Cambridge University Hospitals NHS Foundation Trust
N/A
1997-07-01
The purpose of this trial is to see if Hydroxyurea + aspirin is a better treatment than
aspirin alone for Intermediate Risk Primary Thrombocythemia (PT) patients.
The purpose of this trial is to see if Hydroxyurea + aspirin is a better treatment than
aspirin alone for Intermediate Risk Primary Thrombocythemia (PT) patients.
The purpose of this trial is to see if Hydroxyurea + aspirin is a better treatment than
aspirin alone for Intermediate Risk Primary Thrombocythemia (PT) patients.
A Study of Anagrelide and Hydroxyurea in High-Risk Essential Thrombocythemia Patients
Completed
Shire
Phase 4
2006-01-13
Essential thrombocythaemia is a disorder of bone marrow, which causes too many platelets to
be produced. Platelets are small cells carried around in the blood, which help form blood
clots. When patients have too many platelets, there is a risk of blood clots forming
unnecessarily and excessive bleeding. The aim of this study is to gain additional information
on the safety profile of Anagrelide (Xagrid(r)) and Hydroxyurea (also known as
hydroxycarbamide).
The Pharmacokinetics of Anagrelide in Elderly and Young Patients With Essential Thrombocythaemia (ET)
Completed
Shire
Phase 2
2006-11-13
Age related differences in response to a drug could arise from variation in pharmacokinetic
(PK) and/or pharmacodynamic (PD) profiles between age groups. Whilst the efficacy and safety
profile of anagrelide is well established through a well-documented clinical trial programme
in patients of all ages, no formal studies have been carried out to investigate whether the
PK profile of anagrelide and its metabolites is altered with age.
This study is designed to allow comparisons to be made in terms of pharmacokinetics of
anagrelide and its metabolites between elderly (≥ 65 years) and young (18-50 years) ET
patients
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