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Serving leading biopharmaceutical companies globally:

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Generated: November 20, 2017

DrugPatentWatch Database Preview

CLINICAL TRIALS PROFILE FOR
ACETAMINOPHEN; CODEINE PHOSPHATE

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Clinical Trial Listing

Trial ID Title Status Sponsor Phase Summary
NCT00000138 Herpetic Eye Disease Study (HEDS) IUnknown statusNational Eye Institute (NEI)Phase 3 To evaluate the efficacy of topical corticosteroids in treating herpes simplex stromal keratitis in conjunction with topical trifluridine. To evaluate the efficacy of oral acyclovir in treating herpes simplex stromal keratitis in patients receiving concomitant topical corticosteroids and trifluridine. To evaluate the efficacy of oral acyclovir in treating herpes simplex iridocyclitis in conjunction with treatment with topical corticosteroids and trifluridine.
NCT00000425 Toward Better Outcomes in OsteoarthritisCompletedNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Phase 3 This study will determine if there is a difference between commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (a pain-reliever that does not prevent inflammation) for treating knee pain in osteoarthritis (OA). The two main results we will look at are disease progression according to x-rays and disability over 3.5 years. Study participants with moderate knee OA and knee pain will continue taking their NSAID or stop taking their NSAID and start taking acetaminophen. Every 6 months we will send the participants questionnaires that ask about pain, medication use, and disability. We will take x-rays of the knees at the start of the study and again at the end of the study.
NCT00000425 Toward Better Outcomes in OsteoarthritisCompletedStanford UniversityPhase 3 This study will determine if there is a difference between commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (a pain-reliever that does not prevent inflammation) for treating knee pain in osteoarthritis (OA). The two main results we will look at are disease progression according to x-rays and disability over 3.5 years. Study participants with moderate knee OA and knee pain will continue taking their NSAID or stop taking their NSAID and start taking acetaminophen. Every 6 months we will send the participants questionnaires that ask about pain, medication use, and disability. We will take x-rays of the knees at the start of the study and again at the end of the study.
NCT00000491 Aspirin-Myocardial Infarction Study (AMIS)CompletedNational Heart, Lung, and Blood Institute (NHLBI)Phase 3 To determine whether the daily administration of 1 gm of aspirin to individuals with a documented myocardial infarction would result in a significant reduction in mortality over a three year period.
NCT00000713 A Phase I Clinical Trial To Evaluate the Toxicity, Antiviral and Immunomodulatory Effects of a Range of Doses of Ampligen in HIV-Infected SubjectsCompletedNational Institute of Allergy and Infectious Diseases (NIAID)Phase 1 To determine the safety of ampligen at several doses in HIV-infected patients who have not yet developed AIDS or advanced AIDS related complex (ARC). Biologic, antiviral, and immunologic effects will be studied. Evidence indicates that a long period with no symptoms follows infection with HIV. Individuals who are infected with the virus could benefit from therapy with a drug that acts to kill the virus or to stimulate the immune system of the individual or both. The immune system is the means the human body has for fighting infections. Ampligen is a suitable drug for clinical trials against HIV because it has been shown to stimulate the immune system and to inhibit HIV in vitro (test tube) at drug levels that can be achieved without noticeable clinical side effects.
NCT00000731 Evaluation of the Interaction Between Acetaminophen and ZidovudineCompletedNational Institute of Allergy and Infectious Diseases (NIAID)N/A To determine if zidovudine (AZT) and acetaminophen (APAP) interact when given to the same patient, and if so, the manner of interaction. Patients with AIDS often require therapy with painkillers for the management of mild pain and discomfort associated with their disease, and APAP is often prescribed. AZT is being used to treat AIDS patients. It is important for doctors to understand how AZT and APAP may interact when given to the same patient, because other studies have suggested that the dosage of AZT may have to be adjusted when given with APAP in order to avoid or minimize adverse effects.
NCT00000735 A Clinical Trial To Evaluate the Toxicity and Antiviral Effects of a Range of Doses of Ampligen in p24 Antigen Positive HIV-Infected Patients With AIDS or ARCCompletedNational Institute of Allergy and Infectious Diseases (NIAID)Phase 1 To determine the safety of intravenous infusion of ampligen in symptomatic HIV-infected patients at several dose levels, to determine the maximum dose that can be tolerated, and to measure the effects of ampligen on the HIV virus infection, immune function, and clinical condition. Ampligen is a suitable drug for clinical trials against HIV because it has been shown to stimulate the immune system and to inhibit replication of HIV in vitro at doses that can be achieved without noticeable harmful side effects.
NCT00001716 Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell AnemiaCompletedNational Institutes of Health Clinical Center (CC)Phase 2 Sickle cell anemia is the most common genetic disease affecting African-Americans. About 1 in every 1000 African-Americans has the disease and 1 in every 12 carry the genes that could be passed on to their children. People with sickle cell anemia have abnormal hemoglobin, the molecules responsible for carrying oxygen in the blood. The abnormal hemoglobin can cause damage to the red blood cells. The damaged red blood cell may then stick in the blood vessels and cause pain and injury to organs. Some of the complications caused by the sticking of blood cells are called acute pain crisis and acute chest syndrome (ACS). Nitric oxide (NO) is a gas that has been proposed as a possible therapy for the ACS complication of sickle cell anemia. Studies have shown that NO may favorably affect sickle cell hemoglobin molecules, thereby improving blood flow through small vessels. This study is designed to evaluate the effects of NO, when taken in combination with a drug called nitroglycerin on patients with sickle cell anemia and normal volunteers. The effects of these two drugs only last while the patient is receiving them. Researchers hope the information learned from this study will help to develop new therapies for sickle cell anemia.
NCT00002146 Safety and Efficacy of Intravenous Magnesium Sulfate in Modulating Changes in Symptoms and Divalent Cation Levels Associated With Foscavir Therapy: A Phase IV Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Pilot StudyCompletedAstra USAPhase 4 To determine whether acute ionized hypomagnesemia and hypocalcemia immediately following foscarnet infusions can be lessened or eliminated by prior infusion of magnesium sulfate. To determine whether reductions in ionized magnesium, ionized calcium, and parathyroid hormone levels following foscarnet infusions are lessened by preinfusion of magnesium sulfate. To evaluate the safety of intravenous magnesium sulfate prior to foscarnet infusion by monitoring blood pressure, heart rate, and heart rhythm. To characterize the effect of magnesium sulfate on foscarnet blood levels and urinary excretion of calcium, magnesium, phosphate, and foscarnet.
NCT00002721 Doxorubicin Plus Estramustine in Treating Patients With Metastatic Prostate CancerCompletedUniversity of New MexicoPhase 1 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of doxorubicin plus estramustine in treating patients with metastatic recurrent prostate cancer that does not respond to hormone therapy.
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Conditions

