Last Updated: June 26, 2026

CLINICAL TRIALS PROFILE FOR ACECLIDINE HYDROCHLORIDE


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All Clinical Trials for aceclidine hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02554396 ↗ Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Completed Presbyopia Therapies, LLC Phase 2 2015-09-01 This is a one-day, randomized, double-masked, single-center evaluation of the efficacy and safety of PRX-100 ophthalmic solution compared to placebo in 20 subjects (randomized 4:1, PRX-100:placebo) to evaluate the safety of PRX-100 and the magnitude and duration of effects on improving near-vision acuity.
NCT03201562 ↗ A Single-Center, Double-Masked Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Completed Presbyopia Therapies, LLC Phase 2 2017-04-30 To evaluate the safety and efficacy of PRX-100 compared with aceclidine alone and vehicle in the treatment of early to moderate presbyopia.
NCT05294328 ↗ Evaluation of the Efficacy and Safety of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia Recruiting ORA, Inc. Phase 2 2022-04-01 To evaluate the safety and efficacy of Aceclidine/Brimonidine (LNZ101) compared with Aceclidine (LNZ100) and vehicle in the treatment of Presbyopia.
NCT05294328 ↗ Evaluation of the Efficacy and Safety of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia Recruiting LENZ Therapeutics, Inc Phase 2 2022-04-01 To evaluate the safety and efficacy of Aceclidine/Brimonidine (LNZ101) compared with Aceclidine (LNZ100) and vehicle in the treatment of Presbyopia.
NCT05431543 ↗ Evaluation of the Safety and Effectiveness of Aceclidine (LNZ101) and Aceclidine + Brimonidine (LNZ100) in the Treatment of Presbyopia Recruiting ORA, Inc. Phase 2 2022-07-01 To evaluate the safety and effectiveness of Aceclidine/Brimonidine (LNZ101) compared with Aceclidine (LNZ100) and vehicle in the treatment of Presbyopia.
NCT05431543 ↗ Evaluation of the Safety and Effectiveness of Aceclidine (LNZ101) and Aceclidine + Brimonidine (LNZ100) in the Treatment of Presbyopia Recruiting Alisyn Facemire Phase 2 2022-07-01 To evaluate the safety and effectiveness of Aceclidine/Brimonidine (LNZ101) compared with Aceclidine (LNZ100) and vehicle in the treatment of Presbyopia.
NCT05656027 ↗ Phase 3 Evaluation of the Safety and Efficacy of LNZ101 for the Treatment of Presbyopia Recruiting ORA, Inc. Phase 3 2022-12-19 Phase 3 study to evaluate the safety and effectiveness of LNZ101 for the treatment of Presbyopia.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for aceclidine hydrochloride

Condition Name

Condition Name for aceclidine hydrochloride
Intervention Trials
Presbyopia 7
Eye Diseases 5
Miosis 3
Near Vision 3
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Condition MeSH

Condition MeSH for aceclidine hydrochloride
Intervention Trials
Presbyopia 7
Eye Diseases 5
Refractive Errors 4
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Clinical Trial Locations for aceclidine hydrochloride

Trials by Country

Trials by Country for aceclidine hydrochloride
Location Trials
United States 10
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Trials by US State

Trials by US State for aceclidine hydrochloride
Location Trials
Massachusetts 4
California 3
Tennessee 2
Indiana 1
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Clinical Trial Progress for aceclidine hydrochloride

Clinical Trial Phase

Clinical Trial Phase for aceclidine hydrochloride
Clinical Trial Phase Trials
Phase 3 2
Phase 2 4
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for aceclidine hydrochloride
Clinical Trial Phase Trials
Recruiting 3
Completed 3
Not yet recruiting 1
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Clinical Trial Sponsors for aceclidine hydrochloride

Sponsor Name

Sponsor Name for aceclidine hydrochloride
Sponsor Trials
ORA, Inc. 5
LENZ Therapeutics, Inc 4
Presbyopia Therapies, LLC 2
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Sponsor Type

Sponsor Type for aceclidine hydrochloride
Sponsor Trials
Other 7
Industry 5
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