CLINICAL TRIALS PROFILE FOR ZILEUTON

All Clinical Trials for ZILEUTON

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00056004 ↗	Zileuton in Preventing Lung Cancer in Patients With Bronchial Dysplasia	Completed	National Cancer Institute (NCI)	Phase 2	2003-06-01	RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of zileuton may be an effective way to prevent lung cancer in patients who have bronchial dysplasia. PURPOSE: Randomized phase II trial to study the effectiveness of zileuton in preventing lung cancer in patients who have bronchial dysplasia.
NCT00056004 ↗	Zileuton in Preventing Lung Cancer in Patients With Bronchial Dysplasia	Completed	Barbara Ann Karmanos Cancer Institute	Phase 2	2003-06-01	RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of zileuton may be an effective way to prevent lung cancer in patients who have bronchial dysplasia. PURPOSE: Randomized phase II trial to study the effectiveness of zileuton in preventing lung cancer in patients who have bronchial dysplasia.
NCT00070486 ↗	Carboplatin and Gemcitabine Combined With Celecoxib and/or Zileuton in Treating Patients With Advanced Non-Small Cell Lung Cancer	Completed	National Cancer Institute (NCI)	Phase 2	2003-12-01	RATIONALE: Drugs used in chemotherapy, such as carboplatin and gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Celecoxib and zileuton may stop the growth of tumor cells by stopping blood flow to the tumor and may block the enzymes necessary for tumor cell growth. Combining chemotherapy with celecoxib and/or zileuton may kill more tumor cells. PURPOSE: Randomized phase II trial to study the effectiveness of combining celecoxib and/or zileuton with carboplatin and gemcitabine in treating patients who have advanced non-small cell lung cancer.
NCT00070486 ↗	Carboplatin and Gemcitabine Combined With Celecoxib and/or Zileuton in Treating Patients With Advanced Non-Small Cell Lung Cancer	Completed	Alliance for Clinical Trials in Oncology	Phase 2	2003-12-01	RATIONALE: Drugs used in chemotherapy, such as carboplatin and gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Celecoxib and zileuton may stop the growth of tumor cells by stopping blood flow to the tumor and may block the enzymes necessary for tumor cell growth. Combining chemotherapy with celecoxib and/or zileuton may kill more tumor cells. PURPOSE: Randomized phase II trial to study the effectiveness of combining celecoxib and/or zileuton with carboplatin and gemcitabine in treating patients who have advanced non-small cell lung cancer.

Clinical Trial Conditions for ZILEUTON

Condition Name

Condition Name for ZILEUTON
Intervention	Trials
Asthma	6
Chronic Myelogenous Leukemia	2
Tobacco Use Disorder	2
Lung Cancer	2

Condition MeSH

Condition MeSH for ZILEUTON
Intervention	Trials
Asthma	6
Pulmonary Disease, Chronic Obstructive	2
Fibrosis	2
Leukemia, Myeloid	2

Clinical Trial Locations for ZILEUTON

Trials by Country

Trials by Country for ZILEUTON
Location	Trials
United States	75
India	1
Brazil	1

Trials by US State

Trials by US State for ZILEUTON
Location	Trials
Massachusetts	9
California	6
Michigan	5
Texas	4
Pennsylvania	4

Clinical Trial Progress for ZILEUTON

Clinical Trial Phase

Clinical Trial Phase for ZILEUTON
Clinical Trial Phase	Trials
Phase 4	5
Phase 3	2
Phase 2	7

Clinical Trial Status

Clinical Trial Status for ZILEUTON
Clinical Trial Phase	Trials
Completed	14
Terminated	5
Recruiting	1

Clinical Trial Sponsors for ZILEUTON

Sponsor Name

Sponsor Name for ZILEUTON
Sponsor	Trials
Critical Therapeutics	4
National Cancer Institute (NCI)	4
University of Massachusetts, Worcester	2

Sponsor Type

Sponsor Type for ZILEUTON
Sponsor	Trials
Other	15
Industry	8
NIH	7