Condition Name

Condition Name for acetaminophen; codeine phosphate
Intervention Trials
Pain 119
Leukemia 67
Lymphoma 58
Pain, Postoperative 38
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Condition MeSH

Condition MeSH for acetaminophen; codeine phosphate
Intervention Trials
Leukemia 169
Pain, Postoperative 110
Lymphoma 110
Leukemia, Lymphoid 99
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Trial Locations

Trials by Country

Trials by Country for acetaminophen; codeine phosphate
Location Trials
Japan 83
Germany 77
Italy 67
Australia 63
China 61
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Trials by US State

Trials by US State for acetaminophen; codeine phosphate
Location Trials
Texas 211
California 181
New York 178
Pennsylvania 121
Washington 116
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Clinical Trial Progress

Clinical Trial Phase

Clinical Trial Phase for acetaminophen; codeine phosphate
Clinical Trial Phase Trials
Phase 4 358
Phase 3 272
Phase 2/Phase 3 35
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Clinical Trial Status

Clinical Trial Status for acetaminophen; codeine phosphate
Clinical Trial Phase Trials
Completed 764
Recruiting 259
Not yet recruiting 131
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Clinical Trial Sponsors

Sponsor Name

Sponsor Name for acetaminophen; codeine phosphate
Sponsor Trials
National Cancer Institute (NCI) 174
Fred Hutchinson Cancer Research Center 65
M.D. Anderson Cancer Center 49
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Sponsor Type

Sponsor Type for acetaminophen; codeine phosphate
Sponsor Trials
Other 1411
Industry 625
NIH 298
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Serving leading biopharmaceutical companies globally:

Medtronic
Teva
Fuji
Daiichi Sankyo
Express Scripts
US Department of Justice
Farmers Insurance
Dow
Cantor Fitzgerald
UBS

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