Adderall XR Compared With Concerta in Treating Young Cancer Patients With Memory, Attention, and Depression
Terminated
National Cancer Institute (NCI)
Phase 2
2003-08-01
RATIONALE: Stimulant drugs such as dextroamphetamine-amphetamine and methylphenidate may help
improve memory, attention, and thinking problems caused by central nervous system (CNS)
treatment for cancer, and may help decrease depression.
PURPOSE: This randomized phase II trial is studying dextroamphetamine-amphetamine to see how
well it works compared to methylphenidate in treating depression and problems with memory,
attention, and thinking in children who have undergone CNS treatment for cancer. This trial
will also study how often depression is seen and if these medications might help.
Adderall XR Compared With Concerta in Treating Young Cancer Patients With Memory, Attention, and Depression
Terminated
University of South Florida
Phase 2
2003-08-01
RATIONALE: Stimulant drugs such as dextroamphetamine-amphetamine and methylphenidate may help
improve memory, attention, and thinking problems caused by central nervous system (CNS)
treatment for cancer, and may help decrease depression.
PURPOSE: This randomized phase II trial is studying dextroamphetamine-amphetamine to see how
well it works compared to methylphenidate in treating depression and problems with memory,
attention, and thinking in children who have undergone CNS treatment for cancer. This trial
will also study how often depression is seen and if these medications might help.
This study will assess two options to help patients better manage the cognitive fog and
emotional distress that may be associated with having Long-COVID. Long-COVID is post-COVID
conditions or symptoms lasting more than four weeks after infection. Clinicians from the UPMC
Long-COVID Clinic leading this study are evaluating the utility of computer-based evaluation
of COVID-related cognitive fog and the helpfulness of two intervention strategies to treat
moderate cognitive impairment using a randomized trial. The two intervention strategies
include 1) a standardized dosing of amphetamine/dextroamphetamine medication that has been
used to improve cognitive fog; and 2) a digital behavioral tool with an embedded health coach
that is used on a mobile phone.
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