Cyclosporine A in Combination With Abacavir Sulfate, Lamivudine, and Zidovudine and Lopinavir/Ritonavir in HIV
National Institute of Allergy and Infectious Diseases (NIAID)
Cyclosporine A (CsA) is a common long-term treatment used to inhibit the immune response in
transplant patients who receive donor organs. CsA may also help people with HIV. The purpose
of this study is to determine the safety of and immune response to CsA when given with
abacavir sulfate (ABC), lamivudine (3TC), and zidovudine (AZT), (ABC/3TC/AZT) and
lopinavir/ritonavir (LPV/r) to HIV infected adults in the early stages of infection.
Study hypothesis: The combination of CsA and LPV/r given to acutely infected individuals will
result in lower levels of proviral DNA and latent infectious virus at 48 weeks compared to
acute infected individuals treated with LPV/r alone.
A Comparison of Two Anti-HIV Drug Regimens for Youth Who Have Failed Prior Therapy
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV infected children and adolescents who have taken many anti-HIV drugs may have limited
treatment options and are at high risk for progressing to AIDS. The purpose of this study is
to determine whether an anti-HIV treatment regimen of 2 protease inhibitors (PIs) and 2
nucleoside reverse transcriptase inhibitors (NRTIs) is more effective than a regimen of 4
NRTIs in treatment-experienced children and adolescents who have failed previous anti-HIV
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