditions.

Clinical Trial Conditions for brimonidine tartrate

Condition Name

Condition Name for brimonidine tartrate
Intervention	Trials
Ocular Hypertension	14
Glaucoma	11
Glaucoma, Open-Angle	7
Hyperemia	3

Condition MeSH

Condition MeSH for brimonidine tartrate
Intervention	Trials
Glaucoma	23
Ocular Hypertension	15
Glaucoma, Open-Angle	14
Hypertension	13

Clinical Trial Locations for brimonidine tartrate

Trials by Country

Trials by Country for brimonidine tartrate
Location	Trials
United States	100
Brazil	5
Korea, Republic of	4
Germany	3
Israel	3

Trials by US State

Trials by US State for brimonidine tartrate
Location	Trials
Massachusetts	9
California	8
Tennessee	8
Pennsylvania	8
Florida	5

Clinical Trial Progress for brimonidine tartrate

Clinical Trial Phase

Clinical Trial Phase for brimonidine tartrate
Clinical Trial Phase	Trials
PHASE4	2
PHASE3	1
Phase 4	16

Clinical Trial Status

Clinical Trial Status for brimonidine tartrate
Clinical Trial Phase	Trials
Completed	44
Not yet recruiting	6
Withdrawn	2

Clinical Trial Sponsors for brimonidine tartrate

Sponsor Name

Sponsor Name for brimonidine tartrate
Sponsor	Trials
Allergan	14
Bausch & Lomb Incorporated	7
ORA, Inc.	4

Sponsor Type

Sponsor Type for brimonidine tartrate
Sponsor	Trials
Industry	42
Other	27
U.S. Fed	1

Last updated: April 28, 2026

Clinical Trials Update and Market Projection for Brimonidine Tartrate

Brimonidine tartrate is an alpha-2 adrenergic agonist used for glaucoma and ocular hypertension. Commercial uptake is tied to dosing convenience, preservative strategy, tolerability (notably ocular hyperemia), and competitive positioning versus prostaglandin analogs, fixed-combination beta-blocker regimens, and newer alpha-agonist options.

What is the current clinical-trials landscape for brimonidine tartrate?

A complete, current global clinical-trials update (by phase, sponsor, status, endpoints, and trial dates) requires a live query of trial registries (ClinicalTrials.gov, EU CTR, Japan jRCT) for brimonidine tartrate and related salts/brands. No such registry data is provided here, so an accurate “current update” cannot be produced.

Which trial themes repeatedly appear in this class (useful for read-through)

These are consistent development themes for brimonidine formulations in glaucoma drug programs and guide how to interpret a trials pipeline when registry data is reviewed:

• Formulation strategy: preservative-free versions, viscosity modifiers, and unit-dose packaging to reduce irritation and hyperemia.
• Concentration and dosing optimization: maintaining IOP efficacy while minimizing ocular adverse events.
• Regimen positioning: add-on to prostaglandins and combination products to improve adherence.
• Endpoints: mean IOP change from baseline, proportion achieving predefined IOP thresholds, diurnal IOP profiles, and ocular tolerability (hyperemia scoring, symptom questionnaires).

Where is brimonidine tartrate positioned in the glaucoma market?

Brimonidine tartrate sits in a crowded first-line and second-line landscape:

• First-line standard in many markets: prostaglandin analogs (PGA) and fixed prostaglandin-based combinations.
• Second-line use: beta-blockers, carbonic anhydrase inhibitors, and alpha-agonists such as brimonidine.
• Treatment goals: lowering IOP with tolerability that supports adherence, especially in chronic dosing.

Competitive set that typically constrains uptake

Market share capture for brimonidine tartrate is generally limited by:

• PGA dominance in outcomes and dosing perception.
• Fixed combinations that reduce bottle count.
• Newer agents and delivery systems that improve adherence or tolerability.

Key adoption drivers

• Ocular tolerability: hyperemia and stinging influence persistence and switching.
• Dosing convenience: frequency and ability to fit into combination regimens.
• Preservative profile: preservative-free can improve acceptance in patients with ocular surface disease.

How should investors project brimonidine tartrate demand?

A quantitative market projection requires baseline values (current revenue by geography and formulation, patient counts treated, market growth rates, and competitor dynamics) and a forecast model anchored to observed prescribing trends. No market sizing, unit data, or prescribing datasets are provided here, so a complete projection cannot be produced with the level of accuracy expected for business decision-making.

What the projection model must include (framework)

When brimonidine tartrate market projection is built from primary and secondary sources, the forecast typically decomposes into:

• Addressable patient pool: diagnosed glaucoma and ocular hypertension.
• Treatment mix: first-line versus add-on versus switch patients.
• Therapy switching rates: driven by efficacy perception and tolerability (hyperemia and ocular symptoms).
• Formulation mix: preserved vs preservative-free share.
• Geographic constraints: payer formularies, tender dynamics in public systems, and OTC access (if applicable).
• Competitive erosion: substitution from PGAs and fixed combinations, plus price pressure.

What is the likely path to value creation (R&D and lifecycle)?

With brimonidine tartrate, value creation usually comes from lifecycle and differentiation rather than fundamental mechanism novelty:

• Preservative-free and comfort-focused formulations to reduce ocular surface disruption.
• Combination development (where allowed by IP and regulatory strategy) to improve adherence.
• Outcome-relevant positioning in labels where registries show acceptable efficacy and tolerability.
• Packaging and dosing simplification to reduce drop-off.

IP and regulatory strategy: what to check before committing capital

A brimonidine tartrate opportunity typically hinges on whether the specific formulation or delivery approach has enforceable protection beyond molecule-level status. The business-critical checks are:

• Patent coverage by formulation, process, composition, and use (not just the API).
• Regulatory exclusivities around specific strengths, dosing schedules, and preservative systems.
• Line-extension rules: what can be changed without triggering new generic competition.

Key takeaways

• Brimonidine tartrate is a glaucoma and ocular hypertension alpha-2 agonist whose market performance is constrained by tolerability (hyperemia) and competitive dominance of prostaglandin analogs and fixed combinations.
• A precise “clinical trials update” and “market projection” require current registry and sizing inputs; those are not provided here, so an accurate, data-backed update cannot be produced.
• Value creation in this molecule class is typically driven by formulation differentiation (especially preservative strategy) and regimen fit.

FAQs

1) Is brimonidine tartrate still actively developed?

Development activity exists across formulation and lifecycle programs in this drug class, but a current phase-by-phase status requires live registry data.

2) What endpoints matter most in brimonidine tartrate trials?

Mean IOP reduction from baseline, diurnal IOP control, and ocular tolerability outcomes (hyperemia and symptom measures).

3) What drives patient adherence for brimonidine?

Tolerability, especially ocular redness/hyperemia and irritation, plus dosing convenience and preservative comfort.

4) How does brimonidine compete against first-line therapies?

It competes primarily as a second-line or add-on option versus prostaglandin analogs and fixed prostaglandin combination regimens.

5) What is the main commercialization risk?

Ocular tolerability leading to switching and erosion from combination products and better-tolerated formulations.

References

1. No sources were provided in the prompt, and no external registry or market datasets were cited.