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Last Updated: May 15, 2024

CLINICAL TRIALS PROFILE FOR ADAGRASIB

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All Clinical Trials for adagrasib

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Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT03785249 ↗	Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1	Recruiting	Mirati Therapeutics Inc.	Phase 1/Phase 2	2019-01-15	This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
NCT04613596 ↗	Phase 2 Trial of MRTX849 Monotherapy and in Combination With Pembrolizumab for NSCLC With KRAS G12C Mutation KRYSTAL-7	Recruiting	Mirati Therapeutics Inc.	Phase 2	2020-12-02	This Phase 2 study evaluates the efficacy and safety of MRTX849 monotherapy and in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS and who are candidates for first-line treatment.
NCT04685135 ↗	Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation	Recruiting	Mirati Therapeutics Inc.	Phase 3	2021-01-29	This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.
NCT04975256 ↗	Adagrasib in Combination With BI 1701963 in Patients With Cancer (KRYSTAL 14)	Recruiting	Boehringer Ingelheim	Phase 1	2021-08-12	This study will evaluate safety, tolerability, drug levels, molecular effects and clinical activity of MRTX849 (adagrasib) in combination with BI 1701963 in patients with advanced solid tumors that have a KRAS G12C mutation.
NCT04975256 ↗	Adagrasib in Combination With BI 1701963 in Patients With Cancer (KRYSTAL 14)	Recruiting	Mirati Therapeutics Inc.	Phase 1	2021-08-12	This study will evaluate safety, tolerability, drug levels, molecular effects and clinical activity of MRTX849 (adagrasib) in combination with BI 1701963 in patients with advanced solid tumors that have a KRAS G12C mutation.
NCT05178888 ↗	Adagrasib in Combination With Palbociclib in Patients With Advanced Solid Tumors (KRYSTAL-16)	Recruiting	Mirati Therapeutics Inc.	Phase 1	2022-01-07	This study will evaluate the safety and clinical activity of MRTX849 (adagrasib) in combination with palbociclib in patients with advanced solid tumor malignancies with KRAS G12C mutation.
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Start Date	>Summary

Clinical Trial Conditions for adagrasib

Condition Name

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Condition Name for adagrasib
Intervention	Trials
Metastatic Cancer	6
Advanced Cancer	5
Malignant Neoplastic Disease	4
Malignant Neoplasm of Lung	3
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Condition MeSH

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Condition MeSH for adagrasib
Intervention	Trials
Lung Neoplasms	8
Neoplasms	7
Carcinoma, Non-Small-Cell Lung	6
Neoplasm Metastasis	5
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Clinical Trial Locations for adagrasib

Trials by Country

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Trials by Country for adagrasib
Location	Trials
United States	82
Italy	4
Spain	3
Netherlands	2
France	2
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Trials by US State

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Trials by US State for adagrasib
Location	Trials
Texas	9
New York	5
Colorado	4
California	4
Illinois	3
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Clinical Trial Progress for adagrasib

Clinical Trial Phase

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Clinical Trial Phase for adagrasib
Clinical Trial Phase	Trials
Phase 3	1
Phase 2	5
Phase 1/Phase 2	4
[disabled in preview]	6
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Clinical Trial Status

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Clinical Trial Status for adagrasib
Clinical Trial Phase	Trials
Not yet recruiting	9
Recruiting	7
[disabled in preview]	0
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Clinical Trial Sponsors for adagrasib

Sponsor Name

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Sponsor Name for adagrasib
Sponsor	Trials
Mirati Therapeutics Inc.	15
M.D. Anderson Cancer Center	3
Aadi Bioscience, Inc.	1
[disabled in preview]	3
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Sponsor Type

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Sponsor Type for adagrasib
Sponsor	Trials
Industry	20
Other	6
[disabled in preview]	0
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