Celecoxib in Patients With Newly Diagnosed GBM Who Are Receiving Anticonvulsant Drugs and Undergoing RT
Terminated
National Cancer Institute (NCI)
Phase 2
2003-10-01
RATIONALE: Celecoxib may stop the growth of tumor cells by blocking the enzymes necessary for
their growth. It is not yet known whether the effectiveness of celecoxib in treating
glioblastoma multiforme is decreased in patients who are receiving anticonvulsant drugs and
undergoing radiation therapy.
PURPOSE: Phase II trial to study the effectiveness of celecoxib in treating patients who are
receiving anticonvulsant drugs and undergoing radiation therapy for newly diagnosed
glioblastoma multiforme.
Celecoxib in Patients With Newly Diagnosed GBM Who Are Receiving Anticonvulsant Drugs and Undergoing RT
Terminated
Sidney Kimmel Comprehensive Cancer Center
Phase 2
2003-10-01
RATIONALE: Celecoxib may stop the growth of tumor cells by blocking the enzymes necessary for
their growth. It is not yet known whether the effectiveness of celecoxib in treating
glioblastoma multiforme is decreased in patients who are receiving anticonvulsant drugs and
undergoing radiation therapy.
PURPOSE: Phase II trial to study the effectiveness of celecoxib in treating patients who are
receiving anticonvulsant drugs and undergoing radiation therapy for newly diagnosed
glioblastoma multiforme.
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Last updated: July 27, 2026
Zonisamide clinical trials update, market analysis and revenue projection (2025-2035)
Zonisamide (INN; brand in the US: Zonegran, by ANI Pharmaceuticals historically; now under Hikma/Jazz legacy structures by market handling) has limited late-stage pipeline activity compared with newer antiseizure drugs. Near-term demand is supported by continued use in focal-onset seizures and treatment-resistant epilepsy, with growth constrained by generic penetration and class competition. Any meaningful uptake upside depends on (1) new label expansions, (2) differentiated delivery or combination assets, or (3) post-approval safety or utilization programs rather than new molecular entities.
No sufficient, specific, citable dataset is available in the provided input to produce a complete, accurate clinical trials update (NCT-level), market sizing baseline (current revenue by geography and formulation), or forward revenue projections with defensible assumptions tied to trial endpoints, regulatory milestones, or payer coverage dynamics.
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